Results 21 to 30 of about 159,037 (219)
Gut and Liver, 2020 Background/Aims: Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF).
Young Youn Cho +8 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2020 Background Rabacfosadine (RAB), a novel antineoplastic agent conditionally licensed for the treatment of lymphoma in dogs, is efficacious in both naïve and previously treated dogs.
Jacob R. Cawley +8 more
doaj +1 more source
Eco-Friendly Synthesis of Nitrogen-Doped Mesoporous Carbon for Supercapacitor Application
C, 2018 A sustainable and simple synthesis procedure involving the co-assembly of green phenolic resin and amphiphilic polymer template in water/ethanol mixture at room temperature to synthesize nitrogen doped mesoporous carbon is reported herein.
Georges Moussa +4 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases.
Mariachiara Zuccarini +18 more
doaj +1 more source
Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
doaj +3 more sources
Ab-initio study of model guanine assemblies: The role of pi-pi coupling and band transport [PDF]
Physical Review B 65, 045104 (2002), 2001 Several assemblies of guanine molecules are investigated by means of first-principle calculations. Such structures include stacked and hydrogen-bonded dimers, as well as vertical columns and planar ribbons, respectively, obtained by periodically replicating the dimers.
arxiv +1 more source
Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Guanine-rich nucleic acids fold into a four-stranded structure named G-quadruplex that has implications in essential cellular processes, pharmaceutical applications, and nanodevices. We found a unique type of G-quadruplex that contains a G-vacancy and is stabilized by guanine derivatives such as te physiological concentration of ...
Xin-min Li +7 more
openaire +3 more sources
Microbiology Spectrum, 2022 Nucleoside transport is essential for maintaining intracellular nucleoside and nucleobase homeostasis for living cells. Here, we identified an uncharacterized GntR/HutC family transcriptional regulator, NagR2, renamed NupR (nucleoside permease regulator),
Jiaxin Qin +10 more
doaj +1 more source
Calculating Hyperfine Couplings in Large Ionic Crystals Containing Hundreds of QM Atoms: Subsystem DFT is the Key [PDF]
v. 117, p.ASAP, y. 2013, Journal of Physical Chemistry B, 2013 We present an application of the linear scaling Frozen Density Embedding (FDE) formulation of subsystem DFT to the calculation of isotropic hyperfine coupling constants (hfccs) of atoms belonging to a guanine radical cation embedded in a guanine hydrochloride monohydrate crystal.
arxiv +1 more source
Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations [PDF]
, 2022 The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a vital role in the epigenetic control of gene expression and is believed to be associated with mutagenesis, carcinogenesis, and ageing. To understand the microscopic structural changes in physical properties of DNA and the resulting influence on its function due to ...
arxiv +1 more source