Results 1 to 10 of about 10,088 (188)

Whole blood RNA signatures in tuberculosis patients receiving H56:IC31 vaccine as adjunctive therapy [PDF]

Frontiers in Immunology
IntroductionTherapeutic vaccination in tuberculosis (TB) represents a Host Directed Therapy strategy which enhances immune responses in order to improve clinical outcomes and shorten TB treatment.
Noelia Alonso-Rodríguez, Eleonora Vianello, Suzanne van Veen, Synne Jenum, Kristian Tonby, Kristian Tonby, Rosalie van Riessen, Xiaoran Lai, Rasmus Mortensen, Tom H. M. Ottenhoff, Anne Ma Dyrhol-Riise, Anne Ma Dyrhol-Riise   +11 more
doaj   +5 more sources

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs [PDF]

Frontiers in Immunology
IntroductionAirway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways.
Ranmali Kavishna, Thorunn Asta Olafsdottir, Siggeir F. Brynjólfsson, Dennis Christensen, Tobias Gustafsson-Hedberg, Peter Andersen, Manuela Terrinoni, Jan Holmgren, Ali M. Harandi, Ali M. Harandi   +9 more
doaj   +2 more sources

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis. [PDF]

PLoS ONE, 2016
The search for new and improved tuberculosis (TB) vaccines has focused on IFN-γ both for selecting antigens and for evaluating vaccine delivery strategies.
Rolf Billeskov, Esterlina V Tan, Marjorie Cang, Rodolfo M Abalos, Jasmin Burgos, Bo Vestergaard Pedersen, Dennis Christensen, Else Marie Agger, Peter Andersen   +8 more
doaj   +4 more sources

A phase 1b randomized study of the safety and immunological responses to vaccination with H4:IC31, H56:IC31, and BCG revaccination in Mycobacterium tuberculosis-uninfected adolescents in Cape Town, South Africa [PDF]

EClinicalMedicine, 2020
Background: Tuberculosis (TB) remains the leading cause of infectious disease-related death. Recently, a trial of BCG revaccination and vaccination with H4:IC31, a recombinant protein vaccine, in South African adolescents (Aeras C-040-404) showed ...
Linda-Gail Bekker, One Dintwe, Andrew Fiore-Gartland, Keren Middelkoop, Julia Hutter, Anthony Williams, April K. Randhawa, Morten Ruhwald, Ingrid Kromann, Peter L. Andersen, Carlos A. DiazGranados, Kathryn T. Rutkowski, Dereck Tait, Maurine D. Miner, Erica Andersen-Nissen, Stephen C. De Rosa, Kelly E. Seaton, Georgia D. Tomaras, M. Juliana McElrath, Ann Ginsberg, James G. Kublin   +20 more
doaj   +3 more sources

Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone [PDF]

Frontiers in Immunology, 2020
Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and ...
Aneesh Thakur, Fernanda Endringer Pinto, Harald Severin Hansen, Peter Andersen, Dennis Christensen, Christian Janfelt, Camilla Foged   +6 more
doaj   +5 more sources

Antigen surface display in two novel whole genome sequenced food grade strains, Lactiplantibacillus pentosus KW1 and KW2 [PDF]

Microbial Cell Factories
Background Utilization of commensal bacteria for delivery of medicinal proteins, such as vaccine antigens, is an emerging strategy. Here, we describe two novel food-grade strains of lactic acid bacteria, Lactiplantibacillus pentosus KW1 and KW2, as well ...
Kamilla Wiull, Live Heldal Hagen, Jelena Rončević, Bjørge Westereng, Preben Boysen, Vincent G. H. Eijsink, Geir Mathiesen   +6 more
doaj   +2 more sources

[my]-Bis(diphenylphosphanyl)borato-[kappa]2P:P'-bis[dicarbonyl([eta]5-cyclopentadienyl)iron(II)] tetrachloridoferrate(III) chloroform solvate [PDF]

, 2008
The title compound, [Fe2(C5H5)2(C24H22BP2)(CO)4][FeCl4]·CHCl3, is an oxidation product of CpFe(CO)2PPh2BH3. One pair of phenyl rings attached to the two different P atoms are almost parallel, as are the other pair [dihedral angles = 8.7 (5) and 8.9 (5)°].
Franz Dornhaus, Hans-Wolfram Lerner, Michael Bolte, Blessing, Sheldrick, Spek   +5 more
core   +2 more sources

Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?

Vaccines, 2021
Characterizing the impact of the vaccination schedule on the induction of B and T cell immune responses is critical for improving vaccine immunogenicity.
Elena Pettini, Gabiria Pastore, Fabio Fiorino, Donata Medaglini, Annalisa Ciabattini   +4 more
doaj   +1 more source

Dynamic Common Correlated Effects of Geopolitical Risk on International Tourism Arrivals

Folia Oeconomica Stetinensia, 2023
Geopolitical risk is currently recognized as a worldwide concern that significantly affects various economic sectors. As a consequence, rising geopolitical risks can cause a decline in the number of tourist arrivals.
Herman Suzana
doaj   +1 more source

Conventional and Islamic Equity Market Reaction Towards Terrorism: Evidence Based on Target Types, Location and Islamic Calendar Months

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2023
This study investigates the conventional and Islamic equity market reaction towards terrorism events in Pakistan from 2009 to 2016 using OLS regression and GARCH (1, 1) models. The prospect theory and efficient market hypothesis are the relevant theories.
Irshad Hira, Taib Hasniza Mohd, Hussain Haroon, Hussain Rana Yassir   +3 more
doaj   +1 more source