Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]
Cellular and Molecular Life Sciences, 2018 It has recently been shown that the oxygen-regulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones.
Bodmer, Daniel +2 more
core +5 more sources
Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
doaj +5 more sources
Inner-Hair Cells Parameterized-Hardware Implementation for Personalized Auditory Nerve Stimulation [PDF]
, 2011 In this paper the hardware implementation of an inner hair cell model is presented. Main features of the design are the use of Meddis’ transduction structure and the methodology for Design with Reusability.
Ferrández Vicente, José Manuel +4 more
core +3 more sources
Auditory hair cell precursors immortalized from the mammalian inner ear [PDF]
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1998 Mammalian auditory hair cells are few in number, experimentally inaccessible, and do not proliferate postnatally or in vitro. Immortal cell lines with the potential to differentiate into auditory hair cells would substantially facilitate auditory research, drug development, and the isolation of critical molecules involved in hair cell biology.
M N, Rivolta +5 more
openaire +2 more sources
Research Progress on the Mechanism of Cochlear Hair Cell Regeneration
Frontiers in Cellular Neuroscience, 2021 Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
doaj +1 more source
Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System [PDF]
Journal of Neurophysiology, 2007 Auditory function in the mammalian inner ear is optimized by collaboration of two classes of sensory cells known as inner and outer hair cells. Outer hair cells amplify and tune sound stimuli that are transduced and transmitted by inner hair cells. Although they subserve distinct functions, they share a number of common properties. Here we compare the
Eric A, Stauffer, Jeffrey R, Holt
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Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells. [PDF]
PLoS ONE, 2012 The structural homeostasis of the cochlear hair cell membrane is critical for all aspects of sensory transduction, but the regulation of its maintenance is not well understood.
Guang-Jie Zhu +12 more
doaj +1 more source
Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells. [PDF]
, 2013 The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle.
Clemens Grisham, Rachel +4 more
core +6 more sources
Kölliker’s organ-supporting cells and cochlear auditory development
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
doaj +1 more source
Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
doaj +1 more source