Results 111 to 120 of about 41,559 (188)

Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin

, 2018
Non-coding RNAs play an important role in the pathogenesis of pulmonary arterial hypertension (PAH). The aim of this study was to characterize the therapeutic role of melatonin as well as the underlying molecular mechanism (its effects on the expression ...
Xing Ding, Sijing Zhou, Luqian Zhou, Min Li, Xuexin Zhou, Guanghe Fei, Xuan Xu, Ran Wang, Peipei Wu, Chao Cao, Li Sun   +10 more
core   +1 more source

LncRNAH19 acts as a ceRNA of let-7 g to facilitate endothelial-to-mesenchymal transition in hypoxic pulmonary hypertension via regulating TGF-β signalling pathway

Respiratory Research
Background Hypoxic pulmonary hypertension (HPH) is a challenging lung arterial disorder with remarkably high incidence and mortality rates, and the efficiency of current HPH treatment strategies is unsatisfactory.
Xin Yu, Jiabing Huang, Xu Liu, Juan Li, Miao Yu, Minghui Li, Yuliang Xie, Ye Li, Junyu Qiu, Zhou Xu, Tiantian Zhu, Weifang Zhang   +11 more
doaj   +1 more source

Analysis of H19 and Igf2 expression in H19^hIC1Δ2.2/+ newborn mice.

, 2018
(A) Histograms of total H19 and Igf2 expression in three different neonatal organs of H19hIC1Δ2.2/+ and H19+/+ littermates analysed by RT-qPCR. The mean value of H19+/+ is set arbitrarily as 1. NS, Not Significant. Bars represent the mean ± SEM.
Federica Maria Valente (4875784), Andrea Freschi (3420212), Folami Y. Ideraabdullah (4875793), Andrea Riccio (272246), Stella K. Hur (4875787), Andrea Oneglia (4875778), Luca Colucci-D’Amato (650592), Diego Di Nucci (4875790), Joanne L. Thorvaldsen (4875781), Angela Sparago (272242), Marisa S. Bartolomei (328035), Flavia Cerrato (272244), Maria Teresa Gentile (704968)   +12 more
core   +1 more source

DNA methylation patterns at the IGF2-H19 locus in sperm of Swiss Landrace and Swiss Large White boars

, 2009
DNA methylation patterns at the IGF2-H19 locus were investigated in sperm DNA from Swiss Landrace (SL) and Swiss Large White (LW) boars. The putative IGF2 differentially methylated regions (DMR) 0, 1 and 2, a quantitative trait nucleotide (QTN) region in
Braunschweig, M., Giannini, P.
core   +1 more source

Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer

Cell Death Discovery
Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs with transcript lengths of >200 nucleotides. Mounting evidence suggests that lncRNAs are closely associated with tumorigenesis.
Yuyang Xia, Tianjiao Pei, Junjie Zhao, Zilin Wang, Yu Shen, Yang Yang, Jiayu Liang   +6 more
doaj   +1 more source

Clinical Significance and Therapeutic Potential of Long Non‐Coding RNA H19 in Soft Tissue Sarcoma

Cancer Medicine
Background Long non‐coding RNA (lncRNA) H19 plays a pivotal role in the pathogenesis of different human cancers, but its role in soft tissue sarcoma (STS) has not yet been defined. Methods We analyzed H19 expression patterns in various cancer cell lines,
Stephan Jahn, Katarina Krajina, Maria Anna Smolle, Dimyana Neufeldt, Katharina Jonas, Beate Rinner, Kevin Mellert, Maxim Noeparast, Martin Trepel, Joanna Szkandera, Martin Pichler, Bernadette Liegl‐Azwanger   +11 more
doaj   +1 more source

Contributions and roles in tumorigenesis of non-coding RNA expressed at the H19/IGF2 locus : H19 and 91H

, 2016
Le locus H19/IGF2 est soumis à l’empreinte génomique. A partir de l’allèle maternel, deux ARN non codants sont exprimés : H19 et 91H. L’ARN H19 est le précurseur de microARN (miR-675) dont aucune cible n’a été décrite dans la glande mammaire.
Vennin, Constance
core  

H19: A Regulatory Biomarker with Prognostic Value in Leukemias

, 2019
There are pieces of evidence indicating the important role of long noncoding RNAs (lncRNA) with transcription factors and their effect on gene expression at transcription and epigenetic levels.
Khodadi, E., Shahjahani, M., Pezeshki, S. M. S., Shahrabi, S., Ghanavat, M.   +4 more
core   +1 more source

An EED/PRC2‐H19 Loop Regulates Cerebellar Development

EED (embryonic ectoderm development) is a core subunit of the polycomb repressive complex 2 (PRC2), which senses the trimethylation of histone H3 lysine 27 (H3K27). However, its biological function in cerebellar development remains unknown. Here, we show
Yun‐Gui Yang, Xiao Han, Pei‐Pei Liu, Xiao Li, Li‐Hua Zhao, Zhao‐Qian Teng, Lin‐Fei Jiao, Shang‐Kun Dai, Ya‐Jie Xu, Hong‐Zhen Du, Rong‐Feng Li, Chang‐Mei Liu   +11 more
core   +1 more source

Long Noncoding RNA <i>H19</i> Inhibits Differentiation and Function of Secretory Lineage Cells in the Intestinal Epithelium by Targeting ATOH1. [PDF]

Noncoding RNA
Kwon MS, Chung HK, Chen H, VanderStoep A, Warner B, Zhao H, Atluri P, Tesfayohannes E, Turner DJ, Xiao L, Wang JY.   +10 more
europepmc   +1 more source