Results 11 to 20 of about 98,650 (296)

Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir

The Innovation, 2021
Summary: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogs, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs ...
Qi Peng, Ruchao Peng, Bin Yuan, Min Wang, Jingru Zhao, Lifeng Fu, Jianxun Qi, Yi Shi   +7 more
doaj   +1 more source

Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites

Guangdong nongye kexue, 2023
Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU, Siyun FANG, Mingfei SUN, Nanshan QI, Wenjun LIU, Juan LI, Junjing HU, Shenquan LIAO   +7 more
doaj   +1 more source

Essential role of GTP in epinephrine stimulation of human fat cell adenylate cyclase

Journal of Lipid Research, 1981
The activity of epinephrine-sensitive adenylate cyclase of human fat cell ghosts is markedly enhanced by the GTP analog 5'-guanylyl-imidodiphosphate (GMP-P(NH)P), but a similar effect of GTP itself has not been heretofore demonstrable.
M S Katz, J S Partilla, M A Piñeyro, R I Gregerman   +3 more
doaj   +1 more source

Identification of discriminant features from stationary pattern of nucleotide bases and their application to essential gene classification

Frontiers in Genetics, 2023
Introduction: Essential genes are essential for the survival of various species. These genes are a family linked to critical cellular activities for species survival.
Ranjeet Kumar Rout, Saiyed Umer, Monika Khandelwal, Smitarani Pati, Saurav Mallik, Saurav Mallik, Bunil Kumar Balabantaray, Hong Qin   +7 more
doaj   +1 more source

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]

, 2006
Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas, Buck, Janina, Fürtig, Boris, Nasiri, Hamid Reza, Schwalbe, Harald (Prof. Dr.), Wöhnert, Jens   +5 more
core   +1 more source

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

Guanine nucleotides and acute renal failure [PDF]

Journal of Clinical Investigation, 2001
Sustained ischemic and nephrotoxic acute renal failure (ARF) are characterized by overt damage to renal tubules, including cell necrosis. As a result, these processes have frequently been termed acute tubular necrosis, but this description has long been known to be misleading, as much of the tubule damage is sublethal, and the extent of necrotic cell ...
J M, Weinberg, M A, Venkatachalam
openaire   +2 more sources

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source

Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP

Bio-Protocol, 2018
GTPases are molecular switches that cycle between the inactive GDP-bound state and the active GTP-bound state. GTPases exchange nucleotides either by its intrinsic nucleotide exchange or by interaction with guanine nucleotide exchange factors (GEFs ...
Tomoharu Kanie, Peter Jackson
doaj   +1 more source

Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Nature Communications, 2020
Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and
Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P. Rambo, Susumu Uchiyama, Kentaro Ishii, Shigenori Nishimura, Takashi Inui   +12 more
doaj   +1 more source