Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]
, 2000 The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Faussner, Alexander +1 more
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Nucleotide discrimination with DNA immobilized in the MspA nanopore. [PDF]
PLoS ONE, 2011 Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction.
Elizabeth A Manrao +4 more
doaj +1 more source
Revisiting the Neutral Dynamics Derived Limiting Guanine-Cytosine Content Using the Human De Novo Point Mutation Data [PDF]
Meta Gene 31: 100994 (2022), 2020 We revisit the topic of human genome guanine-cytosine content under neutral evolution. For this study, the de novo mutation data within human is used to estimate mutational rate instead of using base substitution data between related species. We then define a new measure of mutation bias which separate the de novo mutation counts from the background ...
arxiv +1 more source
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
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Guanine nucleotide-dependent assembly of FtsZ into filaments [PDF]
Journal of Bacteriology, 1994 FtsZ is an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring. It contains the tubulin signature motif and is a GTP binding protein with a GTPase activity. Further comparison of FtsZ with eukaryotic tubulins revealed some additional sequence similarities, perhaps indicating a similar GTP ...
Amit Mukherjee, Joe Lutkenhaus
openaire +3 more sources
Dependence of nucleotide physical properties on their placement in codons and determinative degree
, 2007 Various physical properties such as dipole moment, heat of formation and energy of the most stable formation of nucleotides and bases were calculated by PM3 (modified neglect of diatomic overlap, parametric method number 3) and AM1 (Austin model 1 ...
Berezhnoy, A. Yu., Duplij, Steven
core +1 more source
The role of guanine nucleotides in protein biosynthesis
Biophysical Journal, 1978 It is not possible to select one competing substrate molecule over another one when the selection system is at equilibrium. Therefore, it is convenient to view all substrate selections as transport phenomena. The requirement for a displacement from equilibrium to effect a substrate selection can be met in different ways. One particularly convenient way
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Chasing Particularities of Guanine- and Cytosine-Rich DNA Strands
Molecules, 2020 By substitution of natural nucleotides by their abasic analogs (i.e., 1′,2′-dideoxyribose phosphate residue) at critically chosen positions within 27-bp DNA constructs originating from the first intron of N-myc gene, we hindered hybridization
Marko Trajkovski, Janez Plavec
doaj +1 more source
Purification of recombinant human and Drosophila septin hexamers for TIRF assays of actin-septin filament assembly [PDF]
Methods in Cell Biology, Elsevier, 2016, Septins, 136, pp.199, 2016 Septins are guanine nucleotide-binding proteins that are conserved from fungi to humans. Septins assemble into heterooligomeric complexes and higher-order structures with key roles in various cellular functions including cell migration and division. The mechanisms by which septins assemble and interact with other cytoskeletal elements like actin remain
arxiv +1 more source
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [PDF]
, 2010 The dynamin-related GTPase OPA1 is mutated in autosomal dominant optic atrophy (DOA) (Kjer type), an inherited neuropathy of the retinal ganglion cells.
Alexander +28 more
core +3 more sources