Results 11 to 20 of about 11,288,087 (353)

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells, 2019
The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue ...
Pietro Gentile, Simone Garcovich
doaj   +2 more sources

Exosomes mediate sensory hair cell protection in the inner ear.

Journal of Clinical Investigation, 2020
Hair cells are the mechanosensory receptors of the inner ear, responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely-used aminoglycoside antibiotics ...
Andrew M. Breglio, Lindsey A. May, M. Barzik, Nora Welsh, Shimon P. Francis, Tucker Costain, Lizheng Wang, D. Eric Anderson, Ronald S. Petralia, Ya‐Xian Wang, Thomas B. Friedman, Matthew J.A. Wood, Lisa L. Cunningham   +12 more
semanticscholar   +1 more source

Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase

Scientific Reports, 2021
Hair follicles (HFs) are unique, multi-compartment, mini-organs that cycle through phases of active hair growth and pigmentation (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen).
Katarzyna Figlak, Greg Williams, Marta Bertolini, Ralf Paus, Michael P. Philpott   +4 more
doaj   +1 more source

Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source

GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

Scientific Reports, 2022
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result, as ...
Hsin-I Jen, Sunita Singh, Litao Tao, Helen R. Maunsell, Neil Segil, Andrew K. Groves   +5 more
doaj   +1 more source

Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants [PDF]

, 2018
Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was
A Roul, CH Dalton, D Josse, FSG Praça, G Skopp, H Eberhardt, H Matar, H Matar, HP Chan, JE Riviere, L Thors, M Houston, M Spiandore, M Spiandore, M Spiandore, N Kassouf, P Rolland, P Rolland, R Amlôt, RP Chilcott, RP Chilcott, RP Chilcott   +21 more
core   +3 more sources

Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]

, 2015
Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
core   +1 more source

scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

eLife, 2019
Loss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized support cells.
Mark E. Lush, Daniel C Diaz, Nina Koenecke, Sungmin Baek, H. Boldt, Madeleine St. Peter, Tatiana Gaitán-Escudero, Andrés Romero-Carvajal, E. Busch-Nentwich, Anoja Perera, Kate E. Hall, Allison Peak, J. Haug, T. Piotrowski   +13 more
semanticscholar   +1 more source

Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]

, 2019
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J., Gale, Jonathan E., Gonçalves, Ana Cláudia, Haq, Naila, Pelletier, Jerry, Porco, John A., Towers, Emily R.   +6 more
core   +2 more sources

Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag

Frontiers in Cell and Developmental Biology, 2018
The zebrafish inner ear organs and lateral line neuromasts are comprised of a variety of cell types, including mechanosensitive hair cells. Zebrafish hair cells are evolutionarily homologous to mammalian hair cells, and have been particularly useful for ...
Maggie S. Matern, Alisha Beirl, Yoko Ogawa, Yang Song, Nikhil Paladugu, Katie S. Kindt, Ronna Hertzano, Ronna Hertzano, Ronna Hertzano   +8 more
doaj   +1 more source