Results 1 to 10 of about 41,916 (253)

Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs

eLife, 2023
Influenza A viruses in animal reservoirs repeatedly cross species barriers to infect humans. Dogs are the closest companion animals to humans, but the role of dogs in the ecology of influenza viruses is unclear.
Mingyue Chen, Yanli Lyu, Fan Wu, Ying Zhang, Hongkui Li, Rui Wang, Yang Liu, Xinyu Yang, Liwei Zhou, Ming Zhang, Qi Tong, Honglei Sun, Juan Pu, Jinhua Liu, Yipeng Sun   +14 more
doaj   +3 more sources

Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants

Scientific Reports, 2022
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic variants.
Yura Shin, Jeonghun Kim, Jong Hyeon Seok, Heedo Park, Hye-Ran Cha, Si Hwan Ko, Jae Myun Lee, Man-Seong Park, Jung-Hwan Park   +8 more
doaj   +2 more sources

A changing trend in diagnostic methods of Influenza A (H3N2) virus in human: a review [PDF]

3 Biotech, 2021
The influenza virus is classified into four types A, B, C, and D, but type A and B are responsible for major illnesses in people with influenza A being the only virus responsible for flu pandemics due to the presence of two surface proteins called ...
Ravina Ravina, Manjeet, Hari Mohan, Jagriti Narang, Shikha Pundir, Chandra Shekhar Pundir   +5 more
openalex   +2 more sources

An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

npj Vaccines, 2022
There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons.
Brianna L. Bullard, Jennifer DeBeauchamp, Matthew J. Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J. Webby, Eric A. Weaver   +6 more
doaj   +2 more sources

H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation

Human Vaccines & Immunotherapeutics, 2018
Annual seasonal influenza vaccines are composed of two influenza A strains representing the H1N1 and H3N2 subtypes, and two influenza B strains representing the Victoria and Yamagata lineages.
James D. Allen, Ted M. Ross
doaj   +2 more sources

The order of infection shapes disease outcomes in influenza and herpes simplex virus coinfection by modulating immune responses [PDF]

Virology Journal
Background Coinfections of influenza A virus (IAV) and herpes simplex virus type 1 (HSV-1) have been increasingly reported in patients with severe pneumonia, yet their pathogenesis remains poorly understood.
Yuanjun Lyu, Kailin Mai, Hongxuan Zhou, Chunguang Yang, Yunceng Weng, Zhenhui Zhang, Yang Wang, Zifeng Yang   +7 more
doaj   +2 more sources

Influenza Surveillance in the Central African Republic From 2015 to 2018 to Inform Vaccination and Treatment Strategies. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background Surveillance of influenza infections and virus characterisation are essential to guide prevention strategies. In the Central African Republic (CAR), data on influenza viruses are patchy and poorly documented. Objective To study the clinical, seasonal, genetic and phenotypic characteristics of influenza viruses circulating in the CAR
Komoyo GF, Snoeck CJ, Daniels RS, Belizaire MR, Hübschen JM, Muller CP, Somse P, Boum Y, Nakoune E, McCauley JW.   +9 more
europepmc   +2 more sources

Novel introductions of human-origin H3N2 influenza viruses in swine, Chile [PDF]

Frontiers in Veterinary Science
Influenza A virus (IAV) continuously threatens animal and public health globally, with swine serving as a crucial reservoir for viral reassortment and evolution.
Belen Monserrat Agüero, Naomi Ariyama, Felipe Berrios, Nikita Enciso, Barbara Quezada, Rafael A. Medina, Rafael A. Medina, Victor Neira, Victor Neira   +8 more
doaj   +2 more sources

Chronology of H3N2 human influenza virus surface glycoprotein adaptation from 1968 to 2019 reveals a surge of adaptation between 1997 and 2002 [PDF]

Journal of Virology
Subtype H3N2 influenza A viruses (IAVs), which emerged in 1968 to cause a pandemic, have shown continual circulation and adaptation that has necessitated frequent updates of candidate vaccine viruses.
Hui Lei, Biying Xiao, Xia Lin, Zaolan Liang, Shiman Ling, Yaqin Bai, Vijaykrishna Dhanasekaran, Wenjun Song, Sook-San Wong, Mark Zanin   +9 more
doaj   +2 more sources

Paradoxical clade- and age-specific vaccine effectiveness during the 2018/19 influenza A(H3N2) epidemic in Canada: potential imprint-regulated effect of vaccine (I-REV)

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019
Introduction The Canadian Sentinel Practitioner Surveillance Network reports vaccine effectiveness (VE) for the 2018/19 influenza A(H3N2) epidemic. Aim To explain a paradoxical signal of increased clade 3C.3a risk among 35–54-year-old vaccinees, we ...
Danuta M. Skowronski, Suzana Sabaiduc, Siobhan Leir, Caren Rose, Macy Zou, Michelle Murti, James A. Dickinson, Romy Olsha, Jonathan B. Gubbay, Matthew A. Croxen, Hugues Charest, Nathalie Bastien, Yan Li, Agatha N. Jassem, Mel Krajden, Gaston De Serres   +15 more
openalex   +2 more sources