Results 21 to 30 of about 316,659 (284)

Interaction of low-energy electrons with the purine bases, nucleosides, and nucleotides of DNA [PDF]

, 2006
The authors report results from computational studies of the interaction of low-energy electrons with the purine bases of DNA, adenine and guanine, as well as with the associated nucleosides, deoxyadenosine and deoxyguanosine, and the nucleotide ...
McKoy, Vincent, Winstead, Carl
core   +1 more source

The Two Faces of the Guanyl Radical: Molecular Context and Behavior

Molecules, 2021
The guanyl radical or neutral guanine radical G(-H)• results from the loss of a hydrogen atom (H•) or an electron/proton (e–/H+) couple from the guanine structures (G). The guanyl radical exists in two tautomeric forms.
Chryssostomos Chatgilialoglu
doaj   +1 more source

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study

Bibechana, 2022
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
doaj   +3 more sources

NupR Responding to Multiple Signals Is a Nucleoside Permease Regulator in Bacillus thuringiensis BMB171

Microbiology Spectrum, 2022
Nucleoside transport is essential for maintaining intracellular nucleoside and nucleobase homeostasis for living cells. Here, we identified an uncharacterized GntR/HutC family transcriptional regulator, NagR2, renamed NupR (nucleoside permease regulator),
Jiaxin Qin, Zhanglei Cao, Xia Cai, Yu Fang, Baoju An, Xuelian Li, Yizhuo Zhang, Hongwei Tian, Wenzhuo Hu, Bing Yan, Jun Cai   +10 more
doaj   +1 more source

Detection of Guanine and Adenine Using an Aminated Reduced Graphene Oxide Functional Membrane-Modified Glassy Carbon Electrode

Sensors, 2017
A new electrochemical sensor based on a Nafion, aminated reduced graphene oxide and chitosan functional membrane-modified glassy carbon electrode was proposed for the simultaneous detection of adenine and guanine. Fourier transform-infrared spectrometry (
Di Li, Xiao-Lu Yang, Bao-Lin Xiao, Fang-Yong Geng, Jun Hong, Nader Sheibani, Ali Akbar Moosavi-Movahedi   +6 more
doaj   +1 more source

Electrochemical antioxidant screening and evaluation based on guanine and chitosan immobilized MoS2 nanosheet modified glassy carbon electrode (guanine/CS/MoS2/GCE)

Open Chemistry, 2020
In this study, an electrochemical biosensor based on guanine and chitosan immobilized MoS2 nanosheet modified glassy carbon electrode (guanine/CS/MoS2/GCE) was developed and employed for antioxidant screening and antioxidant capacity evaluation.
Tang Ping, Tang Xiaosheng, Mei Shiyong, Xie Yixi, Liu Liangliang, Ren Licheng   +5 more
doaj   +1 more source

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Química Nova, 2010
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA.
Maria Lara P. M. Arguelho, José do Patrocínio H. Alves, Nelson R. Stradiotto, Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz   +5 more
doaj   +1 more source

Silica nanochannels boosting Ru(bpy)32+-mediated electrochemical sensor for the detection of guanine in beer and pharmaceutical samples

Frontiers in Nutrition, 2022
Vertically ordered mesoporous silica film (VMSF) with uniform mesoporous channels perpendicular to electrode substrate has a wide range of applications in direct electroanalysis of complex samples.
Luoxing Yang, Tongtong Zhang, Huaxu Zhou, Fei Yan, Yan Liu   +4 more
doaj   +1 more source

Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]

, 2012
Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose, George G. Dougherty, Jeffrey K. Yao, Joseph McEvoy, Kenji Hashimoto, Matcheri S. Keshavan, Ravinder D. Reddy, Rima Kaddurah-Daouk, Ruth Condray, Wayne R. Matson   +9 more
core   +3 more sources