Results 81 to 90 of about 41,559 (188)

H19: a potential therapeutic target in gliomas [PDF]

Gliomas are aggressive glial cell tumors that are nearly impossible to treat successfully, yielding strikingly low survival rates for patients. Glioblastomas, the most severe type of gliomas, have even poorer prognoses. In the past decade, new literature
Roy, Suhita
core   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity [PDF]

, 2012
Extent: 11p.Imprinted genes play important roles in placental differentiation, growth and function, with profound effects on fetal development. In humans, H19 and IGF2 are imprinted, but imprinting of IGF2R remains controversial.
Stefan Hiendleder, Sam Buckberry, Tina Bianco-Miotto (116492), Bianco-Miotto, T., Claire T. Roberts (103366), Roberts Claire T., Claire T Roberts, Hiendleder, S., Stefan Hiendleder (103381), Tina Bianco-Miotto, Sam Buckberry (116490), Roberts, C., Hiendleder Stefan, Buckberry Sam, Bianco-Miotto Tina, Buckberry, S.   +15 more
core   +1 more source

Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus

Epigenetics & Chromatin, 2020
Background Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes.
Hitomi Matsuzaki, Daichi Kuramochi, Eiichi Okamura, Katsuhiko Hirakawa, Aki Ushiki, Keiji Tanimoto   +5 more
doaj   +1 more source

Cloud Microphysics and Drizzle Relationships With CCN Modality in Southern Ocean Stratocumuli

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 19, 16 October 2026.
Abstract Extended‐range high resolution cloud condensation nuclei (CCN) modality relationships to cloud microphysics and drizzle of the First Aerosol Characterization Experiment (ACE 1) were consistent with Physics of Stratocumulus Tops (POST) and Marine Stratus/Stratocumulus Experiment (MASE) observations.
James G. Hudson, Fatma Emin, Stephen Noble   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

A Combination of Alleles in LMOD2 and a lncRNA is Strongly Associated With Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT A previous genome‐wide association study identified regions on canine chromosome (cfa) 13 and 14 associated with early onset myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCS). In the present study, whole genome sequencing (WGS) of 9 CKCS cases (mitral regurgitation (MR) before 4.5 years or congestive heart failure
Lisbeth Høier Olsen, Arney Eva Gunnlaugsdóttir, Majbritt Busk Madsen, Isabella Jane Larsen, Maria Josefine Ubbe Reimann, Foteini Papadaki, Ingrid Ljungvall, Jens Häggström, Torben Martinussen, Henrik Duelund Pedersen, Torkel Falk, Merete Fredholm, Peter Karlskov‐Mortensen   +12 more
wiley   +1 more source

Return to Classical Paradigm in Public Administration Theory?: A Study on Neoweberian and Neotaylorist Theory

Foundations of Management
Weberian and Taylorist administrative theories can be attributed to organizational requirements that arose with the Industrial Revolution. In Weberian administration, it is believed that the legal-rational bureaucracy is best type organization, which has
DEMİREL Demokaan
doaj   +1 more source

Long Noncoding RNA H19 Induces Neuropathic Pain by Upregulating Cyclin-Dependent Kinase 5-Mediated Phosphorylation of cAMP Response Element Binding Protein

Journal of Pain Research, 2020
Kai Li,1 Yuan Jiao,1 Xuli Ren,1 Di You,1 Rangjuan Cao2 1Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130021, Jilin, People’s Republic of China; 2Department of Hand-Surgery, China-Japan Union Hospital of ...
Li K, Jiao Y, Ren X, You D, Cao R
doaj  

Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases

Diseases, 2017
H19 is a long non-coding RNA regulated by genomic imprinting through methylation at the locus between H19 and IGF2. H19 is important in normal liver development, controlling proliferation and impacting genes involved in an important network controlling ...
Chad Pope, Shashank Mishra, Joshua Russell, Qingqing Zhou, Xiao-Bo Zhong   +4 more
doaj   +1 more source