Results 31 to 40 of about 41,559 (188)

H19 Rises in Gastric Cancer and Exerts a Tumor-Promoting Function via miR-138/E2F2 Axis

Cancer Management and Research, 2020
Jingrong Yu, 1,* Cheng Fang, 2,* Ziyue Zhang, 2 Guifang Zhang, 3 Lihong Shi, 4 Jiayi Qian, 5 Jianping Xiong 6 1Department of Oncology, The Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330003, People’s Republic of ...
Yu J, Fang C, Zhang Z, Zhang G, Shi L, Qian J, Xiong J   +6 more
doaj  

Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19

, 2022
S.43-59Myocardial ischemia induces a multifaceted remodeling process in the heart. Novel therapeutic entry points to counteract maladaptive signalling include the modulation of non-coding RNA molecules such as long non-coding RNA (lncRNA).
Frantz, S., Schmidt, A., Ramos, G.C., Just, A., Wollert, K.C., Zimmer, K., Remke, J., Viereck, J., Reamon-Buettner, S.M., Loyer, X., Pich, A., Boulanger, C., Foinquinos, A., Nowak, J., Xiao, K., Kenneweg, F., Wang, Y., Jung, M., Mazlan, S., Fiedler, J., Thum, T., Hobuß, L.   +21 more
core   +1 more source

Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription

Journal of Translational Medicine, 2023
Background Peritoneal dialysis (PD) remains limited due to dialysis failure caused by peritoneal fibrosis. Tamoxifen (TAM), an inhibitor of estrogen receptor 1 (ESR1), has been reported to treat fibrosis, but the underlying mechanism remains unknown.
Tingting Zhao, Zhengyu Sun, Xueli Lai, Hongtao Lu, Lulu Liu, Shuangxi Li, Ji-hang Yuan, Zhiyong Guo   +7 more
doaj   +1 more source

Long Non-Coding RNA H19 Promotes Proliferation, Migration and Invasion and Inhibits Apoptosis of Breast Cancer Cells by Targeting miR-491-5p/ZNF703 Axis

Cancer Management and Research, 2020
Yongkun Wang,1,* Zhen Wu,1,* Yingxue Li,2 Zheng Zheng,2 Jinqiang Yan,2 Shuyan Tian,2 Lin Han2 1Department of Thyroid Surgery, Liaocheng People’s Hospital (Clinical Hospital of Shandong First Medical University) Liaocheng, Shandong, People’s ...
Wang Y, Wu Z, Li Y, Zheng Z, Yan J, Tian S, Han L   +6 more
doaj  

Exosome-transported lncRNA H19 regulates insulin-like growth factor-1 via the H19/let-7a/insulin-like growth factor-1 receptor axis in ischemic stroke

Neural Regeneration Research, 2023
LncRNA (long non-coding RNA) H19 is a transcript of the H19 gene that is expressed during embryogenesis. We previously discovered a role for circular lncRNA H19 in the onset and prognosis of cerebral ischemic stroke.
Jue Wang, Bin Cao, Yan Gao, Yu-Hua Chen, Juan Feng   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase [PDF]

, 2015
DNA methylation is essential for mammalian development and physiology. Here we report that the developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S ...
Men, Yi, Carmichael, Gordon G, Huang, Yingqun, Yang, Lihua, Xie, Juanke, Lu, Lingeng, Zhang, Na, Zhong, Tianyu, Taylor, Hugh S, Chung, Hunter, Zhou, Jichun, Müller, Martin, Giang, Karolyn, Sun, Xueguang   +13 more
core   +2 more sources

Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma

Molecular Cancer
Background The insulin-like growth factor 2 (IGF2) and H19 are overexpressed in hepatocellular carcinoma (HCC). IGF2-derived miR-483-5p is implicated in the development of cancers.
Weiwei Chen, Chutian Wu, Yuting Li, Tonghua Wang, Miaoling Huang, Min Wang, Linjing Long, Yanfang Chen, Shufen Feng, Xuyou Liu, Shaohui Tang   +10 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Aerosolized BC-819 inhibits primary but not secondary lung cancer growth. [PDF]

, 2011
Despite numerous efforts, drug based treatments for patients suffering from lung cancer remains poor. As a promising alternative, we investigated the therapeutic potential of BC-819 for the treatment of lung cancer in mouse tumor models.
Corinna Pfeifer, Patricia Ohana, Wagner Kai, Carsten Rudolph, Aneja, Manish Kumar, Gilon, Michal, Hochberg, Avraham, Pfeifer, Corinna, Ohana, Patricia, Hasenpusch, Günther, Kai Wagner, Günther Hasenpusch, Gilon Michal, Ohana Patricia, Rudolph, Carsten, Michal Gilon, Hasenpusch Günther, Manish Kumar Aneja, Pfeifer Corinna, Avraham Hochberg, Reinhardt Dietrich, Wagner, Kai, Reinhardt, Dietrich, Aneja Manish Kumar, Hochberg Avraham, Rudolph Carsten, Dietrich Reinhardt   +26 more
core   +2 more sources