Results 91 to 100 of about 41,559 (188)

Non‐invasive biomarkers in biliary atresia: A scoping review of fibrosis assessment, translational readiness and clinical implementation gaps

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Biomarkers are positioned by their highest developmental stage. Most biomarkers remain in exploratory phases, with serum MMP‐7 and elastography showing the greatest translational maturity. This highlights the primary challenge is the transition from biomarker discovery to clinical implementation.
Elizabeth Brits, Stephen Brown, Lezelle Botes, Michael Pienaar   +3 more
wiley   +1 more source

The effects of placental long noncoding RNA H19 polymorphisms and promoter methylation on H19 expression in association with preeclampsia susceptibility

, 2020
The effect of DNA methylation on gene expression triggered it as a susceptibility factor in various diseases including preeclampsia (PE). The pathogenesis of PE is closely associated with the methylation status and genetic variants of relevant genes ...
Salimi, S., Mehrabani, M., Harati-Sadegh, M., Kohan, L., Teimoori, B.   +4 more
core  

Assessment of Circulating lncRNA H19 in Ankylosing Spondylitis Patients and Its Correlation with Disease Activity

, 2023
Ankylosing spondylitis (AS) is a chronic inflammatory disease that results in severe pain and stiffness in the joints. The causes and pathophysiology of AS are still largely unknown.
Amany M. Ebaid, Marwa M. Esawy, Amir Abd-elhameed, Murad A. Mubaraki, Mohamed A. Dkhil, Felwa A. Thagfan, Ahmed S. Alazzouni, Marwa A. Shabana   +7 more
core   +1 more source

H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2017
The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated.
Shanwen Chen, Dingfang Bu, Yuanyuan Ma, Jing Zhu, Guowei Chen, Lie Sun, Shuai Zuo, Tengyu Li, Yisheng Pan, Xin Wang, Yucun Liu, Pengyuan Wang   +11 more
doaj   +1 more source

Understanding the Potential of Antibody‐Drug Conjugates Functionalized Engineered Exosomes in Hepatocellular Carcinoma Therapy: A Comprehensive Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Exosomes are naturally secreted nanovesicles with high biocompatibility, low immunogenicity, and the ability to traverse biological barriers, making them attractive theragnostic carriers. When engineered to present tumor‐specific antibodies and to deliver antibody‐drug conjugates (ADCs), they may enhance selective targeting of ...
Subham Sarkar, Avinaba Bose, Jenifer Rajak, Arup Kumar Mitra, Ajoy Kumer, Bikram Dhara   +5 more
wiley   +1 more source

Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response

MedComm, Volume 7, Issue 10, October 2026.
Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu, Jie Yu, Ying Chen, Shengfang Ge, Lin Ye, Yefei Wang, Yixiong Zhou, Renbing Jia   +7 more
wiley   +1 more source

Abstract 2769: Long non coding RNA H19/cell adhesion molecules circuitry as novel target and diagnostic tool for metastatic prostate cancer

In the complex tumor biology of prostate cancer (PCa), we previously contributed by demonstrating that estrogen receptor and hypoxia signaling promoted transcription of progression-associated genes.
De Martino, Sara, Gaetano, Carlo, Farsetti, Antonella, Grassi, Claudio, Ripoli, Cristian, Rotili, Dante, Nanni, Simona, Pontecorvi, Alfredo, Strigari, Lidia, Pecci, Valeria, Pinto, Francesco, Aiello, Aurora, Pierconti, Francesco   +12 more
core   +1 more source

Identification and Functional Analysis of tRNA‐Derived Small RNAs in the Lung Tissues of Patients With Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
ABSTRACT Idiopathic pulmonary arterial hypertension (IPAH) is a pulmonary vascular disease with a poor prognosis. Its pathogenesis remains unclear and the treatment methods are limited. The expression of tRNA‐derived small RNA (tsRNA) in IPAH tissues remains unknown. tsRNA sequencing was conducted on lung tissue samples obtained from patients with IPAH
Yuan Chen, Ziqi E, Jintao Zhou, Feifan Ge, Jian Xu, Shugao Ye, Jialong Liang, Bin Ni   +7 more
wiley   +1 more source

CTCF Expression and H19 Promoter Methylation.

, 2015
Fig 9A: Increased CTCF transcript level correlates with demethylation of the H19 Promoter. Those samples with the highest CTCF expression were the least methylated ranging from 34% to 14%.
Laura Tom (817844), Xiaopan Yao (404808), Brent Schultz (817841), Milton Waner (817842), Yanhong Deng (284485), Deepak Narayan (267058), Christopher Spock (817843), John Persing (817845)   +7 more
core   +1 more source

The Interaction Between MiR-141 and lncRNA-H19 in Regulating Cell Proliferation and Migration in Gastric Cancer

Cellular Physiology and Biochemistry, 2015
Background/Aims: Non-coding RNAs including miRNA and lncRNA had been reported to regulate gene expression and were both related to cancer progression.
Xiaoying Zhou, Feng Ye, Chengqiang Yin, Ya Zhuang, Ge Yue, Guoxin Zhang   +5 more
doaj   +1 more source