Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins
Advanced Science, EarlyView.Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang +3 more
wiley +1 more source
Organic thermally activated delayed fluorescence material with strained benzoguanidine donor
Beilstein Journal of Organic Chemistry, 2023 Organic thermally activated delayed fluorescence (TADF) materials have been widely investigated due to their impressive electronic properties and applied potential for the third generation of organic light-emitting diodes (OLED).
Alexander C. Brannan +5 more
doaj +1 more source
Leishmaniasis: new approaches to disease control. [PDF]
, 2003 The leishmaniases afflict the world's poorest populations. Among the two million new cases each year in the 88 countries where the disease is endemic (fig 1), it is estimated that 80% earn less than $2 a day.
Croft, Simon L +3 more
core +2 more sources
Novel Guanidine Compound against Multidrug-Resistant Cystic Fibrosis-Associated Bacterial Species
Molecules, 2018 Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis (CF). Infections dominated by non-fermentative Gram-negative bacilli are particularly difficult to treat and highlight an urgent need for the development of new class of agents ...
A. Saeed +5 more
semanticscholar +1 more source
Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders
Advanced Science, EarlyView.Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li +7 more
wiley +1 more source
To Be or Not To Be a Molecular Ion: The Role of the Solvent in Photoionization of Arginine. [PDF]
, 2019 Application of photoionization mass spectroscopy, a technique capable of assessing protonation states in complex molecules in the gas phase, is challenging for arginine due to its fragility. We report photoionization efficiencies in the valence region of
Ahmed, Musahid +7 more
core +2 more sources
Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization
Advanced Science, EarlyView.In this work, we developed a post‐functionalization approach to achieve water‐soluble cyclic polyphthalaldehyde (cPPA) polymers via click chemistry. ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to
Liting He +5 more
wiley +1 more source
Exploring 3D-QSAR to identify potential small molecule for treating Alzheimer disease: A case study with b-secretase inhibitors [PDF]
Scripta MedicaBackground/Aim: One of the most common neurological conditions that results in dementia is Alzheimer disease. The current treatment options for Alzheimer disease include acetylcholinesterase (AChE) and -methyl-D-aspartate (NMDA) inhibitors, but there is ...
More Uttam A. +9 more
doaj +1 more source
Growth inhibition of neurospora by canavanine, and its reversal [PDF]
, 1948 Canavanine, an amino acid from jack beans, was discovered by Kitagawa and coworkers in 1929 (1, 2). The substance is not combined in the proteins of the seed, but occurs in the free state, and makes up 2.5 per cent of the dry weight of jack beans (3). In
Horowitz, N. H., Srb, Adrian M.
core
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition [PDF]
, 2017 Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD).
Bu, Guojun +8 more
core +2 more sources