Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]
Cellular and Molecular Life Sciences, 2009 It has recently been shown that the oxygen-regulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones. The receptors for Epo and VEGF are widely expressed in different organs.
Monge Naldi, Arianne +2 more
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Research Progress on the Mechanism of Cochlear Hair Cell Regeneration
Frontiers in Cellular Neuroscience, 2021 Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
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Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells. [PDF]
PLoS ONE, 2012 The structural homeostasis of the cochlear hair cell membrane is critical for all aspects of sensory transduction, but the regulation of its maintenance is not well understood.
Guang-Jie Zhu +12 more
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Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System [PDF]
Journal of Neurophysiology, 2007 Auditory function in the mammalian inner ear is optimized by collaboration of two classes of sensory cells known as inner and outer hair cells. Outer hair cells amplify and tune sound stimuli that are transduced and transmitted by inner hair cells. Although they subserve distinct functions, they share a number of common properties. Here we compare the
Jeffrey R. Holt, Eric A. Stauffer
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Kölliker’s organ-supporting cells and cochlear auditory development
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
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Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
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Parallel Distribution of an Inner Hair Cell and Auditory Nerve Model for Real-Time Application [PDF]
IEEE Transactions on Biomedical Circuits and Systems, 2017 This paper summarizes recent efforts in implementing a model of the ear's inner hair cell and auditory nerve on a neuromorphic hardware platform, the SpiNNaker machine. This exploits the massive parallelism of the target architecture to obtain real-time modeling of a biologically realistic number of human auditory nerve fibres.
Robert James +6 more
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Development of otic organoids and their current status [PDF]
Organoid, 2023 The inner ear is responsible for both hearing and balance in the body, and since the initial development of otic (inner ear) organoids from mouse pluripotent stem cells (PSCs) in 2013, significant advances have been made in this field. Bone morphogenetic
Hantai Kim +9 more
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Remodeling of the Inner Hair Cell Microtubule Meshwork in a Mouse Model of Auditory Neuropathy AUNA1 [PDF]
eneuro, 2016 AbstractAuditory neuropathy 1 (AUNA1) is a form of human deafness resulting from a point mutation in the 5′ untranslated region of theDiaphanous homolog 3(DIAPH3) gene. Notably, theDIAPH3mutation leads to the overexpression of the DIAPH3 protein, a formin family member involved in cytoskeleton dynamics. Through study of diap3-overexpressing transgenic (
Surel, Clément +9 more
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Rat Auditory Inner Hair Cell Mechanotransduction and Stereociliary Membrane Diffusivity Are Similarly Modulated by Calcium [PDF]
iScience, 2020 The lipid bilayer plays a pivotal role in force transmission to many mechanically-gated channels. We developed the technology to monitor membrane diffusivity in order to test the hypothesis positing that Ca2+ regulates open probability (P o) of cochlear hair cell mechanotransduction (MET) channels via the plasma membrane. The stereociliary membrane was
Shefin S. George +2 more
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