Identifying the impact of G-quadruplexes on Affymetrix 3' arrays using cloud computing. [PDF]
, 2010 A tetramer quadruplex structure is formed by four parallel strands of DNA/ RNA containing runs of guanine. These quadruplexes are able to form because guanine can Hoogsteen hydrogen bond to other guanines, and a tetrad of guanines can form a stable ...
Harrison, AP +4 more
core +2 more sources
Single-Step Charge Transport through DNA over Long Distances [PDF]
, 2011 Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides between photoexcited 2-aminopurine, a fluorescent analogue of adenine, and N_2-cyclopropyl ...
Barton, Jacqueline K. +2 more
core +2 more sources
Interaction of low-energy electrons with the purine bases, nucleosides, and nucleotides of DNA [PDF]
, 2006 The authors report results from computational studies of the interaction of low-energy electrons with the purine bases of DNA, adenine and guanine, as well as with the associated nucleosides, deoxyadenosine and deoxyguanosine, and the nucleotide ...
McKoy, Vincent, Winstead, Carl
core +1 more source
Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine [PDF]
Molecules, 2012 DNA is constantly exposed to endogenous and exogenous oxidative stresses. Damaged DNA can cause mutations, which may increase the risk of developing cancer and other diseases. G:C-C:G transversions are caused by various oxidative stresses. 2,2,4-Triamino-5(2H)-oxazolone (Oz), guanidinohydantoin (Gh)/iminoallantoin (Ia) and spiro-imino-dihydantoin (Sp ...
Suzuki, Masayo +5 more
openaire +4 more sources
Structure of isolated biomolecules by electron diffraction-laser desorption: uracil and guanine [PDF]
, 2009 We report the structure of isolated biomolecules, uracil and guanine, demonstrating the capability of a newly developed electron diffraction apparatus augmented with surface-assisted IR laser desorption.
Gahlmann, Andreas +2 more
core +1 more source
Predicting the effects of basepair mutations in DNA-protein complexes by thermodynamic integration [PDF]
, 2011 Thermodynamically rigorous free energy methods in principle allow the exact computation of binding free energies in biological systems. Here, we use thermodynamic integration together with molecular dynamics simulations of a DNA-protein complex to ...
Beierlein, F., Clark, Tim, Kneale, Geoff
core +1 more source
Biomineralization and Properties of Guanine Crystals
Molecules, 2023 Guanine crystals with unique optical properties in organisms have been extensively studied and the biomineralization principles of guanine are being established. This review summarizes the fundamental physicochemical properties (solubility, tautomers, bands, and refractivity), polymorphs, morphology of biological and synthetic forms, and the reported ...
Haoxin Hu, Rongrong Xue, Fenghua Chen
openaire +3 more sources
Guanine in Fishes' Skins [PDF]
Nature, 1895 IN a joint paper by Mr. J. T. Cunningham and myself (Phil. Trans. vol. clxxxiv., 1893, B, pp. 765–812), we have ventured to question the accuracy of the statement made in many text-books of physiological chemistry, that guanine occurs in combination with calcium in the skin of fishes. We found that the guanine occurs in the free state.
openaire +3 more sources
Fluorescent turn-on probes for wash-free mRNA imaging via covalent site-specific enzymatic labeling. [PDF]
, 2017 Investigating the many roles RNA plays in cellular regulation and function has increased demand for tools to explore RNA tracking and localization within cells.
Alexander, Seth C +2 more
core +2 more sources
Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]
, 2013 The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E. +42 more
core +1 more source