Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure [PDF]
Scientific Reports, 2017 Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels +4 more
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Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells. [PDF]
PLoS ONE, 2012 The structural homeostasis of the cochlear hair cell membrane is critical for all aspects of sensory transduction, but the regulation of its maintenance is not well understood.
Guang-Jie Zhu +12 more
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Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
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Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids
Stem Cell Reports, 2019 Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang +8 more
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Frontiers in Ecology and Evolution, 2022 IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer +2 more
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An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
Scientific Reports, 2021 Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion.
Jerome Nevoux +8 more
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Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]
PLoS ONE, 2013 Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe +8 more
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Auditory hair cell precursors immortalized from the mammalian inner ear [PDF]
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1998 Mammalian auditory hair cells are few in number, experimentally inaccessible, and do not proliferate postnatally or in vitro. Immortal cell lines with the potential to differentiate into auditory hair cells would substantially facilitate auditory research, drug development, and the isolation of critical molecules involved in hair cell biology.
M N, Rivolta +5 more
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Recent advancements in cell-based models for auditory disorders [PDF]
BioImpacts, 2022 Introduction: Cell-based models play an important role in understanding the pathophysiology and etiology of auditory disorders. For the auditory system, models have primarily focused on restoring inner and outer hair cells.
Jake Langlie +7 more
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