Results 11 to 20 of about 99,476 (367)

Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase [PDF]

Biomolecules, 2022
The final maturation step of the 60S ribosomal subunit requires the release of eukaryotic translation initiation factor 6 (human eIF6, yeast Tif6) to enter the pool of mature ribosomes capable of engaging in translation.
Jesús Pérez-Juárez, Juana Virginia Tapia-Vieyra, Gabriel Gutiérrez-Magdaleno, Nuria Sánchez-Puig   +3 more
doaj   +2 more sources

Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. [PDF]

PLoS ONE, 2014
In this study, we compared the influence of GDP and GTP on isolated mitochondria respiring under conditions favoring oxidative phosphorylation (OXPHOS) and under conditions excluding this process, i.e., in the presence of carboxyatractyloside, an adenine
Andrzej M Woyda-Ploszczyca, Wieslawa Jarmuszkiewicz   +1 more
doaj   +2 more sources

Determination of the Global Pattern of Gene Expression in Yeast Cells by Intracellular Levels of Guanine Nucleotides [PDF]

mBio, 2019
Correlations between gene transcription and the abundance of high-energy purine nucleotides in Saccharomyces cerevisiae have often been noted. However, there has been no systematic investigation of this phenomenon in the absence of confounding factors ...
Andy Hesketh, Marta Vergnano, Stephen G. Oliver   +2 more
doaj   +2 more sources

Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition [PDF]

Nature Communications
Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases.
Xiangguo Shi, Minhua Li, Zian Liu, Jonathan Tiessen, Yuan Li, Jing Zhou, Yudan Zhu, Swetha Mahesula, Qing Ding, Lin Tan, Mengdie Feng, Yuki Kageyama, Yusuke Hara, Jacob J. Tao, Xuan Luo, Kathryn A. Patras, Philip L. Lorenzi, Suming Huang, Alexandra M. Stevens, Koichi Takahashi, Ghayas C. Issa, Md. Abul Hassan Samee, Michalis Agathocleous, Daisuke Nakada   +23 more
doaj   +2 more sources

Novel Mutation at Cys225 in GNAO1‐Associated Developmental and Epileptic Encephalopathies: Clinical, Molecular, and Pharmacological Profiling of Case Studies [PDF]

MedComm
GNAO1‐associated disorders have a large spectrum of neurological symptoms, from early‐onset developmental and epileptic encephalopathies (DEE) to late‐onset movement disorders. First reported in 2013 and now identified in around 400 cases worldwide, this
Yonika A. Larasati, Gonzalo P. Solis, Alexey Koval, Marie‐Céline François‐Heude, Julie Piarroux, Agathe Roubertie, Ruihan Yang, Ying Zhang, Dezhi Cao, Christian M. Korff, Vladimir L. Katanaev   +10 more
doaj   +2 more sources

A single nucleotide polymorphism produces different transcription profiles in Campylobacter jejuni’s cysM [PDF]

Frontiers in Microbiology
A single nucleotide polymorphism (SNP) in the 126 bp untranslated region (UTR) directly upstream of Campylobacter jejuni’s cysM (cysteine synthase) results in significant effects on gene transcription.
Nereus W. Gunther IV, Siddhartha Kanrar, Aisha Abdul-Wakeel, Michael J. McAnulty, John Renye, Joseph Uknalis, Gaylen A. Uhlich   +6 more
doaj   +2 more sources

Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. [PDF]

PLoS Pathogens, 2010
Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain.
Jérôme Mulhbacher, Eric Brouillette, Marianne Allard, Louis-Charles Fortier, François Malouin, Daniel A Lafontaine   +5 more
doaj   +1 more source

Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites

Guangdong nongye kexue, 2023
Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU, Siyun FANG, Mingfei SUN, Nanshan QI, Wenjun LIU, Juan LI, Junjing HU, Shenquan LIAO   +7 more
doaj   +1 more source

Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations [PDF]

, 2022
The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a vital role in the epigenetic control of gene expression and is believed to be associated with mutagenesis, carcinogenesis, and ageing. To understand the microscopic structural changes in physical properties of DNA and the resulting influence on its function due to ...
arxiv   +1 more source

Identification of discriminant features from stationary pattern of nucleotide bases and their application to essential gene classification

Frontiers in Genetics, 2023
Introduction: Essential genes are essential for the survival of various species. These genes are a family linked to critical cellular activities for species survival.
Ranjeet Kumar Rout, Saiyed Umer, Monika Khandelwal, Smitarani Pati, Saurav Mallik, Saurav Mallik, Bunil Kumar Balabantaray, Hong Qin   +7 more
doaj   +1 more source