A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells
eLife, 2015 We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells.
P. F. Vincent +4 more
semanticscholar +6 more sources
Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]
Cellular and Molecular Life Sciences, 2018 It has recently been shown that the oxygen-regulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones.
Bodmer, Daniel +2 more
core +5 more sources
Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
doaj +6 more sources
Frontiers in Cellular Neuroscience, 2021 Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer, A. Groves
semanticscholar +1 more source
Mapping the regulatory landscape of auditory hair cells from single-cell multi-omics data
Genome Research, 2021 Auditory hair cells transduce sound to the brain, and in mammals, these cells reside together with supporting cells in the sensory epithelium of the cochlea, called the organ of Corti.
Shuze Wang +4 more
semanticscholar +1 more source
An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
Scientific Reports, 2021 Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion.
Jerome Nevoux +8 more
doaj +1 more source
Recent advancements in cell-based models for auditory disorders [PDF]
BioImpacts, 2022 Introduction: Cell-based models play an important role in understanding the pathophysiology and etiology of auditory disorders. For the auditory system, models have primarily focused on restoring inner and outer hair cells.
Jake Langlie +7 more
doaj +1 more source
Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]
PLoS ONE, 2013 Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe +8 more
doaj +1 more source
Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model
Frontiers in Cellular Neuroscience, 2022 Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
doaj +1 more source
Auditory hair cell precursors immortalized from the mammalian inner ear [PDF]
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1998 Mammalian auditory hair cells are few in number, experimentally inaccessible, and do not proliferate postnatally or in vitro. Immortal cell lines with the potential to differentiate into auditory hair cells would substantially facilitate auditory research, drug development, and the isolation of critical molecules involved in hair cell biology.
Daniel J. Jagger +5 more
openaire +2 more sources