Guanine nucleotide exchange factors and colon neoplasia [PDF]
Frontiers in Cell and Developmental BiologyDespite many diagnostic and therapeutic advances, colorectal cancer (CRC) remains the second leading cause of cancer death for men and women in the United States.
Lea-Pearl Njei +8 more
doaj +4 more sources
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration [PDF]
Nature Communications, 2016 The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the ...
Hadir Marei +7 more
doaj +4 more sources
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]
Nature Communications, 2017 Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and ...
Alain Ibáñez de Opakua +14 more
doaj +2 more sources
Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement [PDF]
Frontiers in Cell and Developmental Biology, 2023 In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba
Dhiman Sankar Pal +10 more
doaj +2 more sources
Activation of G Proteins by Guanine Nucleotide Exchange Factors Relies on GTPase Activity. [PDF]
PLoS ONE, 2016 G proteins are an important family of signalling molecules controlled by guanine nucleotide exchange and GTPase activity in what is commonly called an 'activation/inactivation cycle'.
Rob J Stanley, Geraint M H Thomas
doaj +2 more sources
The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review [PDF]
Frontiers in Cardiovascular Medicine, 2022 Atherosclerosis is a leading cause of cardiovascular disease, and atherosclerotic cardiovascular disease accounts for one-third of global deaths. However, the mechanism of atherosclerosis is not fully understood.
Mengqi Li +9 more
doaj +2 more sources
The Emerging Role of Guanine Exchange Factors in ALS and other neurodegenerative diseases [PDF]
Frontiers in Cellular Neuroscience, 2014 Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide ...
Cristian eDroppelmann +5 more
doaj +2 more sources
Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets [PDF]
MedCommGuanine nucleotide exchange factors (GEFs) and their small GTPase substrates constitute a fundamental regulatory system that governs diverse cellular processes, including cytoskeletal dynamics, membrane trafficking, and transcriptional regulation.
Zexing Lin +15 more
doaj +2 more sources
Non-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factors. [PDF]
PLoS ONE, 2014 Non-muscle myosin II (NM II) regulates a wide range of cellular functions, including neuronal differentiation, which requires precise spatio-temporal activation of Rho GTPases.
Eun-Young Shin +7 more
doaj +2 more sources
Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells. [PDF]
Small GTPases, 2021 Reinhard NR +6 more
europepmc +3 more sources