Results 21 to 30 of about 84,425 (312)

RasGRP Ras guanine nucleotide exchange factors in cancer. [PDF]

Front Biol (Beijing), 2013
RasGRP proteins are activators of Ras and other related small GTPases by the virtue of functioning as guanine nucleotide exchange factors (GEFs). In vertebrates, four RasGRP family members have been described. RasGRP-1 through -4 share many structural domains but there are also subtle differences between each of the different family members.
Ksionda O, Limnander A, Roose JP.
europepmc   +6 more sources

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain [PDF]

Molecular Brain, 2018
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain.
Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka   +6 more
doaj   +2 more sources

Scambio, a novel guanine nucleotide exchange factor for Rho

Molecular Cancer, 2004
Background Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis.
Groffen John, Senadheera Dinithi, Haataja Leena, Hemmeryckx Bianca, Curtis Christina, Heisterkamp Nora   +5 more
doaj   +3 more sources

Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors. [PDF]

Mol Pharmacol, 2021
Aguilar Mora FA, Musheshe N, Oun A, Buist-Homan M, Lezoualc'h F, Cheng X, Schmidt M, Moshage H.   +7 more
europepmc   +3 more sources

Editorial: Guanine nucleotide exchange factors as determinants of cell fate and development [PDF]

Frontiers in Cell and Developmental Biology
Vegesna Radha, Katsuhiko Tabuchi, Katsuhiko Tabuchi, Jacek Z. Kubiak, Jacek Z. Kubiak   +4 more
doaj   +2 more sources

SH3-class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth. [PDF]

Cell Microbiol, 2019
Martin-Vicente A, Souza ACO, Al Abdallah Q, Ge W, Fortwendel JR.   +4 more
europepmc   +3 more sources

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. [PDF]

Proc Natl Acad Sci U S A, 2013
Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y.   +7 more
europepmc   +3 more sources

Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors. [PDF]

Cell Cycle, 2016
Marei H, Carpy A, Macek B, Malliri A.
europepmc   +2 more sources

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

Genetic analysis of GEFs and GDIs in rice reveals the roles of OsGEF5, OsGDI1, and OsGEF3 in the regulation of grain size and plant height

Crop Journal, 2023
Guanine nucleotide exchange factors (GEFs) and guanine nucleotide-dissociation inhibitors (GDIs) regulate small GTPase proteins, which function as molecular switches in various signaling pathways, but their identification and functions in plants are not ...
Munsif Ali Shad, Yixian Wang, Hui Zhang, Shanshan Zhai, Abdullah Shalmani, Yibo Li   +5 more
doaj   +1 more source