Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation [PDF]
Nature Communications, 2018 Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns +12 more
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Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss [PDF]
Cell Death and Disease, 2022 The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels +4 more
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Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells. [PDF]
PLoS ONE, 2012 The structural homeostasis of the cochlear hair cell membrane is critical for all aspects of sensory transduction, but the regulation of its maintenance is not well understood.
Guang-Jie Zhu +12 more
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Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea [PDF]
Journal of Neuroscience, 2017 open9siMutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans.
Stuart L. Johnson +8 more
core +2 more sources
Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure [PDF]
Scientific Reports, 2017 Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels +4 more
doaj +2 more sources
Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses [PDF]
Frontiers in Systems Neuroscience, 2014 The organ of Corti, the mammalian sensory epithelium of the inner ear, has two types of mechanoreceptor cells, inner hair cells (IHCs) and outer hair cells (OHCs).
Eleonora eKatz +3 more
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Defects in hair cells disrupt the development of auditory peripheral circuitry [PDF]
Nature CommunicationsDeafness is the most common form of sensory impairment in humans and frequently caused by defects in hair cells of the inner ear. Here we demonstrate that in male mice which model recessive non-syndromic deafness (DFNB6), inactivation of Tmie in hair ...
Riley T. Bottom +4 more
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells. [PDF]
, 2013 The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle.
Clemens Grisham, Rachel +4 more
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Frontiers in Ecology and Evolution, 2022 IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer +2 more
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