Results 111 to 120 of about 66,472 (220)

GUANOSINE BASED NANODEVICES

, 2009
In this talk I will report on nanotechnological strategies to fabricate electronic devices based on guanosines and guanosine-oligothiophenes complexes.
SPADA, GIAN PIERO, G. Maruccio, R. Rinaldi, V. Arima, R. Cingolani   +4 more
core   +1 more source

Detection and characterisation of NAD(P)H-diaphorase activity in Dictyostelium discoideum cells (Protozoa)

European Journal of Histochemistry, 2012
In Dictyostelium discoideum (D. discoideum), compounds generating nitric oxide (NO) inhibit its aggregation and differentiation without altering cyclic guanosine monophosphate (cGMP) production.
A. Amaroli, M.G. Chessa
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Covalent Guanosine Mimetic Inhibitors of G12C KRAS

, 2016
Ras proteins are members of a large family of GTPase enzymes that are commonly mutated in cancer where they act as dominant oncogenes. We previously developed an irreversible guanosine-derived inhibitor, SML-8-73-1, of mutant G12C RAS that forms a ...
Taebo Sim (806344), John Hunter (1349355), Jia Lu (181094), Hwan Geun Choi (750017), Lianbo Li (3545675), Sudershan Gondi (3545678), Yuan Xiong (40206), Nathanael S. Gray (150685), Sang Min Lim (1484440), David Scott (152448), Kenneth D. Westover (1349343), Anuj Manandhar (3545672)   +11 more
core   +1 more source

Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling [PDF]

, 2014
International audienceDynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for membrane-remodeling events. We found that knockdown of nucleoside diphosphate kinases (NDPKs) NM23-H1/H2, which produce GTP through ...
Boissan, M., T. Lagache, Griparic, Lorena, Romao, Maryse, M. Romao, Sauvonnet, N., I. Lascu, van der Bliek, Alexander M, Raposo, G., Romao, M., G. Montagnac, Montagnac, G., S. Polo, Raposo, Graça, A. Roux, van Der Bliek, Alexander, Desbourdes, Céline, Polo, S., Desbourdes, C., Schlattner, Uwe, M. Boissan, Chavrier, Philippe, Shen, Qinfang, Lagache, Thibault, C. Desbourdes, Sauvonnet, Nathalie, Roux, Aurélien, P. Chavrier, Shen, Q., Polo, Simona, U. Schlattner, A. M. Van Der Bliek, G. Raposo, J. Guitton, van der Bliek, A. M., Chavrier, P., L. Griparic, Q. Shen, N. Sauvonnet, Boissan, Mathieu, Lacombe, M.-L., Lacombe, Marie-Lise, Guitton, J., Lagache, T., Lascu, Ioan, Lascu, I., Montagnac, Guillaume, Guitton, Jérome, M. Lacombe   +48 more
core   +1 more source

Rate studies of polysaccharide biosynthesis from guanosine diphosphate α-d-glucose and guanosine diphosphate α-d-mannose [PDF]

Biochemical Journal, 1971
With enzyme preparations from Phaseolus aureus seedlings, the initial rate of 14C-labelled polysaccharide formation from GDP-α-d-[14C]glucose is not increased by additions of GDP-α-d-mannose. However, final incorporation is increased by addition of GDP-α-d-mannose, since the total reaction-time is extended. In contrast, the initial rate of 14C-labelled
openaire   +2 more sources

Guanosine-based amphiphiles: synthesis, biophysical characterization and biological activity

, 2011
A mini-library of amphiphllic guanosine derivatives has been prepared starting from a unique, fully base-protected precursor, and analyzed in their G-quadruplex formation ability, ion transport properties and antiproliferative ...
DE NAPOLI, LORENZO, MONTESARCHIO, DANIELA, P. Tecilla, DI PASCALE, ANTONIO, IRACE, CARLO, M. Boccalon, SIMEONE, LUCA   +6 more
core  

Hydrogen bonding, spectroscopic (FT-IR and FT-Raman), UV−Vis, and Mulliken charge analysis of Guanosine-5′ -Diphosphate: insight from DFT and molecular docking

Bibechana
Hybrid functional B3LYP has been used for quantum chemical calculation of Guanosine-5′ -Diphosphate (GDP) from DFT approach. The intra-molecular hydrogen bonding in the title molecule was rendered from Quantum theory of atoms in molecule (QTAIM).
Manoj Kumar Chaudhary, Tarun Chaudhary, Bhawani Datt Joshi, Gulab Singh Verma, Rajesh Kumar Shukla, Tirth Raj Paneru   +5 more
doaj   +1 more source

Envolvimento dos receptores NMDA e da via L-arginina-óxido nítrico-GMPc no efeito tipo-antidepressivo da guanosina [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.A guanosina é um nucleosídeo endógeno que modula a captação de glutamato pelos astrócitos, controlando os níveis ...
Bettio, Luis Eduardo Beltrão
core  

Borrelia Burgdorferi Rel Is Responsible for Generation of Guanosine-3′-Diphosphate-5′-Triphosphate and Growth Control

, 2005
The global transcriptional regulator (p)ppGpp (guanosine-3\u27-diphosphate-5\u27-triphosphate and guanosine-3\u27,5\u27-bisphosphate, collectively) produced by the relA and spoT genes in Escherichia coli allows bacteria to adapt to different ...
Bryksin, Anton V., Bugrysheva, Julia, Godfrey, Henry P., Cabello, Felipe C.   +3 more
core   +1 more source