Results 41 to 50 of about 1,579 (116)
LD‐transpeptidases: the great unknown among the peptidoglycan cross‐linkers
The FEBS Journal, Volume 289, Issue 16, Page 4718-4730, August 2022., 2022 Peptidoglycan cross‐linking enzymes LD‐transpeptidases (LDTs) have kept an aura of mystery for a long time. However, a number of recent reports have linked the activity of LDTs to cell wall adaptation to stress including β‐lactam antibiotics, outer membrane stability, and toxin delivery.
Alena Aliashkevich, Felipe Cava
wiley +1 more source
Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes**
Angewandte Chemie, Volume 134, Issue 22, May 23, 2022., 2022 Molecular fishing: A family of trifunctional photoaffinity capture compounds enables the identification of putative Magic Spot Nucleotide receptors by a chemoproteomics approach. The resulting datasets cover several bacterial species, correlate with distinct nucleotide phosphorylation patterns and represent high‐value starting points for future ...
Thomas M. Haas +12 more
wiley +1 more source
Bio-Protocol, 2016 The stringent response in bacteria is a stress response that is mediated by the signaling molecules guanosine tetraphosphate and pentaphosphate [(p)ppGpp], alarmones that are also directly related to virulence. Therefore, determination of (p)ppGpp levels
Smitha Sivapragasam, Anne Grove
doaj +1 more source
Robotic-Assisted Capture-Systematic Evolution of Ligands by Exponential Enrichment of RNA Aptamers Binding to Small Molecules. [PDF]
ChembiochemThis study demonstrates the rapid selection of RNA aptamers that can target various small molecules through a newly established automated capture‐systematic evolution of ligands by exponential enrichment technique. Throughout the study, this method is applied to aptamer selection for several small molecules, resulting in aptamers that bind with high ...
Legen T, Mayer G.
europepmc +2 more sources
Synthesis of guanosine tetra- and pentaphosphates by the obligately anaerobic bacterium Bacteroides thetaiotaomicron in response to molecular oxygen [PDF]
Journal of Bacteriology, 1979 Guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate 3'-diphosphate (pppGpp) were detected in formic acid extracts of air-exposed culutres of Bacteroides thetaiotaomicron. The identification of ppGpp and pppGpp in B. thetaiotaomicron was based on the following results: (i) cochromatography of 32P-labeled hyperphosphorylated ...
T L, Glass +3 more
openaire +2 more sources
SpoT Induces Intracellular
mBio, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Liam F. Fitzsimmons +8 more
doaj +1 more source
Studies on the Control of Development. Accumulation of Guanosine Tetraphosphate and Pentaphosphate in Response to Inhibition of Protein Synthesis in Bacillus subtilis [PDF]
European Journal of Biochemistry, 1975 Bacillus subtilis cells accumulate unusual phosphorylated substances at the end of logarithmic growth in a semi-synthetic medium. Two of these substances are guanosine 3'(2')-diphosphate 5'-diphosphate (ppGpp) and guanosine 3'(2')-diphosphate 5'-triohosphate (pppGpp) which, in contrast to amino-acid-starved Escherichia coli cells, are not degraded in ...
H J, Rhaese, H, Dichtelmüller, R, Grade
openaire +2 more sources
BMC Genomics, 2020 Background The nucleotide second messengers, i.e., guanosine tetraphosphate and pentaphosphate [collectively referred to as (p) ppGpp], trigger the stringent response under nutrient starvation conditions and play an essential role in virulence in the ...
Ho-wen Yang +4 more
doaj +1 more source
Life, 2014 Second messengers are intracellular substances regulated by specific external stimuli globally known as first messengers. Cells rely on second messengers to generate rapid responses to environmental changes and the importance of their roles is becoming ...
Marco Agostoni, Beronda L. Montgomery
doaj +1 more source
BMC Genomics, 2020 Background Pseudomonas syringae is an important plant pathogen, which could adapt many different environmental conditions. Under the nutrient-limited and other stress conditions, P.
Jun Liu +6 more
doaj +1 more source