Results 71 to 80 of about 852,730 (306)

Microbiota and chronic inflammatory arthritis. an interwoven link [PDF]

, 2016
Background: Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host's health and disease.
D'Amelio, Raffaele, Laganà, Bruno, Manuela Rosado, M, Picchianti Diamanti, Andrea   +3 more
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Acidification increases abundances of Vibrionales and Planctomycetia associated to a seaweed-grazer system: potential consequences for disease and prey digestion efficiency [PDF]

, 2018
Ocean acidification significantly affects marine organisms in several ways, with complex interactions. Seaweeds might benefit from rising CO2 through increased photosynthesis and carbon acquisition, with subsequent higher growth rates.
Aires, Aires, Aires, Asnaghi, Asplund, Avelin Mary, Barbieri, Barneah, Beleneva, Bengtsson, Berg, Bodelier, Bodenhausen, Bourne, Bourne, Branch, Briggs, Burgess, Burke, Burke, Caporaso, Cardoso, Case, Cayrou, Chao, Chojnacka, Church, Clarke, Clarke, Cornwall, Cottrell, Currie, Davis, Devine, Dimitrieva, Dittmer, Dudek, Eberl, Edgar, Egan, Fabry, Fenchel, Fraune, Frey, Fuerst, Gachon, Garrity, Glöckner, Goffredi, Greiman, Gutow, Hacquard, Harley, Hassenrück, Head, Hentschel, Hollants, Holmstrom, Holmström, Hong, Huggett, Kerfahi, King, Kirchman, Koch, Kooperman, Kroeker, Lachnit, Lage, Lane, Liu, Longford, Mackie, Maki, Marzinelli, Matsuo, Matsuo, Mattila, McDonald, Mensch, Meron, Meusnier, Meziti, Moisander, Morrow, Nedashkovskaya, Olischläger, Parris, Patel, Perlman, Poore, Porzio, Sawabe, Schulze, Shah, Shnit-Orland, Simon, Singh, Singh, Song, Staufenberger, Sullam, Sunagawa, Suzuki, Taylor, Thomas, Thomas, Thurber, Tietjen, Tujula, Urabe, Van De Waal, Vezzulli, Vieira, Wang, Wang, Wang, Webster, Witt, Yuksel, Zimmer, Zimmer, Zimmer   +122 more
core   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Gut microbiota and female health

World Journal of Gastroenterology
The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast ...
Wang, Meng-Yao, Sang, Li-Xuan, Sun, Si-Yu   +2 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues

Biomolecules, 2020
Intact intestinal barrier function is essential for maintaining intestinal homeostasis. A dysfunctional intestinal barrier can lead to local and systemic inflammation through translocation of luminal antigens and has been associated with a range of ...
Mathias W. Tabat, Tatiana M. Marques, Malin Markgren, Liza Löfvendahl, Robert J. Brummer, Rebecca Wall   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The gut microbiome: Relationships with disease and opportunities for therapy. [PDF]

, 2019
Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age.
Durack, Juliana, Lynch, Susan V
core