Results 1 to 10 of about 11,093,699 (378)

Hair cell damage recruited Lgr5-expressing cells are hair cell progenitors in neonatal mouse utricle [PDF]

Frontiers in Cellular Neuroscience, 2015
Damage-activated stem/progenitor cells play important roles in regenerating lost cells and in tissue repair. Previous studies reported that the mouse utricle has limited hair cell regeneration ability after hair cell ablation.
Fengfang Wu, Jinchao Lin, Weinian Lin, Xiaodong Zhang   +3 more
core   +9 more sources

Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]

PLoS ONE, 2013
In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati, Isabelle Roux, Elisabeth Glowatzki, Angelika Doetzlhofer   +3 more
doaj   +2 more sources

The transcriptome of utricle hair cell regeneration in the avian inner ear [PDF]

Journal of Neuroscience, 2014
Sensory hair cell loss is the major cause of hearing and balance disorders. Mammals are incapable of sustained hair cell regeneration, but lower vertebrates can regenerate these mechano-electrical transducers.
Helms, Cynthia, Ku, Yuan-Chieh, Lovett, Michael, Renaud, Nicole A, Veile, Rose A, Voelker, Courtney C J, Warchol, Mark E   +6 more
core   +3 more sources

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells, 2019
The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue ...
Pietro Gentile, Simone Garcovich
doaj   +2 more sources

Sensory hair cell death and regeneration in fishes

Frontiers in Cellular Neuroscience, 2015
Sensory hair cells are specialized mechanotransductive receptors required for hearing and vestibular function. Loss of hair cells in humans and other mammals is permanent and causes reduced hearing and balance.
Jerry D. Monroe, Gopinath eRajadinakaran, Michael E. Smith   +2 more
doaj   +2 more sources

Metabolic Profiling of Cochlear Organoids Identifies α‐Ketoglutarate and NAD+ as Limiting Factors for Hair Cell Reprogramming [PDF]

Advanced Science
Cochlear hair cells are the sensory cells responsible for transduction of acoustic signals. In mammals, damaged hair cells do not regenerate, resulting in permanent hearing loss.
Qing Liu, Linqing Zhang, Zhen Chen, Yihan He, Yuhang Huang, Cui Qiu, Chengwen Zhu, Danxia Zhou, Zhenji Gan, Xia Gao, Guoqiang Wan   +10 more
doaj   +2 more sources

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

eLife, 2022
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves   +15 more
doaj   +1 more source

The role of epigenetic modifications in sensory hair cell development, survival, and regulation

Frontiers in Cellular Neuroscience, 2023
The cochlea is the sensory organ in the periphery, and hair cells are its main sensory cells. The development and survival of hair cells are highly controlled processes.
Ying Xiao, Dan Li
doaj   +1 more source

Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration. [PDF]

PLoS ONE, 2016
Unlike mammals, the non-mammalian vertebrate inner ear can regenerate the sensory cells, hair cells, either spontaneously or through induction after hair cell loss, leading to hearing recovery.
Sang Goo Lee, Mingqian Huang, Nikolaus D Obholzer, Shan Sun, Wenyan Li, Marco Petrillo, Pu Dai, Yi Zhou, Douglas A Cotanche, Sean G Megason, Huawei Li, Zheng-Yi Chen   +11 more
doaj   +1 more source

Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

eLife, 2023
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi, Marielle O Beaulieu, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil, J Gage Crump, David W Raible   +7 more
doaj   +1 more source