Results 211 to 220 of about 5,738,873 (283)

GSK3 Inhibition During Annelid Head Regeneration Results in a Hyper‐Proliferative Blastema and Impaired Differentiation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
A whole‐body regenerative annelid was treated with a GSK3 inhibitor. While posterior regeneration was mostly normal, GSK3 inhibition prevented differentiation of anterior‐specific structures and instead produced a persistent, oversized, hyper‐proliferative blastema. This suggests that GSK3 promotes anterior identity and halts proliferation during axial
James D. Nowotny, Eduardo E. Zattara, Maria Balarezo, Kevin G. Nyberg, Kenna M. Costello, Alexandra E. Bely   +5 more
wiley   +1 more source

Combinatorial Atoh1, Gfi1, Pou4f3, and Six1 gene transfer induces hair cell regeneration in the flat epithelium of mature guinea pigs. [PDF]

Hear Res
Liu Y, Yang L, Singh S, Beyer LA, Prieskorn DM, Swiderski DL, Groves AK, Raphael Y.   +7 more
europepmc   +1 more source

Smoking effects on root coverage outcomes between 3 and 12 months: A prospective cohort study

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the impact of smoking on root coverage outcomes, comparing healing responses at 3–12 months following coronally advanced flap with a connective tissue graft (CAF+CTG). Methods This prospective cohort study included 27 participants (13 smokers, 14 non‐smokers) who required root coverage for a single Cairo
Hande Has‐Elci, Duygu Taş, Zeliha Güney, Merve Atak, Sivge Kurgan, Muhittin A. Serdar, Dimitris N. Tatakis   +6 more
wiley   +1 more source

Impact of abrasive versus non‐abrasive cleaning on peri‐implantitis titanium release: A randomized clinical trial

Journal of Periodontology, EarlyView.
Abstract Background Surface decontamination is integral to peri‐implantitis treatment. However, abrasive mechanical methods can cause implant surface degradation with possible adverse biological effects. No human studies have examined whether these treatments cause titanium release or impair regenerative outcomes.
Georgios A. Kotsakis, Antonella Botto, Marzieh S. Jazaeri, Archontia Palaiologou, Eddie Lee, Diane M. Daubert   +5 more
wiley   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice. [PDF]

J Neurosci, 2020
Rudolf MA, Andreeva A, Kozlowski MM, Kim CE, Moskowitz BA, Anaya-Rocha A, Kelley MW, Corwin JT.   +7 more
europepmc   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

National Materials, EarlyView.
In this study, we engineered an antibacterial, antioxidative and epidermal grow factor‐encapsulated multifunctional hydrogel for the repair of chronic and refractory wounds. The hydrogel markedly promoted wound healing in rat models of diabetic foot ulcers and infected wounds by modulating wound microenvironment.
Zheng Zou, Yang Gao, Desheng Qi, Zhen Zhang, Chaoliang He, Xuesi Chen   +5 more
wiley   +1 more source