Results 1 to 10 of about 30,169 (168)

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome [PDF]

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +2 more sources

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature Communications, 2018
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti   +12 more
doaj   +2 more sources

Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function

Frontiers in Neuroscience, 2021
Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
doaj   +1 more source

Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Frontiers in Ecology and Evolution, 2022
IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer, Kara E. Yopak, Craig A. Radford   +2 more
doaj   +1 more source

Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells

Frontiers in Cellular Neuroscience, 2021
Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer, A. Groves
semanticscholar   +1 more source

An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure

Scientific Reports, 2021
Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion.
Jerome Nevoux, Mihaela Alexandru, Thomas Bellocq, Lei Tanaka, Yushi Hayashi, Takahisa Watabe, Hanae Lahlou, Kohsuke Tani, Albert S. B. Edge   +8 more
doaj   +1 more source

Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]

PLoS ONE, 2013
Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe, Huifang Sun, Kevin Wang, James D Asuncion, Qi Wang, Chien-Wei Chen, Peter S Steyger, Michael E Smith, Jonathan I Matsui   +8 more
doaj   +1 more source

Recent advancements in cell-based models for auditory disorders [PDF]

BioImpacts, 2022
Introduction: Cell-based models play an important role in understanding the pathophysiology and etiology of auditory disorders. For the auditory system, models have primarily focused on restoring inner and outer hair cells.
Jake Langlie, Ariel Finberg, Nathalie B. Bencie, Jeenu Mittal, Hossein Omidian, Yadollah Omidi, Rahul Mittal, Adrien A. Eshraghi   +7 more
doaj   +1 more source

Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss

Cell Death and Disease, 2022
The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels, Jun Wang, Anwen Bullen, Patricia M. White, Amy E. Kiernan   +4 more
doaj   +1 more source

Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model

Frontiers in Cellular Neuroscience, 2022
Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
doaj   +1 more source