Results 11 to 20 of about 551,648 (355)

Hair cell regeneration [PDF]

Current Opinion in Neurobiology, 2008
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Albert Sb, Edge, Zheng-Yi, Chen
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Hair Cell Generator Potentials [PDF]

The Journal of General Physiology, 1973
A technique is introduced using a piezoelectric device to stimulate hair cells of a molluscan statocyst while recording their responses intracellularly. Statocyst displacements produced with the technique are calibrated with stroboscopic photography. Properties of the hair cells' response to currents and mechanical stimulation are studied.
D L, Alkon, A, Bak
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Hair cell ribbon synapses [PDF]

Cell and Tissue Research, 2006
Hearing and balance rely on the faithful synaptic coding of mechanical input by the auditory and vestibular hair cells of the inner ear. Mechanical deflection of their stereocilia causes the opening of mechanosensitive channels, resulting in hair cell depolarization, which controls the release of glutamate at ribbon-type synapses.
Tobias, Moser, Andreas, Brandt, Anna, Lysakowski   +2 more
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Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source

Hair Follicle Stem Cells [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2003
The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle.
Lavker, Robert M, Sun, Tung-Tien, Oshima, Hideo, Barrandon, Yann, Akiyama, Masashi, Ferraris, Corinne, Chevalier, Genevieve, Favier, Bertrand, Jahoda, Colin a B, Dhouailly, Danielle, Panteleyev, Andrei A, Christiano, Angela M   +11 more
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Hair cell afferent synapses [PDF]

Current Opinion in Neurobiology, 2008
This review will cover advances in the study of hair cell afferent synaptic function occurring between 2005 and 2008. During this time, capacitance measurements of vesicular fusion have continued to be refined, optical methods have added insights regarding vesicle trafficking, and paired intracellular recordings have established the transfer function ...
Elisabeth, Glowatzki, Lisa, Grant, Paul, Fuchs   +2 more
openaire   +2 more sources

GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

Scientific Reports, 2022
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result, as ...
Hsin-I Jen, Sunita Singh, Litao Tao, Helen R. Maunsell, Neil Segil, Andrew K. Groves   +5 more
doaj   +1 more source

Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells

Frontiers in Cellular Neuroscience, 2021
Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer, Amrita A. Iyer, Andrew K. Groves, Andrew K. Groves, Andrew K. Groves   +4 more
doaj   +1 more source

Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible [PDF]

, 2008
The aminophospholipid phosphatidylserine (PS) is normally restricted to the inner leaflet of the plasma membrane. During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied ...
Gale, Jonathan E, Goodyear, Richard J, Kros, Corné J, Ranatunga, Kishani M, Richardson, Guy P   +4 more
core   +1 more source

Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium

iScience, 2023
Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga, Ryosuke Yamamoto, Tomoko Kita, Hiroe Ohnishi, Norio Yamamoto, Takayuki Okano, Koichi Omori, Takayuki Nakagawa   +7 more
doaj   +1 more source