Results 91 to 100 of about 15,322 (225)
Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids
Stem Cell Reports, 2019 Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang +8 more
doaj +1 more source
Antimicrobial prescribing guidelines for horses in Australia
Australian Veterinary Journal, EarlyView.The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt +18 more
wiley +1 more source
An efficient strategy for establishing a model of sensorineural deafness in rats
Neural Regeneration Research, 2015 Ototoxic drugs can be used to produce a loss of cochlear hair cells to create animal models of deafness. However, to the best of our knowledge, there is no report on the establishment of a rat deafness model through the combined application of ...
Long Ma +4 more
doaj +1 more source
Re‐make, re‐model: evolution and development of vertebrate cranial lateral lines
Biological Reviews, EarlyView.ABSTRACT Lateral lines are placodally derived mechanosensory systems on the heads and trunks of many aquatic vertebrates. There is evidence of lateral lines in the earliest known vertebrate fossils, and they exist in organisms with widely different craniofacial morphologies – including the presence or absence of jaws, external or internal nostrils, and
Vishruth Venkataraman +3 more
wiley +1 more source
Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells
Cell Proliferation, EarlyView.Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai +9 more
wiley +1 more source
PLoS Genetics, 2011 Cellular heterogeneity hinders the extraction of functionally significant results and inference of regulatory networks from wide-scale expression profiles of complex mammalian organs.
Ronna Hertzano +10 more
doaj +1 more source
Cell Proliferation, EarlyView.Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang +10 more
wiley +1 more source
Neural Plasticity, 2018 Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles ...
Shaofeng Liu +10 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2014 The organ of Corti, the mammalian sensory epithelium of the inner ear, has two types of mechanoreceptor cells, inner hair cells (IHCs) and outer hair cells (OHCs).
Eleonora eKatz +3 more
doaj +1 more source
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Cell Proliferation, EarlyView.Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng +4 more
wiley +1 more source