Results 11 to 20 of about 11,068,075 (352)

The role of epigenetic modifications in sensory hair cell development, survival, and regulation

Frontiers in Cellular Neuroscience, 2023
The cochlea is the sensory organ in the periphery, and hair cells are its main sensory cells. The development and survival of hair cells are highly controlled processes.
Ying Xiao, Dan Li
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Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

eLife, 2023
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi, Marielle O Beaulieu, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil, J Gage Crump, David W Raible   +7 more
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Exosomes mediate sensory hair cell protection in the inner ear.

Journal of Clinical Investigation, 2020
Hair cells are the mechanosensory receptors of the inner ear, responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely-used aminoglycoside antibiotics ...
Andrew M. Breglio, Lindsey A. May, M. Barzik, Nora Welsh, Shimon P. Francis, Tucker Costain, Lizheng Wang, D. Eric Anderson, Ronald S. Petralia, Ya‐Xian Wang, Thomas B. Friedman, Matthew J.A. Wood, Lisa L. Cunningham   +12 more
semanticscholar   +1 more source

Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear

Frontiers in Cell and Developmental Biology, 2021
Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding of ...
Shaoyuan Zhu, Shaoyuan Zhu, Zongwei Chen, Zongwei Chen, Haoming Wang, Haoming Wang, Brian M. McDermott, Brian M. McDermott, Brian M. McDermott, Brian M. McDermott   +9 more
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Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Frontiers in Ecology and Evolution, 2022
IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer, Kara E. Yopak, Craig A. Radford   +2 more
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Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
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Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model

Frontiers in Cellular Neuroscience, 2020
Sensorineural hearing loss is a common disability often caused by the loss of sensory hair cells in the cochlea. Hair cell (HCs) regeneration has long been the main target for the development of novel therapeutics for sensorineural hearing loss.
Mami Matsunaga, Tomoko Kita, Ryosuke Yamamoto, Norio Yamamoto, Takayuki Okano, Koichi Omori, Satoko Sakamoto, Takayuki Nakagawa   +7 more
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Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase

Scientific Reports, 2021
Hair follicles (HFs) are unique, multi-compartment, mini-organs that cycle through phases of active hair growth and pigmentation (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen).
Katarzyna Figlak, Greg Williams, Marta Bertolini, Ralf Paus, Michael P. Philpott   +4 more
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GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

Scientific Reports, 2022
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result, as ...
Hsin-I Jen, Sunita Singh, Litao Tao, Helen R. Maunsell, Neil Segil, Andrew K. Groves   +5 more
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A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs

Frontiers in Neuroscience, 2021
Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini, Basile Tarchini, Basile Tarchini   +2 more
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