Results 71 to 80 of about 6,159 (212)

Small molecule control of virulence gene expression in Francisella tularensis. [PDF]

PLoS Pathogens, 2009
In Francisella tularensis, the SspA protein family members MglA and SspA form a complex that associates with RNA polymerase (RNAP) to positively control the expression of virulence genes critical for the intramacrophage growth and survival of the ...
James C Charity, Leeann T Blalock, Michelle M Costante-Hamm, Dennis L Kasper, Simon L Dove   +4 more
doaj   +1 more source

Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen [PDF]

, 2017
The Bartonella gene transfer agent (BaGTA) is an archetypical example for domestication of a phage-derived element to permit high-frequency genetic exchange in bacterial populations.
Christen, Beat, Christen, Matthias, Dehio, Christoph, Harms, Alexander, Körner, Jonas, Québatte, Maxime   +5 more
core   +1 more source

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah, Munthar Kadhim‐Abosaoda, Hayjaa Mohaisen‐Mousa, S. Renuka Jyothi, Priya Priyadarshini‐Nayak, J. Bethanney Janney, Gurjant Singh, Ashish Singh‐Chauhan, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

The constancy of global regulation across a species: the concentrations of ppGpp and RpoS are strain-specific in Escherichia coli. [PDF]

, 2011
BACKGROUND: Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS) are potentially subject to variability across the species Escherichia coli.
Betteridge, T, Ferenci, T, Galbiati, HF, Phan, K, Spira, B   +4 more
core   +3 more sources

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
wiley   +1 more source

Induction of the Stringent Response Underlies the Antimicrobial Action of Aliphatic Isothiocyanates

Frontiers in Microbiology, 2021
Bacterial resistance to known antibiotics comprises a serious threat to public health. Propagation of multidrug-resistant pathogenic strains is a reason for undertaking a search for new therapeutic strategies, based on newly developed chemical compounds ...
Dariusz Nowicki, Klaudyna Krause, Patrycja Szamborska, Adrianna Żukowska, Grzegorz M. Cech, Agnieszka Szalewska-Pałasz   +5 more
doaj   +1 more source

Purification, crystallization and X-ray crystallographic analysis of a putative exopolyphosphatase from Zymomonas mobilis [PDF]

, 2016
Exopolyphosphatase (PPX) enzymes degrade inorganic polyphosphate (poly-P), which is essential for the survival of microbial cells in response to external stresses.
Bartlam, M, Guo, E, Qian, L, Tang, NY, Watt, RM, Zhang, A   +5 more
core   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

The primary transcriptome of Salmonella enterica Serovar Typhimurium and its dependence on ppGpp during late stationary phase. [PDF]

PLoS ONE, 2014
We have used differential RNA-seq (dRNA-seq) to characterise the transcriptomic architecture of S. Typhimurium SL1344, and its dependence on the bacterial alarmone, guanosine tetraphosphate (ppGpp) during late stationary phase, (LSP).
Vinoy K Ramachandran, Neil Shearer, Arthur Thompson   +2 more
doaj   +1 more source

Cross-talk between two nucleotide-signaling pathways in Staphylococcus aureus. [PDF]

, 2014
Nucleotide-signaling pathways are found in all kingdoms of life and are utilized to coordinate a rapid response to external stimuli. The stringent response alarmones guanosine tetra- (ppGpp) and pentaphosphate (pppGpp) control a global response allowing ...
Alexandra R. Willis, An, Angelika Gründling, Bae, Bai, Bai, Battesti, Boles, Cashel, Cashel, Charpentier, Corrigan, Corrigan, Corrigan, Cosgrove, Dalebroux, Fiil, Fong, French, Gao, Gao, Geiger, Geiger, Geiger, Gentry, Glass, Griffiths, Gründling, Hanahan, Herbert, Horsburgh, Knutsson Jenvert, Lee, Lemos, Lisa Bowman, Lu, Lund, Luo, L̸eski, Maisonneuve, McDonough, Mehne, Memmi, Miller, Mwangi, Nagarajan, Nanamiya, Nelson, Nguyen, Ochi, Potrykus, Pozzi, Rallu, Rao, Rebecca M. Corrigan, Roelofs, Rudin, Römling, Smith, Song, Sureka, Thomaides, Volkhard Kaever, Webb, Witney, Witte, Woodward   +66 more
core   +1 more source