Results 11 to 20 of about 104,742 (325)
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
Nature Communications, 2021 Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ...
Hongxu Ding +4 more
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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. [PDF]
PLoS Pathogens, 2010 Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain.
Jérôme Mulhbacher +5 more
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Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
The Innovation, 2021 Summary: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogs, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs ...
Qi Peng +7 more
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Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
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Essential role of GTP in epinephrine stimulation of human fat cell adenylate cyclase
Journal of Lipid Research, 1981 The activity of epinephrine-sensitive adenylate cyclase of human fat cell ghosts is markedly enhanced by the GTP analog 5'-guanylyl-imidodiphosphate (GMP-P(NH)P), but a similar effect of GTP itself has not been heretofore demonstrable.
M S Katz +3 more
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Frontiers in Genetics, 2023 Introduction: Essential genes are essential for the survival of various species. These genes are a family linked to critical cellular activities for species survival.
Ranjeet Kumar Rout +7 more
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Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi +34 more
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Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]
, 2009 Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K. +2 more
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Guanine nucleotides and acute renal failure [PDF]
Journal of Clinical Investigation, 2001 Sustained ischemic and nephrotoxic acute renal failure (ARF) are characterized by overt damage to renal tubules, including cell necrosis. As a result, these processes have frequently been termed acute tubular necrosis, but this description has long been known to be misleading, as much of the tubule damage is sublethal, and the extent of necrotic cell ...
J M, Weinberg, M A, Venkatachalam
openaire +2 more sources
Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP
Bio-Protocol, 2018 GTPases are molecular switches that cycle between the inactive GDP-bound state and the active GTP-bound state. GTPases exchange nucleotides either by its intrinsic nucleotide exchange or by interaction with guanine nucleotide exchange factors (GEFs ...
Tomoharu Kanie, Peter Jackson
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