Results 1 to 10 of about 110,300 (255)

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

eLife, 2015
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh network
Christine Petit, Philippe F.Y. Vincent, Didier Dulon, Didier Dulon, Yohan Bouleau   +4 more
openaire   +6 more sources

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature Communications, 2018
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti   +12 more
doaj   +2 more sources

Behavioral auditory thresholds and loss of ribbon synapses at inner hair cells in aged gerbils

Experimental Gerontology, 2016
The potential contribution of auditory synaptopathy to age dependent hearing loss was studied in groups of young and old gerbils. The analysis of the number of inner hair cell ribbon synapses in aged gerbils (37.9±3.3months of age) revealed only a relatively small (11-17%) loss in the basal two thirds of the cochlea, while a more pronounced reduction ...
Philipp R. O. Semmler, Otto Gleich, Jürgen Strutz   +2 more
openaire   +4 more sources

Defects in hair cells disrupt the development of auditory peripheral circuitry [PDF]

Nature Communications
Deafness is the most common form of sensory impairment in humans and frequently caused by defects in hair cells of the inner ear. Here we demonstrate that in male mice which model recessive non-syndromic deafness (DFNB6), inactivation of Tmie in hair ...
Riley T. Bottom, Yijun Xu, Caroline Siebald, Jinsei Jung, Ulrich Müller   +4 more
doaj   +2 more sources

Investigating the expression profiles of cysteine string proteins (CSPs) in cochlear tissue [PDF]

Journal of Otology
Objective: This study aims to explore the expression patterns of cysteine string protein alpha (CSPα) and cysteine string protein beta (CSPβ) in the mammalian inner ear, with an emphasis on their temporal dynamics during the developmental stages of C57BL/
Shili Zhang, Caiji Wang, Yuehua Qiao, Xi Shi   +3 more
doaj   +2 more sources

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]

PLoS ONE, 2014
Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand, Vesna Radojevic, Michael Sung, Eric Wei, Cristian Setz, Andrea Glutz, Katharina Leitmeyer, Daniel Bodmer   +7 more
doaj   +6 more sources

Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function

Frontiers in Neuroscience, 2021
Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
doaj   +1 more source

Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Frontiers in Ecology and Evolution, 2022
IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer, Kara E. Yopak, Craig A. Radford   +2 more
doaj   +1 more source

Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells

Frontiers in Cellular Neuroscience, 2021
Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer, A. Groves
semanticscholar   +1 more source

An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure

Scientific Reports, 2021
Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion.
Jerome Nevoux, Mihaela Alexandru, Thomas Bellocq, Lei Tanaka, Yushi Hayashi, Takahisa Watabe, Hanae Lahlou, Kohsuke Tani, Albert S. B. Edge   +8 more
doaj   +1 more source