Results 71 to 80 of about 99,476 (367)

An Open Quantum Systems approach to proton tunnelling in DNA [PDF]

arXiv, 2021
One of the most important topics in molecular biology is the genetic stability of DNA. One threat to this stability is proton transfer along the hydrogen bonds of DNA that could lead to tautomerisation, hence creating point mutations. We present a theoretical analysis of the hydrogen bonds between the Guanine-Cytosine (G-C) nucleotide, which includes ...
arxiv  

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]

, 2013
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Wöhnert, Jens   +5 more
core   +1 more source

Origin of Guanine Nucleotides in Isolated Heart Mitochondria

Biochemical and Biophysical Research Communications, 1999
Presence of guanine nucleotide within the matrix of mitochondria is uncontested; the mechanism by which GTP takes up residence in the matrix is unknown. In this report, we demonstrate for the first time that direct transport of guanine nucleotide across the inner membrane of heart mitochondria is possible.
Ronald M. Smith, Ronald M. Smith, Edward E. McKee, Christina E. Ciaccio, Christina E. Ciaccio, Alice T. Bentley, Alice T. Bentley   +6 more
openaire   +3 more sources

Allosteric determinants in guanine nucleotide-binding proteins [PDF]

Proceedings of the National Academy of Sciences, 2003
Members of the G protein superfamily contain nucleotide-dependent switches that dictate the specificity of their interactions with binding partners. Using a sequence-based method termed statistical coupling analysis (SCA), we have attempted to identify the allosteric core of these proteins, the network of amino acid residues that couples ...
Alfred G. Gilman, Scott K. Gibson, Steve W. Lockless, Steve W. Lockless, Steve W. Lockless, Mark E. Hatley, Rama Ranganathan   +6 more
openaire   +3 more sources

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Essential role of GTP in epinephrine stimulation of human fat cell adenylate cyclase

Journal of Lipid Research, 1981
The activity of epinephrine-sensitive adenylate cyclase of human fat cell ghosts is markedly enhanced by the GTP analog 5'-guanylyl-imidodiphosphate (GMP-P(NH)P), but a similar effect of GTP itself has not been heretofore demonstrable.
M S Katz, J S Partilla, M A Piñeyro, R I Gregerman   +3 more
doaj  

Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years

Clinical Interventions in Aging, 2023
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B, Kusy K, Slominska EM, Ciekot-Sołtysiak M, Zieliński J   +4 more
doaj  

Functionalized Carbon Nanotube Electrodes for Controlled DNA Sequencing [PDF]

arXiv, 2020
In the last decade, solid state nanopores nanogaps have attracted significant interest in the rapid detection of DNA nucleotides. However, reducing the noise through the controlled translocating of the DNA nucleobases is a central issue for the developing nanogap nanopore based DNA sequencing to achieve single nucleobase resolution.
arxiv  

DNA nucleotide-specific modulation of \mu A transverse edge currents through a metallic graphene nanoribbon with a nanopore

, 2011
We propose two-terminal devices for DNA sequencing which consist of a metallic graphene nanoribbon with zigzag edges (ZGNR) and a nanopore in its interior through which the DNA molecule is translocated.
Areshkin D., Areshkin D. A., Brandbyge M., Branislav K. Nikolić, Brey L., Cai J., Cervantes-Sodi F., Fyta M., Garaj S., Geim A. K., Hasan M. Z., He Y., Healy K., Huang S., Jia X., Kamal K. Saha, Krems M., Kunstmann J., Lagerqvist J., Marija Drndić, Merchant C. A., Meunier V., Nelson T., Postma H. W. C., Prasongkit J., Rungger I., Rycerz A., Saha K. K., Saha K. K., Schadt E. E., Schneider G. F., Strange M., Tao C., Taylor J., Tsutsui M., Venkatesan B. M., Weeks C., Yazyev O. V., Zwolak M., Zârbo L. P.   +39 more
core   +1 more source