Results 11 to 20 of about 11,093,699 (378)

Hair cell regeneration [PDF]

Current Opinion in Neurobiology, 2008
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Zheng-Yi Chen, Zheng-Yi Chen, Albert S.B. Edge   +2 more
openaire   +3 more sources

Exosomes mediate sensory hair cell protection in the inner ear.

Journal of Clinical Investigation, 2020
Hair cells are the mechanosensory receptors of the inner ear, responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely-used aminoglycoside antibiotics ...
Andrew M. Breglio, Lindsey A. May, M. Barzik, Nora Welsh, Shimon P. Francis, Tucker Costain, Lizheng Wang, D. Eric Anderson, Ronald S. Petralia, Ya‐Xian Wang, Thomas B. Friedman, Matthew J.A. Wood, Lisa L. Cunningham   +12 more
semanticscholar   +1 more source

Hair Follicle Stem Cells [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2003
The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle.
Lavker, Robert M, Sun, Tung-Tien, Oshima, Hideo, Barrandon, Yann, Akiyama, Masashi, Ferraris, Corinne, Chevalier, Genevieve, Favier, Bertrand, Jahoda, Colin a B, Dhouailly, Danielle, Panteleyev, Andrei A, Christiano, Angela M   +11 more
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Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear

Frontiers in Cell and Developmental Biology, 2021
Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding of ...
Shaoyuan Zhu, Shaoyuan Zhu, Zongwei Chen, Zongwei Chen, Haoming Wang, Haoming Wang, Brian M. McDermott, Brian M. McDermott, Brian M. McDermott, Brian M. McDermott   +9 more
doaj   +1 more source

Myosin and Adaptation by Hair Cells [PDF]

Neuron, 1997
Conclusive identification of the adaptation motor is not entirely academic. For example, a rational approach to identifying other members of the transduction apparatus is first to identify one component—the adaptation motor seems most likely—and then to identify interacting proteins using biochemical and molecular biological methods.
Peter G. Gillespie, David P. Corey
openaire   +3 more sources

Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Frontiers in Ecology and Evolution, 2022
IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer, Kara E. Yopak, Craig A. Radford   +2 more
doaj   +1 more source

The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack [PDF]

Microarrays, 2013
Mature mammals exhibit very limited capacity for regeneration of auditory hair cells, while all non-mammalian vertebrates examined can regenerate them. In an effort to find therapeutic targets for deafness and balance disorders, scientists have examined gene expression patterns in auditory tissues under different developmental and experimental ...
Michael E. Smith, Gopinath Rajadinakaran
openaire   +3 more sources

Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model

Frontiers in Cellular Neuroscience, 2020
Sensorineural hearing loss is a common disability often caused by the loss of sensory hair cells in the cochlea. Hair cell (HCs) regeneration has long been the main target for the development of novel therapeutics for sensorineural hearing loss.
Mami Matsunaga, Tomoko Kita, Ryosuke Yamamoto, Norio Yamamoto, Takayuki Okano, Koichi Omori, Satoko Sakamoto, Takayuki Nakagawa   +7 more
doaj   +1 more source

Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source

Beyond generalized hair cells: Molecular cues for hair cell types [PDF]

Hearing Research, 2013
Basic helix-loop-helix (bHLH) transcription factors (TFs) are crucial for inner ear neurosensory development. The proneural TF Atoh1 regulates the differentiation of hair cells (HCs) whereas Neurog1 and Neurod1 regulate specification and differentiation of neurons, respectively, but also affect HC development.
Israt Jahan, Bernd Fritzsch, Ning Pan, Jennifer Kersigo   +3 more
openaire   +3 more sources