Results 111 to 120 of about 98,650 (296)

Expression, purification, crystallization and X-ray data collection for RAS and its mutants

Data in Brief, 2016
This article expands on crystal structure data for human H-RAS with mutations at position Y137, briefly described in a paper on the effects of phosphorylation of Y137 by ABL kinases (Tyrosine phosphorylation of RAS by ABL allosterically enhances effector
Christian W. Johnson, Greg Buhrman, Pamela Y. Ting, John Colicelli, Carla Mattos   +4 more
doaj   +1 more source

LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2. [PDF]

Int J Biol Sci, 2023
Liu SS, Li JS, Xue M, Wu WJ, Li X, Chen W.   +5 more
europepmc   +1 more source

Noonan Syndrome Spectrum Disorders Predispose to Systemic Lupus Erythematosus: Case Report and Critical Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT RASopathies are clinically overlapping neurodevelopmental syndromes resulting from germline mutations in genes involved in the rat sarcoma/mitogen‐activated protein kinases (RAS/MAPK) pathway. Historically, RASopathies have been described by clinical phenotypes, such as Noonan syndrome and Neurofibromatosis type I.
Anastasia‐Vasiliki Madenidou, Gillian I. Rice, James O'Sullivan, Ben Parker, Ian N. Bruce, Emma Burkitt‐Wright, Tracy A. Briggs   +6 more
wiley   +1 more source

HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase. [PDF]

Anal Biochem, 2021
Hannan JP, Swisher GH, Martyr JG, Cordaro NJ, Erbse AH, Falke JJ.   +5 more
europepmc   +1 more source

Nanostructured Lipid Carriers Overcome the Low Immunogenicity of M2e Peptide via Surface Click Chemistry Conjugation, Improving the Anti‐M2e Antibody Response

Advanced NanoBiomed Research, EarlyView.
1) Nanostructured lipid carriers efficiently vectorize low‐immunogenic M2e peptide. 2) M2e peptide conjugation via click chemistry preserves the peptide key epitopes. 3) Forty M2e peptides per nanoparticle are sufficient to induce robust immune responses.
Louis Bourlon, Carole Fournier, Antoine Hoang, Christine Charrat, Alban Lepetitcolin, Jessica Morlieras, Fabrice Navarro, Patrice N. Marche   +7 more
wiley   +1 more source

Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence.

PLoS ONE, 2015
In recent years, the number of human infection cases produced by the food related species Saccharomyces cerevisiae has increased. Whereas many strains of this species are considered safe, other 'opportunistic' strains show a high degree of potential ...
Roberto Pérez-Torrado, Silvia Llopis, Benedetta Perrone, Rocío Gómez-Pastor, Bernhard Hube, Amparo Querol   +5 more
doaj   +1 more source

Food-chain competition influences gene's size

, 2006
We have analysed an effect of the Bak-Sneppen predator-prey food-chain self-organization on nucleotide content of evolving species. In our model, genomes of the species under consideration have been represented by their nucleotide genomic fraction and we
Bak, Chowdhury, Dietrich Stauffer, Gierlik, Harrison, Ito, Kimura, Kimura, Lobry, Lobry, Marta Dembska, Mirosław R. Dudek, Rzhetsky, Stauffer, Wen-Hsiung Li, Wen-Hsiung Li, Wentian Li   +16 more
core   +1 more source

Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase. [PDF]

Protein Sci, 2022
Fernández-Justel D, Marcos-Alcalde Í, Abascal F, Vidaña N, Gómez-Puertas P, Jiménez A, Revuelta JL, Buey RM.   +7 more
europepmc   +1 more source

Identifizierung und Charakterisierung eines neuen Bindeproteins für zyklische Nukleotide [PDF]

, 2007
Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate are important intracellular messengers. Binding of cyclic nucleotides controls the activity of protein kinases, ion channels and guanine-nucleotide-exchange factors in many cells ...
Debowski, Katharina
core  

Kontrollierter Transport und lichtinduzierte Freisetzung von Magic Spot Nukleotiden in Escherichia coli

Angewandte Chemie, EarlyView.
We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp, Patrick Moser, Anselm Schwoerbel, Xinwei Liu, Johannes Freitag, Pinku Sarmah, Isabel Prucker, Robert Zscherp, Xuan Wang, Philipp Klahn, Hans‐Georg Koch, Gert Bange, Henning J. Jessen   +12 more
wiley   +1 more source