Results 1 to 10 of about 209,439 (318)
Apical hair cells and hearing [PDF]
Hearing Research, 1990 This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Cynthia A. Prosen +7 more
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eLife, 2022 Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer +15 more
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Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration. [PDF]
PLoS ONE, 2016 Unlike mammals, the non-mammalian vertebrate inner ear can regenerate the sensory cells, hair cells, either spontaneously or through induction after hair cell loss, leading to hearing recovery.
Sang Goo Lee +11 more
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The role of epigenetic modifications in sensory hair cell development, survival, and regulation
Frontiers in Cellular Neuroscience, 2023 The cochlea is the sensory organ in the periphery, and hair cells are its main sensory cells. The development and survival of hair cells are highly controlled processes.
Ying Xiao, Dan Li
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Current Opinion in Neurobiology, 2008 The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Zheng-Yi Chen +2 more
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Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]
PLoS ONE, 2013 In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati +3 more
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Hair Follicle Stem Cells [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2003 The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle.
Lavker, Robert M +11 more
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eLife, 2023 A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi +7 more
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Myosin and Adaptation by Hair Cells [PDF]
Neuron, 1997 Conclusive identification of the adaptation motor is not entirely academic. For example, a rational approach to identifying other members of the transduction apparatus is first to identify one component—the adaptation motor seems most likely—and then to identify interacting proteins using biochemical and molecular biological methods.
Peter G. Gillespie, David P. Corey
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The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack [PDF]
Microarrays, 2013 Mature mammals exhibit very limited capacity for regeneration of auditory hair cells, while all non-mammalian vertebrates examined can regenerate them. In an effort to find therapeutic targets for deafness and balance disorders, scientists have examined gene expression patterns in auditory tissues under different developmental and experimental ...
Michael E. Smith, Gopinath Rajadinakaran
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