Results 271 to 280 of about 104,742 (325)

Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand‐Displacement Reaction

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Capture‐SELEX for ampicillin aptamers led to the dominance of a low‐affinity aptamer, while extending the target‐library incubation time significantly increased the abundance of a high‐affinity aptamer, revealing a previously unrecognized kinetic effect in the DNA strand displacement reaction during SELEX.
Yuzhe Ding, Yicheng Heng, Ka‐Ying Wong, Qingyu Chen, Juewen Liu   +4 more
wiley   +2 more sources

G4STAB: a multi-input deep learning model to predict G-quadruplex thermodynamic stability based on sequence and salt concentration. [PDF]

Bioinformatics
Liew D, Dharmatilleke AD, See E, Yong EH.   +3 more
europepmc   +1 more source

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency

New Phytologist, Volume 249, Issue 3, Page 1325-1341, February 2026.
Summary This study characterizes the function of a grass‐specific E3 ubiquitin ligase, HvST1, in regulating synapsis and crossover (CO) formation during meiosis in barley (Hordeum vulgare). In large‐genome cereals, COs are predominantly restricted to distal chromosomal regions, limiting genetic recombination and breeding flexibility.
Jamie Neil Orr, Sybille Ursula Mittmann, Luke Ramsay, Dominika Lewandowska, Abdellah Barakate, Malcolm Macaulay, Nicola McCallum, Robbie Waugh, Isabelle Colas   +8 more
wiley   +1 more source

Kinetic analysis of catalytic activity of G-quadruplex/hemin DNAzyme with flanking adenine nucleotides. [PDF]

Sci Rep
Udomprasert A, Chimasungkanun S, Kangsamaksin T.   +2 more
europepmc   +1 more source

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai, Dongjie Sun, Yanxiao Zhao, Mengtao Zhang, Yifan Wu, Jiabo Ding   +5 more
wiley   +1 more source

The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology. [PDF]

J Clin Invest
Kager L, Boztug K.
europepmc   +1 more source

Exploring Guanidinium Group Involvement in Hordatine Interactions with the G-Quadruplex Motif Within the c-MYC Promoter Region. [PDF]

Int J Mol Sci
Dozio D, Caccia A, Dallavalle S, Beretta GL, Perego P, Artali R, Mazzini S, Princiotto S.   +7 more
europepmc   +1 more source

Determination of nucleotide-nucleotide and nucleotide-amino acid binding interactions from all-atom potential-of-mean-force calculations

Feito A, Pedraza E, Cuesta E, Castro A, Sanchez-Burgos I, Rey A, Collepardo-Guevara R, Tejedor AR, Espinosa JR.   +8 more
europepmc   +1 more source

Selective [9-¹⁵N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids. [PDF]

Chembiochem
Attionu SK, Dill R, Summers MF, Case DA, Marchant J, Dayie TK.   +5 more
europepmc   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source