Results 21 to 30 of about 209,439 (318)
Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]
PLoS ONE, 2014 To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke +7 more
doaj +1 more source
Survival of auditory hair cells [PDF]
Cell and Tissue Research, 2015 The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L. Seymour, Fred A. Pereira
openaire +3 more sources
Keratin-mediated hair growth and its underlying biological mechanism
Communications Biology, 2022 Injecting human hair-derived keratin into mice skin accelerates hair growth & formation, as TGFβ2 secretion during hair destruction stimulates epithelial cell death and keratin release, leading to dermal cell condensation & hair growth.
Seong Yeong An +10 more
doaj +1 more source
Olfactory receptor OR2AT4 regulates human hair growth
Nature Communications, 2018 Increasing evidence suggest that olfactory receptors can carry additional functions besides olfaction. Here, Chéret et al. show that stimulation of the olfactory receptor ORT2A4 by the odorant Sandalore® stimulates growth of human scalp hair follicles ex
Jérémy Chéret +7 more
doaj +1 more source
A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
doaj +1 more source
Hair Cell Generator Potentials [PDF]
The Journal of General Physiology, 1973 A technique is introduced using a piezoelectric device to stimulate hair cells of a molluscan statocyst while recording their responses intracellularly. Statocyst displacements produced with the technique are calibrated with stroboscopic photography. Properties of the hair cells' response to currents and mechanical stimulation are studied.
Daniel L. Alkon, Anthony F. Bak
openaire +3 more sources
Magnetic actuation of hair cells [PDF]
Applied Physics Letters, 2011 The bullfrog sacculus contains mechanically sensitive hair cells whose stereociliary bundles oscillate spontaneously when decoupled from the overlying membrane. Steady-state offsets on the resting position of a hair bundle can suppress or modulate this native motility.
Jae Hyun Lee +4 more
openaire +3 more sources
Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish
Frontiers in Cell and Developmental Biology, 2018 Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells.
Katie S. Kindt, Lavinia Sheets
doaj +1 more source
Outer Hair Cells and Electromotility [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy into the cochlear partition and determine the overall mechanics of hearing. They do this by generating voltage-dependent axial forces. The resulting change in the cell length, observed by microscopy, has been termed "electromotility." The mechanism of force ...
openaire +4 more sources
Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1 [PDF]
Nature, 2018 The mammalian cochlea contains two types of mechanosensory hair cell that have different and critical functions in hearing. Inner hair cells (IHCs), which have an elaborate presynaptic apparatus, signal to cochlear neurons and communicate sound information to the brain.
Wiwatpanit, Teerawat +10 more
openaire +5 more sources