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Approaches of auditory hair cells induction from stem cells [PDF]

Otorhinolaryngology and Facial Plastic Surgery, 2017
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat, Navid Ahmady Roozbahany, Somayeh Niknazar   +2 more
doaj   +2 more sources

Acbd7 is essential for preserving hair cell-mediated auditory and vestibular function. [PDF]

Exp Mol Med
Understanding the molecular basis of hair cell function is essential for elucidating inner ear physiology and developing therapies for auditory–vestibular disorders.
Wu M, Jia G, Jia Y, Huang Y, Li Y, Liu Y, Lou Y, Sun T, Qiu X, Xia M, Li H, Li W.   +11 more
europepmc   +2 more sources

Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction. [PDF]

Adv Sci (Weinh)
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Feng P, Zhu Q, Wang Y, Rong H, Zhang X, Wang F, Yu T, Wang W, Li J, Tian L, Liao M, Chai R, Hu Y.   +12 more
europepmc   +2 more sources

Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]

Cellular and Molecular Life Sciences, 2009
It has recently been shown that the oxygenregulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones. The receptors for Epo and VEGF are widely expressed in different organs. Since mammalian auditory hair cells can irreversibly be damaged by different agents,
Monge Naldi, Arianne, Gassmann, Max, Bodmer, Daniel   +2 more
openaire   +6 more sources

Myosin Light-Chain Kinase Is Necessary for Membrane Homeostasis in Cochlear Inner Hair Cells [PDF]

PLoS ONE, 2012
The structural homeostasis of the cochlear hair cell membrane is critical for all aspects of sensory transduction, but the regulation of its maintenance is not well understood.
Jian Zuo, Wei-Qi He, Min-Sheng Zhu
exaly   +2 more sources

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation [PDF]

Nature Communications, 2018
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti   +12 more
doaj   +2 more sources

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]

PLoS ONE, 2014
Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand, Vesna Radojevic, Michael Sung, Eric Wei, Cristian Setz, Andrea Glutz, Katharina Leitmeyer, Daniel Bodmer   +7 more
doaj   +6 more sources

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids

Stem Cell Reports, 2019
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Rick F Nelson, Pei-Ciao Tang, Karl R Koehler   +2 more
exaly   +3 more sources

Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function

Frontiers in Neuroscience, 2021
Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
doaj   +1 more source

Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Frontiers in Ecology and Evolution, 2022
IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer, Kara E. Yopak, Craig A. Radford   +2 more
doaj   +1 more source