Results 91 to 100 of about 15,901 (303)

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Catalytic activation of pre-substrates via dynamic Fragment assembly on Protein templates [PDF]

, 2014
Sensitive detection of small molecule fragments binding to defined sites of biomacromolecules is still a considerable challenge. Here we demonstrate that protein-binding fragments are able to induce enzymatic reactions on the protein surface via dynamic ...
Burda, E., Rademann, Jörg
core   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, EarlyView.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Anticoccidial therapy small guide [PDF]

Medicamentul Veterinar, 2007
Being a major challenge, because of ingenious parasite's survival strategies and treatment's transience, anticoccidal therapy it is a major priority. In this respect, therapeutic conduct must be adjusted as well is possible on the most efficient drug ...
Cristina, T. Romeo
doaj  

11CO2 Fixation: A Renaissance in PET Radiochemistry [PDF]

, 2013
Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide.
Collier, Thomas L, Holland, Jason P, Hooker, Jacob M, Liang, Steven, Rotstein, Benjamin H, Vasdev, Neil, Wilson, Alan A.   +6 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Biochemical and clinical impact of organic uremic retention solutes : a comprehensive update [PDF]

, 2018
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized.
Abel, Amann, Anneleen Pletinck, Barreto, Brownlee, Cohen, Costigan, Dhaun, Drewett, Eva Schepers, Glorieux, Griet Glorieux, Hannam-Harris, Harpel, Henderson, Hur, Kassis, Kohan, Koizumi, Kuragano, Lim, Nilsson, Niwa, Niwa, Palmer, Patel, Raymond Vanholder, Rhee, Rock, Rubin, Saxena, Sheriff, Simenhoff, Tschesche, Vadas, Vallance, Vanholder, Vanholder, Vanholder, Vannucchi, Ward, Warren, Witko-Sarsat, Yan, Zoccali, Zoccali   +45 more
core   +3 more sources

Proton Affinities of Didehydroporphyrin and Subporphyrin in Ground and Excited States Obtained by Quantum Chemical Calculations [PDF]

, 2009
Quantum-chemical calculations were used to investigate molecular and electronic properties of porphyrin and subporphyrin. Their basicities were estimated in ground and excited states.
Glasovac, Zoran, Margetić, Davor, Vazdar, Mario   +2 more
core   +1 more source

Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors [PDF]

, 2018
Purpose: Sphingosine kinase 1 (SK1) is a protooncogenic enzyme expressed in many human tumours and is associated with chemoresistance and poor prognosis. It is a potent therapy target and its inhibition chemosensitises solid tumours.
A Datta, A Olivera, AH Merrill Jr, AJ Kennedy, AK Sharma, B Visentin, Bernard Malavaud, C Loveridge, C White, Caroline M. R. Low, CM Low, CMR Low, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, D Shida, DA Vessey, Danielle Monteil, DJ Baek, DJ Gustin, DL Baker, Dmitri Pchejetski, DR Adams, E Bonhoure, E Scolan Le, F Tonelli, F Tonelli, H Alshaker, H Alshaker, H Alshaker, H Alshaker, H Alshaker, H Alshaker, Heba Alshaker, J Hengst, J Nunes, JA Hengst, JD Wang, JL Martin, JR Brocklyn Van, JW Lee, K Budde, K Chiba, K Kono, K Rex, KJ French, KJ French, KR Johnson, L Fang, L Sauer, LC Chan, MA Dickson, ME Schnute, MG Bayerl, N Pyne, NJ Pyne, NN Patwardhan, O Cuvillier, O Cuvillier, O Itsenko, P Xia, P Xia, Q Wang, Qi Wang, S Murray, S Permpongkosol, Shyam Srivats, SW Paugh, SW Paugh, T Licht, Y Banno, Y Kharel, Y Xiang, Z Wang   +75 more
core   +1 more source

Rapid screening of melamine in dried milk without destroying the samples by Raman spectroscopy [PDF]

, 2009
Melamine is a raw ingredient for plastics, but it is frequently misused by adding it to food to give the false impression of a high protein content, since the molecule has a very high nitrogen content. Samples of dried milk obtained from 5 manufacturers
4698, 4699, 4700, 4701, 4702, Gonmori, Kunio, Hiramatsu, Mitsuo, Okazaki, Shigetoshi, Suzuki, Osamu, Tu, Anthony T.   +9 more
core   +2 more sources