Results 31 to 40 of about 1,579 (116)
Microbiology Spectrum, 2023 The stringent response enables bacteria to survive nutrient starvation, antibiotic challenge, and other threats to cellular survival. Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp ...
Miao Wang +3 more
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Forming and waking dormant cells: The ppGpp ribosome dimerization persister model
Biofilm, 2020 Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence.
Thomas K. Wood, Sooyeon Song
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The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. [PDF]
PLoS Pathogens, 2015 As the Lyme disease bacterium Borrelia burgdorferi traverses its enzootic cycle, alternating between a tick vector and a vertebrate host, the spirochete must adapt and persist in the tick midgut under prolonged nutrient stress between blood meals.
Dan Drecktrah +5 more
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Homology Model of a Catalytically Competent Bifunctional Rel Protein
Frontiers in Molecular Biosciences, 2021 Bacteria have developed different bet hedging strategies to survive hostile environments and stressful conditions with persistency being maybe the most elegant yet still poorly understood one. Persisters’ temporary tolerance to antibiotic treatment hints
Monica Civera, Sara Sattin
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Frontiers in Cellular and Infection Microbiology, 2022 Antimicrobial resistance (AMR) in bacteria is an important global health problem affecting humans, animals, and the environment. AMR is considered as one of the major components in the “global one health”.
Thandavarayan Ramamurthy +6 more
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New Phytologist, Volume 239, Issue 1, Page 222-239, July 2023., 2023 Summary To infect plants, pathogenic fungi secrete small proteins called effectors. Here, we describe the catalytic activity and potential virulence function of the Nudix hydrolase effector AvrM14 from the flax rust fungus (Melampsora lini). We completed extensive in vitro assays to characterise the enzymatic activity of the AvrM14 effector ...
Carl L. McCombe +11 more
wiley +1 more source
c‐di‐GMP regulates activity of the PlzA RNA chaperone from the Lyme disease spirochete
Molecular Microbiology, Volume 119, Issue 6, Page 711-727, June 2023., 2023 PlzA is a c‐di‐GMP‐binding protein crucial for adaptation and survival of Borrelia burgdorferi, the etiologic agent of Lyme disease, as it cycles between its vertebrate host and tick vector. We report that PlzA has RNA chaperone activity that is regulated by c‐di‐GMP.
Taylor Van Gundy +10 more
wiley +1 more source
New Phytologist, Volume 237, Issue 4, Page 1086-1099, February 2023., 2023 Summary The nucleotides guanosine tetraphosphate and guanosine pentaphosphate (together (p)ppGpp) are found in a wide range of prokaryotic and eukaryotic organisms where they are associated with stress signalling. In this review, we will discuss recent research highlighting the role of (p)ppGpp signalling as a conserved regulator of photosynthetic ...
Marwa Mehrez, Shanna Romand, Ben Field
wiley +1 more source
ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus
Cell Reports, 2017 The bacterial and plant stringent response involves production of the signaling molecules guanosine tetraphosphate and guanosine pentaphosphate ((p)ppGpp), leading to global reorganization of gene expression.
Anna M. Puszynska, Erin K. O’Shea
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Microbiology Spectrum, 2023 Persistent methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections represent a serious public health threat. We recently demonstrated that the presence of a novel prophage ϕSA169 was associated with vancomycin (VAN) treatment failure ...
Yi Li +9 more
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