Results 111 to 120 of about 30,288 (231)

Kinetic analysis of the activation of transducin by photoexcited rhodopsin. Influence of the lateral diffusion of transducin and competition of guanosine diphosphate and guanosine triphosphate for the nucleotide site

, 1992
The activation of transducin (T) by photoexcited rhodopsin (R*) is kinetically dissected within the framework of Michaelis-Menten enzymology, taking transducin as substrate of the enzyme R*. The light scattering "release" signal (Vuong, T.M., M.
Bruckert, F., Chabre, M., Vuong, T.M.
core   +1 more source

Advances in Research on the Anti‐Tuberculosis Effects of Active Components in Chinese Herbal Medicine

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
This review summarizes how active constituents derived from Chinese herbal medicine exert anti‐tuberculosis (TB) effects via immunomodulation, direct inhibition of pathogens, and antioxidant activity. This synergistic, multi‐pathway mechanism highlights their potential as promising therapeutic candidates and adjunctive treatments against drug‐resistant
Qianqian Zhang, Siqi Lin, Juan Liu, Huani Wu, Xiaodan Lin, Jiawen He, Qiaoyu Yang, Jiang Pi, Fen Yang   +8 more
wiley   +1 more source

Rate studies of polysaccharide biosynthesis from guanosine diphosphate α-d-glucose and guanosine diphosphate α-d-mannose [PDF]

Biochemical Journal, 1971
With enzyme preparations from Phaseolus aureus seedlings, the initial rate of 14C-labelled polysaccharide formation from GDP-α-d-[14C]glucose is not increased by additions of GDP-α-d-mannose. However, final incorporation is increased by addition of GDP-α-d-mannose, since the total reaction-time is extended. In contrast, the initial rate of 14C-labelled
openaire   +2 more sources

Dynamic disorder is crucial for mitochondrial protein import

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The import of proteins into mitochondria poses fundamental mechanistic challenges: aggregation‐prone precursor proteins must be maintained in aqueous compartments and threaded through narrow pores without becoming stuck or mislocalized. Recent evidence from mitochondrial protein import studies and other chaperone systems underscores the ...
Jakob Schneider, Undina Guillerm, Caroline Simões Pereira, Paul Schanda   +3 more
wiley   +1 more source

Detailed Structure of the H₂PO₄^––Guanosine Diphosphate Intermediate in Ras-GAP Decoded from FTIR Experiments by Biomolecular Simulations

, 2016
Essential biochemical processes such as signal transduction, energy conversion, or substrate conversion depend on transient ligand binding. Thus, identifying the detailed structure and transient positioning of small ligands, and their stabilization by ...
Qiang Cui (214006), Fei Xia (256985), Klaus Gerwert (1564180), Till Rudack (2013829), Carsten Kötting (1564174)   +4 more
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Hydrogen bonding, spectroscopic (FT-IR and FT-Raman), UV−Vis, and Mulliken charge analysis of Guanosine-5′ -Diphosphate: insight from DFT and molecular docking

Bibechana
Hybrid functional B3LYP has been used for quantum chemical calculation of Guanosine-5′ -Diphosphate (GDP) from DFT approach. The intra-molecular hydrogen bonding in the title molecule was rendered from Quantum theory of atoms in molecule (QTAIM).
Manoj Kumar Chaudhary, Tarun Chaudhary, Bhawani Datt Joshi, Gulab Singh Verma, Rajesh Kumar Shukla, Tirth Raj Paneru   +5 more
doaj   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides

, 1988
NADPH-oxidase-catalyzed superoxide (O2-) formation in membranes of HL-60 leukemic cells was activated by arachidonic acid in the presence of Mg2+ and HL-60 cytosol.
Rosenthal, W., Wieland, T., Schultz, G., Jakobs, K.H., Seifert, R., Seifert, Roland, Schultz, Günter, Jakobs, K. H., Gierschick, P.   +8 more
core   +1 more source

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
wiley   +1 more source

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp), guanosine 5'-diphosphate 3'-monophosphate (ppGp) and antibiotic production in Streptomyces clavuligerus

Streptomyces clavuligerus was grown in nutrient-limited defined media in laboratory scale fermenters using continuous and batch culture methods. Cephamycin C was produced in all fermentations.
Jones, Christine
core