Results 21 to 30 of about 133,980 (384)

Discovery and characterization of a fourth class of guanidine riboswitches

Nucleic Acids Research, 2020
Riboswitches are RNAs that specifically sense a small molecule and regulate genes accordingly. The recent discovery of guanidine-binding riboswitches revealed the biological significance of this compound, and uncovered genes related to its biology.
Felina Lenkeit, I. Eckert, J. Hartig, Z. Weinberg   +3 more
semanticscholar   +1 more source

The Core Histone-binding Region of the Murine Cytomegalovirus 89K Immediate Early Protein [PDF]

, 1991
The gene regulatory immediate early protein, pp89, of murine cytomegalovirus interacts with both DNA-associated and isolated histones in vitro. We characterized the histone-binding region of pp89 and its cellular localization during cell division to ...
Bühler, Bernhard, Koszinowski, Ulrich H., Messerle, Martin, Münch, Konrad   +3 more
core   +1 more source

Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria

bioRxiv, 2020
An intriguing consequence of ongoing riboswitch discovery efforts is the occasional identification of metabolic or toxicity response pathways for unusual ligands.
Hubert Salvail, Aparaajita Balaji, Diane Yu, Adam Roth, R. Breaker   +4 more
semanticscholar   +1 more source

Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant - Implications for disease susceptibility to Creutzfeldt-Jakob disease [PDF]

, 2004
The human PrP gene (PRNP) has two common alleles that encode either methionine or valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of human transmissible spongiform encyphalopathies, but the molecular mechanism by ...
Abdessamad Tahiri-Alaoui, Andrew C. Gill, Petra Disterer, William James, Prusiner, Weissmann, Will, Bruce, Hill, Prusiner, Prusiner, Collinge, Windl, Palmer, Brown, Baker, Cervenakova, Parchi, Hill, Collinge, Hauw, Goldfarb, Goldfarb, Dlouhy, Dermaut, Croes, Liemann, Riek, Alonso, Baskakov, Jackson, Baskakov, Gill, Lu, Lu, Landon, Safar, Bessen, Zahn, Riek, Nguyen, Tahiri-Alaoui, Santini, Wong, Wildegger, Matouschek, Vendruscolo, Kim, Fasman, Baskakov, Qin, Oesch, Conway, Sayer, Rhie, Schatzl, Mead   +56 more
core   +1 more source

Research Progress of Common Organic Guanidine Antibacterial Agents

To Chemistry Journal, 2020
Aim: The aim of this study is to investigate the antimicrobial properties of organic guanidine because of their strong alkalinity, high stability, low toxicity and good biological activity.
Hua Li, Yingping Qi, Yongfeng Shen, Hua Li   +3 more
doaj   +2 more sources

Dependence of Antimicrobial Effects of Guanidine-containing Pectin Derivatives from Some Structural Characteristics

Разработка и регистрация лекарственных средств, 2022
Introduction. Up to the present time, there are practically no studies on the relationship between the structural characteristics and biological activity of antimicrobial polymers synthesized by the chemical addition of guanidine groups to polysaccharide
O. R. Akhmedov, S. A. Shomurotov, A. S. Turaev, A. V. Sidarenka   +3 more
doaj   +1 more source

Soluplus solutions as thermothickening materials for topical drug delivery. [PDF]

, 2019
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed.
Abou Shamat, Mohamad, Cook, Michael
core   +2 more sources

Solving the conundrum: Widespread proteins annotated for urea metabolism in bacteria are carboxyguanidine deiminases mediating nitrogen assimilation from guanidine.

Biochemistry, 2020
Free guanidine is increasingly recognized as a relevant molecule in biological systems. Recently, it was reported that urea carboxylase acts preferentially on guanidine and, consequently, it was considered to participate directly in guanidine ...
Nicholas Schneider, Lambros J. Tassoulas, D. Zeng, Amanda J Laseke, N. J. Reiter, L. Wackett, M. Maurice   +6 more
semanticscholar   +1 more source

Allosteric Activation of the Par-6 PDZ Via a Partial Unfolding Transition [PDF]

, 2013
Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control.
Kovrigin, Evgeni L., Peterson, Francis C., Volkman, Brian F., Whitney, Dustin S.   +3 more
core   +2 more sources

Robust Guanidine Metal Catalysts for the Ring-Opening Polymerization of Lactide under Industrially Relevant Conditions.

ChemPlusChem, 2020
The increasing awareness of sustainability has led to enormous growth of the demand for bio-based and biodegradable polymers such as poly(lactide) (PLA). In industry, polymerization of lactide is currently carried out using tin catalysts (e.
P. Schäfer, S. Herres‐Pawlis
semanticscholar   +1 more source