Results 11 to 20 of about 209,439 (318)

Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear

Frontiers in Cell and Developmental Biology, 2021
Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding of ...
Shaoyuan Zhu, Shaoyuan Zhu, Zongwei Chen, Zongwei Chen, Haoming Wang, Haoming Wang, Brian M. McDermott, Brian M. McDermott, Brian M. McDermott, Brian M. McDermott   +9 more
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Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Frontiers in Ecology and Evolution, 2022
IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer, Kara E. Yopak, Craig A. Radford   +2 more
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Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model

Frontiers in Cellular Neuroscience, 2020
Sensorineural hearing loss is a common disability often caused by the loss of sensory hair cells in the cochlea. Hair cell (HCs) regeneration has long been the main target for the development of novel therapeutics for sensorineural hearing loss.
Mami Matsunaga, Tomoko Kita, Ryosuke Yamamoto, Norio Yamamoto, Takayuki Okano, Koichi Omori, Satoko Sakamoto, Takayuki Nakagawa   +7 more
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Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase

Scientific Reports, 2021
Hair follicles (HFs) are unique, multi-compartment, mini-organs that cycle through phases of active hair growth and pigmentation (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen).
Katarzyna Figlak, Greg Williams, Marta Bertolini, Ralf Paus, Michael P. Philpott   +4 more
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Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source

Beyond generalized hair cells: Molecular cues for hair cell types [PDF]

Hearing Research, 2013
Basic helix-loop-helix (bHLH) transcription factors (TFs) are crucial for inner ear neurosensory development. The proneural TF Atoh1 regulates the differentiation of hair cells (HCs) whereas Neurog1 and Neurod1 regulate specification and differentiation of neurons, respectively, but also affect HC development.
Israt Jahan, Bernd Fritzsch, Ning Pan, Jennifer Kersigo   +3 more
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GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

Scientific Reports, 2022
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result, as ...
Hsin-I Jen, Sunita Singh, Litao Tao, Helen R. Maunsell, Neil Segil, Andrew K. Groves   +5 more
doaj   +1 more source

Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells

Frontiers in Cellular Neuroscience, 2021
Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer, Amrita A. Iyer, Andrew K. Groves, Andrew K. Groves, Andrew K. Groves   +4 more
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Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium

iScience, 2023
Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga, Ryosuke Yamamoto, Tomoko Kita, Hiroe Ohnishi, Norio Yamamoto, Takayuki Okano, Koichi Omori, Takayuki Nakagawa   +7 more
doaj   +1 more source

Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag

Frontiers in Cell and Developmental Biology, 2018
The zebrafish inner ear organs and lateral line neuromasts are comprised of a variety of cell types, including mechanosensitive hair cells. Zebrafish hair cells are evolutionarily homologous to mammalian hair cells, and have been particularly useful for ...
Maggie S. Matern, Alisha Beirl, Yoko Ogawa, Yang Song, Nikhil Paladugu, Katie S. Kindt, Ronna Hertzano, Ronna Hertzano, Ronna Hertzano   +8 more
doaj   +1 more source