Results 31 to 40 of about 299,501 (197)

Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges

open access: yesCells, 2019
Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated to GTP.
Néstor Prieto‐Domínguez   +2 more
semanticscholar   +1 more source

Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. [PDF]

open access: yes, 2015
Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Al-Bassam, Jawdat   +7 more
core   +2 more sources

GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis

open access: yesJournal of Cell Biology, 2016
Rab GTPases control vesicle formation and transport, but which proteins are important for their regulation is incompletely understood. Thomas and Fromme provide definitive evidence that TRAPPII is a GEF for the yeast Rab11 homologues Ypt31/32 and ...
Laura L Thomas, J. Christopher Fromme
semanticscholar   +1 more source

Emerging functions of mammalian mitochondrial fusion and fission [PDF]

open access: yes, 2005
Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is ...
Chan, David C., Chen, Hsiuchen
core   +1 more source

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting [PDF]

open access: yes, 2010
Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both ...
Shan, Shu-ou, Shen, Kuang
core   +3 more sources

Structural basis for the assembly of the Ragulator-Rag GTPase complex

open access: yesNature Communications, 2017
The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in regulating cell growth and metabolism by responding to cellular nutrient conditions.
R. Yonehara   +12 more
semanticscholar   +1 more source

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2004
The signaling pathways mediated by Rho family GTPases have been implicated in many aspects of cell biology. The specificity of the pathways is achieved in part by the selective interaction between Dbl family guanine nucleotide exchange factors (GEFs) and
Yuan Gao   +4 more
semanticscholar   +1 more source

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [PDF]

open access: yes, 2010
The dynamin-related GTPase OPA1 is mutated in autosomal dominant optic atrophy (DOA) (Kjer type), an inherited neuropathy of the retinal ganglion cells.
Alexander   +28 more
core   +3 more sources

Regulation of Mitochondrial Dynamics and Neurodegenerative Diseases [PDF]

open access: yes, 2011
Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent
Fujimura, Atsushi   +6 more
core   +1 more source

The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns

open access: yesF1000Research, 2016
Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology.
R. Fritz, O. Pertz
semanticscholar   +1 more source

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