Results 21 to 30 of about 2,866 (140)

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland, A Hoebertz, A Surprenant, A Trautmann, A Verkhratsky, AN Drury, AV Gourine, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, B Hechler, B Johansson, B Vandewalle, BB Fredholm, BB Fredholm, BS Khakh, BS Khakh, C Giaume, C Ledent, C Ponnamperuma, CA Salvatore, CH Fiske, CI Seye, CJ Dixon, D Erlinge, DA Cockayne, E Ghanem, E Rapaport, EB Gonzales, EW Inscho, EW Sutherland, F Di Virgilio, F Di Virgilio, F Di Virgilio, F Lippman, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Clark, H Franke, H Woodward, H Zimmermann, HZ Ke, I Bar, IF Gow, IP Chessell, J Korcok, J Li, J Nilsson, JA Burgers, JA Sim, JE Wilson, JF Chen, JF Chen, JL Madara, JM Armstrong, JM Sanz, JT Neary, K Inoue, K Inoue, K Inoue, K Lohmann, K Mulryan, K Wirkner, K Yamamoto, KA Moore, L Gimenez-Llort, L Li, M Horckmans, M Naassila, M Ryten, M Shabbir, M Shabbir, M Shabbir, M Sugioka, M Tsuda, MJ Bours, MJ Ludlow, MM Waldrop, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Meyer, MW Grol, MW Verghese, MY Avila, N Lenain, N Panupinthu, N White, N White, N White, PB Conley, R Brown, R Janssens, RA North, RA North, RJ Cerniway, S Kirischuk, S Kirischuk, S Pochet, S Ryzhov, SD Ohlendorff, SJ Fountain, SJ Fountain, SL Tilley, T Kawate, TE Finger, U Groschel-Stewart, U Groschel-Stewart, UK Hanisch, V Ralevic, V Ralevic, V Souslova, VL Cressman, X Bian, X Hua, Y Guo, Y Pankratov, Y Pankratov, Y Pankratov, Y Pankratov, YD Bogdanov, Z Xiang, Z Zhao   +139 more
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Muscarinic acetylcholine receptor‐stimulated binding of guanosine 5′‐O‐(3‐thiotriphosphate) to guanine‐nucleotide‐binding proteins in cardiac membranes [PDF]

European Journal of Biochemistry, 1989
Receptor‐regulated binding of the labeled GTP analog, guanosine 5′‐O‐(3‐thiotriphosphate) ([35S]GTP[S]), to guanine‐nucleotide‐binding proteins (G‐proteins) was studied in porcine atrial membranes enriched in muscarinic acetylcholine (mACh) receptors. Binding of [35S]GTP[S] to the membranes was not or only slightly affected by the cholinergic agonist ...
G, Hilf, P, Gierschik, K H, Jakobs
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G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular sensory epithelia of the rat are insensitive to cholera and pertussis toxins [PDF]

, 1994
In the cochlear (CSE) and vestibular sensory epithelia (VSE), phosphoinositides are hydrolyzed in response to stimulation of phospholipase C (PLC) by cholinergic muscarinic and purinergic P2y agonists. Such receptor-mediated activation of PLC is expected
Berridge, Bradford, Canlon, Cockcroft, Cockcroft, Dean, Dubyak, Dunlop, Fischer, Fishman, Fleming, Gill, Gill, Gilmann, Guiramand, Haggblad, Helper, Hepler, Housley, Kakehata, Kakehata, Katada, Katada, Kaziro, Laemmli, Litosch, Marc, Masters, Mei, Nanoff, Niedzielski, Niedzielski, Niedzielski, Ogawa, Okajima, Sasaguri, Schnefel, Sternweis, Sternweis, Tachibana, Yamada   +40 more
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Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.

Journal of Biological Chemistry, 1990
L'ajout de guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) à des fibroblastes pulmonaires intacts de hamster chinois (CCL39) dépolarisés par des concentrations élevées de K+ entraîne l'activation de la phospholipase C spécifique du phosphoinositide (PLC) (à des concentrations de GTP gamma S supérieures à 0,1 mM), l'inhibition de l'adénylate cyclase ...
S Paris, Jacques Pouysségur
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GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity. [PDF]

, 2017
Positive modulation of the GABAB receptor (GABABR) represents a potentially useful therapeutic approach for the treatment of nicotine addiction. The positive allosteric modulators (PAMs) of GABABR GS39783 and BHF177 enhance GABA-stimulated [35S]GTP γS ...
Cameron, Michael, de Lourdes Ladino, Maria, Finn, MG, Griffin, Patrick R, Kaczanowska, Kasia, Li, Xia, Markou, Athina, McDonald, Patricia, Sturchler, Emmanuel   +8 more
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Contribution of G Protein Activation to Fluoride Stimulation of Phosphoinositide Hydrolysis in Human Neuroblastoma Cells [PDF]

, 1993
To examine the possibility that NaF enhances phosphoinositide-specific phospholipase C (PIC) activity in neural tissues by a mechanism independent of a guanine nucleotide binding protein (G p ), we have evaluated the contribution of G p activation to NaF-
Fisher, Stephen K., Kunkle, Christopher, McEwen, Edward L., Slowiejko, Diana M., Thompson, Angela K.   +4 more
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Involvement of the transmembrane protein p23 in biosynthetic protein transport [PDF]

, 1997
The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Alcalde, Allan, Aniento, Aniento, Ansorge, Belden, Bergmann, Blum, Bomsel, Celis, Church, Cole, Cosson, Dupree, Elrod-Erickson, Emans, Evan, Fiedler, Griffiths, Griffiths, Griffiths, Griffiths, Gruenberg, Gruenberg, Gruenberg, Hauri, Jackson, Klausner, Kozak, Kreis, Kreis, Kreis, Laemmli, Letourneur, Letourneur, Lewis, Lippincott-Schwartz, Lotti, Lowe, Ludwig, Luzio, Nakamura, Nielsen, Nilsson, Nilsson, Oprins, Orci, Orci, Palade, Pelham, Pepperkok, Pevsner, Pryer, Quinn, Rambourg, Rios, Rogalski, Rothman, Saraste, Saraste, Scheel, Schimmöller, Schweizer, Schweizer, Serafini, Sohn, Stamnes, Subramaniam, Sönnichsen, Tang, Tang, Tisdale, Trowbridge, Wada, Warren   +74 more
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The Calcium Transient in Sea Urchin Eggs during Fertilization Requires the Production of Inositol 1,4,5-Trisphosphate [PDF]

, 1998
The production of inositol 1,4,5-trisphosphate (InsP3) has been reported to mediate the transient rise in intracellular Ca2+activity ([Ca2+]i) in sea urchin eggs during fertilization.
Lee, Shyh-Jye, Shen, Sheldon S.
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Guanosine 5´-O-(3-Thiotriphosphate) and Cations Regulate Melatonin Receptors, and Melatonin Inhibits Cyclic AMP Production in the Spinal Cord

Neurosignals, 1997
Effects of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and cations on 2-[125I]iodomelatonin binding were investigated in membrane preparations of the chicken spinal cord. At concentrations of 10 and 50 mumol/l, GTP gamma S dose-dependently increased (p < 0.05) the equilibrium dissociation constant (Kd) and depressed (p < 0.05) the maximum number ...
Q, Wan, M X, Liao, C S, Pang, S F, Pang, G M, Brown   +4 more
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Kinetics and activation of phospholipase C by P2Y purinergic agonists and guanine nucleotides [PDF]

, 1989
Membranes prepared from [3H]inositol-labeled turkey erythrocytes express a phospholipase C that is markedly stimulated by stable analogs of GTP (Harden, T. K., Stephens, L., Hawkins, P. T., and Downes, C. P. (1987) J. Biol. Chem. 262, 9057-9061).
Boyer, JL, Downes, CP, Harden, T
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