Results 101 to 110 of about 41,559 (188)

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1667-1685, October 2026.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu, Yu Fang, Meirong Xu, Zuopeng Lu, Yu Cao, Yana Gao   +5 more
wiley   +1 more source

The H19 locus acts in vivo as a tumor suppressor

, 2008
The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated in some human tumors, such as Wilms' tumors.
Gabory, Anne, Terris B, Yoshimizu T, Vernucci M, Ripoche MA, Dandolo L., Yoshimizu, Tomomi, Miroglio A, Godard C, Jammes H, Godard, Cécile, Jammes, Hélène, Gabory A, Colnot S, Miroglio, Audrey, Vernucci, Maria, RICCIO, Andrea, Ripoche, Marie-Anne, Colnot, Sabine, Dandolo, Luisa, Terris, Benoît   +20 more
core   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Relative H19/Igf2 transcripts in early embryos.

, 2015
A, relative Igf2 transcripts at 1-cell, 2-cell, 4-cell, 8-cell and blastocyst stages of IVF, NT-CON and NT-TSA embryos, B, H19 transcripts in IVF embryos, and B', H19 transcripts in blastocysts of IVF, NT-CON and NT-TSA embryos.
Yanjun Huan (220372), Yanshuang Mu (371081), Qingran Kong (220382), Jiang Zhu (40858), Bo Huang (30906), Zhonghua Liu (148625)   +5 more
core   +1 more source

Hypomethylation of the LncRNA H19 promoter accelerates osteogenic differentiation of vascular smooth muscle cells by activating the Erk1/2 pathways

Journal of International Medical Research
Objective Vascular calcification is a common chronic kidney disease complication. This study aimed to investigate the function of long non-coding RNA (LncRNA) H19 in vascular calcification to explore new therapeutic strategies.
Taoxia Wang, Meijuan Cheng, Jingjing Jin, Yaling Bai, Dongxue Zhang, Shenglei Zhang, Jinsheng Xu   +6 more
doaj   +1 more source

LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing Sirt1/FoxO1

Cellular & Molecular Biology Letters, 2017
Background H19 is a well-characterized Long noncoding RNA (lncRNA) that has been proven to promote myoblast differentiation in humans and mice. However, its mechanism of action is still not fully interpreted.
Xiaochun Xu, Shengyue Ji, Weili Li, Bao Yi, Hengxin Li, Hongfu Zhang, Wenping Ma   +6 more
doaj   +1 more source

Developmentally regulated functions of the H19 differentially methylated domain

, 2004
Igf2 and H19 are physically linked imprinted genes. In embryonic liver, their reciprocal expression (paternal for Igf2 and maternal for H19) is controlled by a paternally methylated region (H19 DMD) located 5′ of H19.
DANDOLO L., PEDONE, Paolo Vincenzo, BRUNI C. B., CERRATO, Flavia, RICCIO, Andrea, VERNUCCI M.   +5 more
core   +1 more source

Epigenetic lesions at the H19 locus in Wilms' tumour patients

, 1994
To test the potential role of H19 as a tumour suppressor gene we have examined its expression and DNA methylation in Wilms\u27 tumours (WTs). In most WTs (18/25), H19 RNA was reduced at least 20–fold from fetal kidney levels.
Wilma Kraus, Loew, Thomas, Hao, Yue, Benjamin Tycko, Moosikasuwan, Josh, Gerald, William, Kraus, Wilma, Lin, Na, Josh Moosikasuwan, Tycko, Benjamin, Crenshaw, Taria, Thomas Loew, Lydia McMorrow, Na Lin, Francine Dembitzer, Weiss, Lawrence, William Gerald, Terrence Hensle, Taria Crenshaw, Yue Hao, Moulton, Thomas, Dembitzer, Francine, Thomas Moulton, McMorrow, Lydia, Hensle, Terrence, Lawrence Weiss   +25 more
core   +1 more source

Assisted Reproductive Technology affects developmental kinetics, H19 Imprinting Control Region methylation and H19 gene expression in individual mouse embryos

, 2007
Background: In the last few years, an increase in imprinting anomalies has been reported in children born from Assisted Reproductive Technology (ART).
Vaiman, Daniel, Fauque, Patricia, Luisa Dandolo, Daniel Vaiman, Jammes, Hélène, Patricia Fauque, Jouannet, Pierre, Pierre Jouannet, Hélène Jammes, Marie-Anne Ripoche, Lesaffre, Corinne, Ripoche, Marie-Anne, Dandolo, Luisa, Corinne Lesaffre   +13 more
core   +1 more source

H19 Induces Abdominal Aortic Aneurysm Development and Progression

, 2018
Background: Long noncoding RNAs have emerged as critical molecular regulators in various biological processes and diseases. Here we sought to identify and functionally characterize long noncoding RNAs as potential mediators in ...
Dueck, Anne,, Daniel Y. Li, Dacken, Brian, Tsao, Philip S., Deepak Ramanujam, Lars Maegdefessel, Sennblad, B., Spin, J. M., Eriksson, Per, Alexandra Bäcklund, Eckstein, Hans-Henning, Boon, R. A., Pelisek, Jaroslav, Sennblad, Bengt, Jin, H., Li, D. Y., Chernogubova, Ekaterina, Maegdefessel, Lars,, Shengliang Liu, Maegdefessel, L., Busch, Albert, Hofmann, P., Karlsson, Joakim, Eken, S. M., Li, Daniel Y.,, Reinier A. Boon, Jin, Hong,, Engelhardt, Stefan,, Eken, Suzanne M., Liu, Shengliang,, Patrick Hofmann, Roy, J., Pelisek, J., Hofmann, Patrick, Suzanne M. Eken, Ramanujam, D., Shen Lao, Lao, S., Lao, Shen, Eken, Suzanne M.,, Ramanujam, Deepak,, Joakim Karlsson, Maegdefessel, Lars, Chernogubova, Ekaterina,, Engelhardt, Stefan, Jin, Hong, Ekaterina Chernogubova, Per Eriksson, Karlsson, Joakim,, Eckstein, H. H., Eckstein, Hans-Henning,, Eriksson, P., Jaroslav Pelisek, Anne Dueck, Stefan Engelhardt, Engelhardt, S., Spin, Joshua M.,, Ramanujam, Deepak, Boon, Reinier A., Hans-Henning Eckstein, Tsao, Philip S.,, Li, Daniel Y., Chernogubova, E., Tsao, P. S., Hofmann, Patrick,, Brian Dacken, Busch, Albert,, Dueck, Anne, Spin, Joshua M., Boon, Reinier A.,, Liu, Shengliang, Dacken, Brian,, Liu, S. L., Joshua M. Spin, Dueck, A., Pelisek, Jaroslav,, Eriksson, Per,, Roy, Joy, Bengt Sennblad, Philip S. Tsao, Roy, Joy,, Albert Busch, Dacken, B., Hong Jin, Baecklund, Alexandra, Sennblad, Bengt,, Baecklund, Alexandra,, Busch, A., Joy Roy, Backlund, A.   +89 more
core   +1 more source