Results 41 to 50 of about 201,610 (282)
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.
Genes & Development, 2002 Rho GTPases control many aspects of cell behavior through the regulation of multiple signal transduction pathways (Van Aelst and D’Souza-Schorey 1997; Hall 1998).
A. Schmidt, A. Hall
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Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine [PDF]
Molecules, 2012 DNA is constantly exposed to endogenous and exogenous oxidative stresses. Damaged DNA can cause mutations, which may increase the risk of developing cancer and other diseases. G:C-C:G transversions are caused by various oxidative stresses. 2,2,4-Triamino-5(2H)-oxazolone (Oz), guanidinohydantoin (Gh)/iminoallantoin (Ia) and spiro-imino-dihydantoin (Sp ...
Suzuki, Masayo +5 more
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Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate
Acta Crystallographica Section E: Crystallographic Communications, 2023 The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
doaj +1 more source
The Origin of Life: Models and Data. [PDF]
, 2017 A general framework for conventional models of the origin of life (OOL) is the specification of a 'privileged function.' A privileged function is an extant biological function that is excised from its biological context, elevated in importance over other
Lanier, Kathryn A, Williams, Loren Dean
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Neuromodulatory Effects of Guanine-Based Purines in Health and Disease
Frontiers in Cellular Neuroscience, 2018 The function of guanine-based purines (GBPs) is mostly attributed to the intracellular modulation of heteromeric and monomeric G proteins. However, extracellular effects of guanine derivatives have also been recognized.
C. Tasca +4 more
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Reductionsproducte aus Guanin [PDF]
Berichte der deutschen chemischen Gesellschaft, 1901 n ...
Tafel, Julius, Ach, Benno
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A new possible way for cancer cure – DNA four strand [PDF]
World Cancer Research Journal, 2019 DNA is the active ingredient of all the biological operations of the cell because it stores genetic information in the configuration of genes. It is a very well recognized fact that DNA has a double-helical structure; recently, it was reported to have ...
P. Amit, K. Prerna, S. Anita, S. Kumar
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Unusual DNA binding modes for metal anticancer complexes [PDF]
, 2009 DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
Nature Communications, 2018 Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown.
A. F. Voter +4 more
semanticscholar +1 more source
Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]
, 2009 Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K. +2 more
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