Results 51 to 60 of about 6,159 (212)

ppGpp accumulation reduces the expression of the global nitrogen homeostasis-modulating NtcA regulon by affecting 2-oxoglutarate levels

open access: yesCommunications Biology, 2023
The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the ...
Ryota Hidese   +8 more
doaj   +1 more source

Effects of Guanosine Tetraphosphate, Guanosine Pentaphosphate, and β-γ Methylenyl-Guanosine Pentaphosphate on Gene Expression of Escherichia coli In Vitro [PDF]

open access: yesProceedings of the National Academy of Sciences, 1974
The effects of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), both produced by E. coli , were measured on the activities of several genes in a cell-free system. Gene activity is measured as gene-directed synthesis of biochemically competent protein or transfer RNA.
H L, Yang   +4 more
openaire   +2 more sources

An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control

open access: yesnpj Systems Biology and Applications, 2022
Growth and environmental responses are essential for living organisms to survive and adapt to constantly changing environments. In order to simulate new conditions and capture dynamic responses to environmental shifts in a developing whole-cell model of ...
Travis A. Ahn-Horst   +4 more
doaj   +1 more source

How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016) [PDF]

open access: yes, 2017
Procedures are proposed for the naming of individual atoms, P, O, F, N, and S in phosphate esters, amidates, thiophosphates, polyphosphates, their mimics, and analogues of transition states for enzyme-catalyzed phosphoryl transfer reactions.
Blackburn, G.M.   +6 more
core   +4 more sources

Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]

open access: yes, 2017
Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma   +6 more
core   +2 more sources

Control of rRNA and tRNA syntheses in Escherichia coli by guanosine tetraphosphate [PDF]

open access: yesJournal of Bacteriology, 1982
The expression of stable RNA (rRNA and tRNA) genes and the concentration of guanosine tetraphosphate (ppGpp) were measured in an isogenic pair of relA+ and relA derivatives of Escherichia coli B/r. The cells were either growing exponentially at different rates or subject to amino acid starvation when they were measured.
J, Ryals, R, Little, H, Bremer
openaire   +2 more sources

Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically

open access: yesEBioMedicine, 2016
Cutaneous abscess infections are difficult to treat with current therapies and alternatives to conventional antibiotics are needed. Understanding the regulatory mechanisms that govern abscess pathology should reveal therapeutic interventions for these ...
Sarah C. Mansour   +7 more
doaj   +1 more source

relA enhances the adherence of enteropathogenic Escherichia coli. [PDF]

open access: yesPLoS ONE, 2014
Enteropathogenic Escherichia coli (EPEC) is a known causative agent of diarrhea in children. In the process of colonization of the small intestine, EPEC synthesizes two types of adhesins, the bundle-forming pilus (BFP) and intimin.
Beny Spira   +2 more
doaj   +1 more source

Identification of the BolA Protein Reveals a Novel Virulence Factor in K. pneumoniae That Contributes to Survival in Host

open access: yesMicrobiology Spectrum, 2022
BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence.
Feiyang Zhang   +8 more
doaj   +1 more source

Synthesis of (di)nucleoside polyphosphates by the ubiquitin activating enzyme E1 [PDF]

open access: yes, 2013
Open Access.Previous work from this laboratory had shown that ligases may catalyze the synthesis of (di)nucleoside polyphosphates. Here, we show that one of the enzymes of the proteasome system (E1 or the ubiquitin (Ub) activating enzyme, EC 6.3.2.19 ...
Diego, Anabel de   +3 more
core   +2 more sources

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