Results 81 to 90 of about 41,916 (253)

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Phylogenetic analysis of swine influenza viruses circulating in slaughterhouses in Thanh Hoa province, Vietnam, during 2024 and early 2025

Open Veterinary Journal
Background: Swine influenza (SIV) is a highly infectious viral disease in pig population. This disease is caused by the influenza A virus. According to the World Organization for Animal Health (WOAH), three subtypes of SIVs have been officially reported,
Anh Duc Truong, Ha Thi Thanh Tran, Duy Le Khac, Uyen Trung Nguyen, Hiep Van Dang, Nhu Thi Chu, Hieu Minh Nguyen, Linh Thi Nguyen, Kien Van Le, Hoang Vu Dang   +9 more
doaj   +1 more source

Phosphoproteomics to Characterize Host Response During H3N2 Canine Influenza Virus Infection of Dog Lung

Frontiers in Veterinary Science, 2020
Avian-origin H3N2 canine influenza viruses (CIVs) cause severe contagious respiratory disease in dogs, and quickly adapt to new environments. To further understand the mechanism of virus infection and host-virus interactions, we characterized the ...
Yongbo Liu, Yongbo Liu, Yongbo Liu, Cheng Fu, Shaotang Ye, Shaotang Ye, Shaotang Ye, Yingxin Liang, Yingxin Liang, Yingxin Liang, Zhonghe Qi, Zhonghe Qi, Zhonghe Qi, Congwen Yao, Congwen Yao, Congwen Yao, Zhen Wang, Zhen Wang, Zhen Wang, Ji Wang, Ji Wang, Ji Wang, Siqi Cai, Siqi Cai, Siqi Cai, Shiyu Tang, Shiyu Tang, Shiyu Tang, Ying Chen, Ying Chen, Ying Chen, Shoujun Li, Shoujun Li, Shoujun Li   +33 more
doaj   +1 more source

Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses

Frontiers in Immunology, 2023
Porcine respiratory disease is multifactorial and most commonly involves pathogen co-infections. Major contributors include swine influenza A (swIAV) and porcine reproductive and respiratory syndrome (PRRSV) viruses.
Tiphany Chrun, Emmanuel A. Maze, Kelly J. Roper, Eleni Vatzia, Basudev Paudyal, Adam McNee, Veronica Martini, Tanuja Manjegowda, Graham Freimanis, Adrian Silesian, Noemi Polo, Becky Clark, Emily Besell, Georges Booth, Brigid Veronica Carr, Matthew Edmans, Alejandro Nunez, Surapong Koonpaew, Nanchaya Wanasen, Simon P. Graham, Elma Tchilian   +20 more
doaj   +1 more source

Interaction analysis of non‐bacterial respiratory pathogens during and after the coronavirus disease 2019 pandemic in two cities along the eastern coast of China

Pediatric Investigation, EarlyView.
What is Known • Co‐infections can influence pathogen replication, disease severity, and the duration of illness. • Co‐infection patterns and temporal correlations have been characterized among various respiratory viruses and atypical pathogens. What is New • A consistent negative correlation between influenza B and Mycoplasma pneumoniae suggests ...
Wanxian Ye, Jishan Zheng, Yungang Yang, Xinyue Song, Xiang Yuan, Lan Yang, Jian Yu, Hailin Zhang, Shunhang Wen   +8 more
wiley   +1 more source

Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China

Frontiers in Microbiology, 2020
An influenza A (H3N2) virus epidemic occurred in China in 2017 and the causative strain failed to bind red blood cells (RBCs), which may affect receptor binding and antibody recognition.
Zhiqi Zeng, Lee-Fong Yau, Zengxian Lin, Xuanzi Xia, Zifeng Yang, Zifeng Yang, Jing-Rong Wang, Wenjun Song, Wenjun Song, Xinhua Wang, Xinhua Wang   +10 more
doaj   +1 more source

Characterization of Canine Influenza Virus A (H3N2) Circulating in Dogs in China from 2016 to 2018

Viruses, 2021
Avian H3N2 influenza virus follows cross-host transmission and has spread among dogs in Asia since 2005. After 2015–2016, a new H3N2 subtype canine influenza epidemic occurred in dogs in North America and Asia.
Yuanguo Li, Xinghai Zhang, Yuxiu Liu, Ye Feng, Tiecheng Wang, Ye Ge, Yunyi Kong, Hongyu Sun, Haiyang Xiang, Bo Zhou, Shushan Fang, Qing Xia, Xinyu Hu, Weiyang Sun, Xuefeng Wang, Keyin Meng, Chaoxiang Lv, Entao Li, Xianzhu Xia, Hongbin He, Yuwei Gao, Ningyi Jin   +21 more
doaj   +1 more source

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, EarlyView.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source

Predominance of a Drifted Influenza A (H3N2) Clade and its Association with Age-specific Influenza Vaccine Effectiveness Variations, Influenza Season 2018–2019

Vaccines, 2020
Background: Influenza A (H3N2) clade 3C.3a was the predominant influenza virus in Israel throughout the 2018-2019 season, constituting a drift from the influenza A (H3N2) vaccine.
Aharona Glatman-Freedman, Rakefet Pando, Hanna Sefty, Itay Omer, Alina Rosenberg, Yaron Drori, Ital Nemet, Ella Mendelson, Lital Keinan-Boker, Michal Mandelboim, for the Israeli Influenza Surveillance Network (IISN)   +10 more
doaj   +1 more source

Large language models for bioinformatics

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract With the rapid advancements in large language model technology and the emergence of bioinformatics‐specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications.
Wei Ruan, Yanjun Lyu, Jing Zhang, Jiazhang Cai, Peng Shu, Yang Ge, Yao Lu, Shang Gao, Yue Wang, Peilong Wang, Lin Zhao, Tao Wang, Yufang Liu, Luyang Fang, Ziyu Liu, Zhengliang Liu, Yiwei Li, Zihao Wu, Junhao Chen, Hanqi Jiang, Yi Pan, Zhenyuan Yang, Jingyuan Chen, Shizhe Liang, Wei Zhang, Terry Ma, Yuan Dou, Jianli Zhang, Xinyu Gong, Qi Gan, Yusong Zou, Zebang Chen, Yuanxin Qian, Shuo Yu, Jin Lu, Kenan Song, Xianqiao Wang, Andrea Sikora, Gang Li, Xiang Li, Quanzheng Li, Yingfeng Wang, Lu Zhang, Yohannes Abate, Lifang He, Wenxuan Zhong, Rongjie Liu, Chao Huang, Wei Liu, Ye Shen, Ping Ma, Hongtu Zhu, Yajun Yan, Dajiang Zhu, Tianming Liu   +54 more
wiley   +1 more source