Results 111 to 120 of about 24,574 (211)

Identificación de polimorfismos en el gen gyrA de Pseudomonas aeruginosa de pacientes con fibrosis quística y otras patologías en la ciudad de Cartagena (Colombia) [PDF]

, 2011
La fibrosis quística (FQ) es una enfermedad genética debida a mutaciones en el gen CFTR que codifica un canal de cloruro. Los pacientes con FQ expresan un canal no funcional en la membrana de las células epiteliales, y son susceptibles a infecciones ...
Caldera Díaz, Oscar Javier
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In vitro Quinolones Susceptibility Analysis of Chinese Mycoplasma bovis Isolates and their Phylogenetic Scenarios based upon QRDRs of DNA Topoisomerases Revealing a Unique Transition in ParC [PDF]

Pakistan Veterinary Journal, 2013
Mycoplasma bovis can cause different systemic problems in cattle, and recently has been resulted in huge economic losses in China. In vitro susceptibilities of 26 twice sub-cultured Chinese M.
Riaz Mustafa1,2,3, Jingjing Qi1,2, Xiaoliang Ba1,2, Yingyu Chen1,4, Changmin Hu1,2, Xiaole Liu1,2, Lingling Tu5, Qingjie Peng5, Huanchun Chen1,2 and Aizhen Guo1,2*
doaj  

Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis

, 2016
International audienceOBJECTIVES:Resistance to fluoroquinolones (FQs) in Mycobacterium tuberculosis (Mtb) is mainly due to mutations in DNA gyrase (GyrA2B2), with the most common substitutions located at positions 90 and 94 in GyrA. Two clinical MDR Mtb (
Bouige, Aurélie, Ferrand, Hélène, Aubry, Alexandra, Pantel, Alix, Matrat, Stéphanie, Mayer, Claudine, Sougakoff, Wladimir, Petrella, Stéphanie, Veziris, Nicolas   +8 more
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Worldwide comparison of Salmonella Enteritidis genomes with and without the gyrA codon substitution D87Y

Salmonella enterica serovar Enteritidis (S. Enteritidis) with decreased susceptibility to ciprofloxacin (DSC) has emerged in the United States, driven by NCBI SNP Cluster PDS000065758 (denoted SE65758) strains with GyrA(D87Y).
Kaitlin A. Tagg, David J. Bradshaw II, Hattie E. Webb, Shawn M.D. Be, Bradley L. Bearson   +4 more
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Effect of QRDR Mutations on Ciprofloxacin Resistance in Clinical Isolates of Pseudomonas aeruginosa

Journal of Ardabil University of Medical Sciences, 2016
Background & objectives: Fluoroquinolones have important role in treatment of P. aeruginosa infections. The main mechanism of fluoroquinolones resistance in P. aeruginosa is mutations in the quinolone-resistance-determining region (QRDR) of gyrA and parC
Roqiyeh Nouri, Mohammad Ahangarzadeh Rezaee, Alka Hasani, Mohammad Aghazadeh, Mohammad Asgharzadeh, Morteza Ghojazadeh   +5 more
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Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: Functional analysis of gyrA mutation at position 74

, 2011
A PCR-sequencing assay was evaluated for direct detection of mutations in the quinolone resistance-determining region (QRDR) of gyrase A (gyrA) gene in fluoroquinolone-resistant Mycobacterium tuberculosis in respiratory specimens.
Yam, WC, Cheng, VCC, Lau, RWT, Tsui, SKW, Wing-Cheong Yam, Chen, X, Lau, TCK, Kwok-Yung Yuen, Vincent C. C. Cheng, Richard Y. T. Kao, Ho, PL, Kao, RYT, Yew, WW, Yuen, KY, Terrence C. K. Lau, Wing-Wai Yew, Xinchun Chen, Ricky W. T. Lau, Pak-Leung Ho, Stephen K. W. Tsui   +19 more
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Multiplex PCR for single nucleotide polymorphism (SNP) of fluoroquinolones (gyrA and parC) on 1.5% agarose gels.

, 2019
Lane 1: gyrA (447 bp), lane 2: parC (395 bp), lane 3: gyrA + parC, lane 4: negative control, lane 5: gyrA + parC, lane 6: negative control, and lane 7: molecular weight marker (100 bp).
Shukla Das (499655), Shafiul Haque (417403), Praveen Kumar Singh (6597671), Naseem Akhter (501211), Sajad Ahmad Dar (3602612), Taru Singh (3602633)   +5 more
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Characterization of gyrA and parC mutations in ciprofloxacin-resistant Pseudomonas aeruginosa isolates from Tehran hospitals in Iran

Iranian Journal of Microbiology, 2018
Background and Objectives: Pseudomonas aeruginosa, a major cause of several infectious diseases, has become a hazardous resistant pathogen. One of the factors contributing to quinolone resistance in P.
Rosetta Moshirian Farahi, Ahya Abdi Ali, Sara Gharavi   +2 more
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Fluoroquinolone resistance-conferring gyrA variants alter the fitness cost and potentiate the resistance of the zoliflodacin resistance mutation gyrBD429N in Neisseria gonorrhoeae

Antimicrobial Agents and Chemotherapy
Neisseria gonorrhoeae is a major public health concern due to its high global prevalence and rapid evolution of antibiotic resistance. A first-in-class topoisomerase inhibitor, zoliflodacin (a spiropyrimidinetrione), recently received FDA approval for ...
Aditi Mukherjee, Sofia O. P. Blomqvist, David Helekal, Daniel H. F. Rubin, Bailey Bowcutt, Samantha G. Palace, Yonatan H. Grad   +6 more
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gyrA alleles in 51 ciprofloxacin-nonsusceptible N. meningitidis strains.

, 2015
agyrA alleles were defined in this study based on nucleotides 115–639 of the gyrA gene.bIsolates assigned to any CC are shown with CC, while the isolates unable to be assigned are shown with ST.cAdditional alterations in ParE: R5, H495N; R6, A450V; R11 ...
Minggui Wang (401070), Mingliang Chen (210279), Ye Wang (41998), Xi Zhang (83736), Gangyi Wang (751969), Fupin Hu (341240), Min Chen (147733), Qinglan Guo (477828), Miao Zhao (527763), Xiaogang Xu (477826), Di Qu (66686), Ying Zou (46281)   +11 more
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