Results 271 to 280 of about 99,476 (367)

The diagnosis and treatment of disorders of nucleic acid/nucleotide metabolism associated with epilepsy. [PDF]

Acta Epileptol
Shi Y, Wei Z, Feng Y, Gan Y, Li G, Deng Y.   +5 more
europepmc   +1 more source

Stabilization of the catalytically active structure of a molybdenum‐dependent formate dehydrogenase depends on a highly conserved lysine residue

The FEBS Journal, EarlyView.
Molybdenum‐dependent formate dehydrogenases (Mo‐FDHs) contain a strictly conserved lysine residue (K44) in the vicinity of an electron‐transferring [4Fe‐4S] cluster and a catalytically active molybdenum atom coordinated by two molybdopterins (MPT‐1 and MPT‐2).
Feilong Li, Michael Lienemann
wiley   +1 more source

Crystal structures reveal nucleotide-induced conformational changes in G motifs and distal regions in human guanylate-binding protein 2. [PDF]

Commun Biol
Roy S, Wang B, Roy K, Tian Y, Bhattacharya M, Williams S, Yin Q.   +6 more
europepmc   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Mutations of the ras gene product p21 that abolish guanine nucleotide binding.

, 1986
David J. Clanton, Satoshi Hattori, Thomas Y. Shih   +2 more
openalex   +1 more source

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity. [PDF]

mBio
She F, Liu K, Anderson BW, Pisithkul T, Li Y, Fung DK, McCue T, Mulhern W, Amador-Noguez D, Wang JD.   +9 more
europepmc   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

The FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány, Anita Szőke, Aladár Pettkó‐Szandtner, Eszter Éva Kálmán, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi   +6 more
wiley   +1 more source

Polymeric Properties of Telomeric G-Quadruplex Multimers: Effects of Chemically Inert Crowders. [PDF]

Biomacromolecules
Mostarac D, Trapella M, Bertini L, Comez L, Paciaroni A, De Michele C.   +5 more
europepmc   +1 more source

Gαs‐specific structural elements attenuate interactions with regulator of G protein signaling (RGS) proteins

The FEBS Journal, EarlyView.
Heterotrimeric (αβγ) G proteins are usually inactivated by regulators of G protein signaling (RGS) proteins, but Gαs is an exception. Comparative structural analysis identified unique Gαs structural elements that may interfere with RGS binding. Mutagenesis and biochemical assays showed that three residues in the Gαs GTPase domain are both necessary and
Sabreen Higazy‐Mreih, Meirav Avital‐Shacham, Christian LeGouill, Michel Bouvier, Mickey Kosloff   +4 more
wiley   +1 more source

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides. [PDF]

EMBO J
Jones SA, Sowton AP, Lacabanne D, King MS, Palmer SM, Zögg T, Pardon E, Steyaert J, Ruprecht JJ, Kunji ERS.   +9 more
europepmc   +1 more source