Results 21 to 30 of about 159,037 (219)

Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B

open access: yesGut and Liver, 2020
Background/Aims: Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF).
Young Youn Cho   +8 more
doaj   +1 more source

Concurrent use of rabacfosadine and L‐asparaginase for relapsed or refractory multicentric lymphoma in dogs

open access: yesJournal of Veterinary Internal Medicine, 2020
Background Rabacfosadine (RAB), a novel antineoplastic agent conditionally licensed for the treatment of lymphoma in dogs, is efficacious in both naïve and previously treated dogs.
Jacob R. Cawley   +8 more
doaj   +1 more source

Eco-Friendly Synthesis of Nitrogen-Doped Mesoporous Carbon for Supercapacitor Application

open access: yesC, 2018
A sustainable and simple synthesis procedure involving the co-assembly of green phenolic resin and amphiphilic polymer template in water/ethanol mixture at room temperature to synthesize nitrogen doped mesoporous carbon is reported herein.
Georges Moussa   +4 more
doaj   +1 more source

Uncovering the Signaling Pathway behind Extracellular Guanine-Induced Activation of NO System: New Perspectives in Memory-Related Disorders

open access: yesFrontiers in Pharmacology, 2018
Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases.
Mariachiara Zuccarini   +18 more
doaj   +1 more source

Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study

open access: yesBibechana, 2022
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
doaj   +3 more sources

Ab-initio study of model guanine assemblies: The role of pi-pi coupling and band transport [PDF]

open access: yesPhysical Review B 65, 045104 (2002), 2001
Several assemblies of guanine molecules are investigated by means of first-principle calculations. Such structures include stacked and hydrogen-bonded dimers, as well as vertical columns and planar ribbons, respectively, obtained by periodically replicating the dimers.
arxiv   +1 more source

Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives [PDF]

open access: yesProceedings of the National Academy of Sciences, 2015
Significance Guanine-rich nucleic acids fold into a four-stranded structure named G-quadruplex that has implications in essential cellular processes, pharmaceutical applications, and nanodevices. We found a unique type of G-quadruplex that contains a G-vacancy and is stabilized by guanine derivatives such as te physiological concentration of ...
Xin-min Li   +7 more
openaire   +3 more sources

NupR Responding to Multiple Signals Is a Nucleoside Permease Regulator in Bacillus thuringiensis BMB171

open access: yesMicrobiology Spectrum, 2022
Nucleoside transport is essential for maintaining intracellular nucleoside and nucleobase homeostasis for living cells. Here, we identified an uncharacterized GntR/HutC family transcriptional regulator, NagR2, renamed NupR (nucleoside permease regulator),
Jiaxin Qin   +10 more
doaj   +1 more source

Calculating Hyperfine Couplings in Large Ionic Crystals Containing Hundreds of QM Atoms: Subsystem DFT is the Key [PDF]

open access: yesv. 117, p.ASAP, y. 2013, Journal of Physical Chemistry B, 2013
We present an application of the linear scaling Frozen Density Embedding (FDE) formulation of subsystem DFT to the calculation of isotropic hyperfine coupling constants (hfccs) of atoms belonging to a guanine radical cation embedded in a guanine hydrochloride monohydrate crystal.
arxiv   +1 more source

Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations [PDF]

open access: yes, 2022
The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a vital role in the epigenetic control of gene expression and is believed to be associated with mutagenesis, carcinogenesis, and ageing. To understand the microscopic structural changes in physical properties of DNA and the resulting influence on its function due to ...
arxiv   +1 more source

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