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Mechanochemical synthesis of thioureas, ureas and guanidines [PDF]

Beilstein Journal of Organic Chemistry, 2017
In this review, the recent progress in the synthesis of ureas, thioureas and guanidines by solid-state mechanochemical ball milling is highlighted. While the literature is abundant on their preparation in conventional solution environment, it was not ...
Vjekoslav Štrukil
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Autocatalytic and oscillatory reaction networks that form guanidines and products of their cyclization

Nature Communications, 2021
So far, only a few chemical oscillators based on organic reactions have been developed. Here, the authors report both autocatalytic and oscillatory reaction networks that form substituted guanidines from thiouronium salts; when coupled to cascade ...
Alexander I. Novichkov, Anton I. Hanopolskyi, Xiaoming Miao, Linda J. W. Shimon, Yael Diskin-Posner, Sergey N. Semenov   +5 more
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Readily Available Chiral Benzimidazoles-Derived Guanidines as Organocatalysts in the Asymmetric α-Amination of 1,3-Dicarbonyl Compounds

Molecules, 2017
The synthesis and the evaluation as organocatalysts of new chiral guanidines derived from benzimidazoles in the enantioselective α-amination of 1,3-dicarbonyl compounds using di-t-butylazodicarboxylate as aminating agent is herein disclosed.
Llorenç Benavent, Francesco Puccetti, Alejandro Baeza, Melania Gómez-Martínez   +3 more
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Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency [PDF]

Pharmaceutics, 2011
Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-
Abdelkader A. Metwally, Ian S. Blagbrough   +1 more
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Derivatives of the triaminoguanidinium ion, 5. Acylation of triaminoguanidines leading to symmetrical tris(acylamino)guanidines and mesoionic 1,2,4-triazolium-3-aminides [PDF]

Beilstein Journal of Organic Chemistry, 2017
Depending on the reaction conditions, N,N’,N’’-tris(benzylamino)guanidinium salts can react with carboxylic acid chlorides to form either symmetrical N,N’,N’’-tris(N-acyl-N-benzylamido)guanidines 6 or mesoionic 4-amino-1,2,4-triazolium-3-hydrazinides 7 ...
Jan Szabo, Julian Greiner, Gerhard Maas
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Advanced glycation end products mediate biomineralization disorder in diabetic bone disease [PDF]

Cell Reports Medicine
Summary: Patients with diabetes often experience fragile fractures despite normal or higher bone mineral density (BMD), a phenomenon termed the diabetic bone paradox (DBP).
Qianmin Gao, Yingying Jiang, Dongyang Zhou, Guangfeng Li, Yafei Han, Jingzhi Yang, Ke Xu, Yingying Jing, Long Bai, Zhen Geng, Hao Zhang, Guangyin Zhou, Mengru Zhu, Ning Ji, Ruina Han, Yuanwei Zhang, Zuhao Li, Chuandong Wang, Yan Hu, Hao Shen, Guangchao Wang, Zhongmin Shi, Qinglin Han, Xiao Chen, Jiacan Su   +24 more
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Efficient Cleavage of pUC19 DNA by Tetraaminonaphthols [PDF]

ChemistryOpen
In an attempt to create models of phosphodiesterases, we previously investigated bis(guanidinium) naphthols. Such metal‐free anion receptors cleaved aryl phosphates and also plasmid DNA.
Catharina Kost, Ute Scheffer, Elisabeth Kalden, Michael Wilhelm Göbel   +3 more
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Mechanistic DFT Study of 1,3-Dipolar Cycloadditions of Azides with Guanidine

Molecules, 2023
Density functional calculations SMD(chloroform)//B3LYP/6-311+G(2d,p) were employed in the computational study of 1,3-dipolar cycloadditions of azides with guanidine.
Ivana Antol, Zoran Glasovac, Davor Margetić   +2 more
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Guanidines: Synthesis of Novel Histamine H₃R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect

Pharmaceuticals, 2023
This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets.
Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński   +12 more
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2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A small library of substituted cyclic guanidine incorporated benzothiazole-6-sulphonamides was synthesized. All obtained compounds were investigated for their inhibitory activity against the key brain-associated human carbonic anhydrase isoform hCA VII ...
Morteza Abdoli, Claudiu T. Supuran, Raivis Žalubovskis   +2 more
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