Results 51 to 60 of about 50,414 (231)

A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells

Cell Discovery, 2019
Dear Editor, F-actin is expressed in almost all cells, and plays a variety of important roles. In the cuticular plate of hair cells, they are thought to be critical in mammalian hearing by holding the stereocilia rootlets in place and providing the ...
J. Qi, Yan Liu, Cenfeng Chu, Xin Chen, Weijie Zhu, Y. Shu, Shuijin He, R. Chai, Guisheng Zhong   +8 more
semanticscholar   +1 more source

Differences in auditory nerve fiber responses in regard to inner and outer hair cells [PDF]

The Journal of the Acoustical Society of America, 1978
Single unit recordings were made from auditory nerve fibers in the monkey to pure tone stimuli. Extensive studies of frequency response areas suggested the existence of two types of auditory nerve fibers. One type showed a flat-bottomed response area and the other showed a conventional sharp one.
M. Nomoto, M. Maekawa
openaire   +2 more sources

Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

Frontiers in Cell and Developmental Biology, 2020
Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in
Prathamesh T. Nadar-Ponniah, Prathamesh T. Nadar-Ponniah, Shahar Taiber, Michal Caspi, Tal Koffler-Brill, Amiel A. Dror, Amiel A. Dror, Ronen Siman-Tov, Moran Rubinstein, Moran Rubinstein, Krishnanand Padmanabhan, Chen Luxenburg, Richard A. Lang, Karen B. Avraham, Rina Rosin-Arbesfeld   +14 more
doaj   +1 more source

Protective effect of astaxanthin nanoemulsion on mammalian inner ear hair cells [PDF]

PeerJ, 2023
Background Aminoglycoside antibiotics are used for treating certain acute infections. However, these drugs cause ototoxicity by inducing inner ear hair cell death.
Yuki Kobayashi, Kazuma Sugahara, Yosuke Takemoto, Junko Tsuda, Yoshinobu Hirose, Makoto Hashimoto, Hiroshi Yamashita   +6 more
doaj   +2 more sources

Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice

Journal of Neuroscience, 2019
Transmitter release at auditory inner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergic vesicles during voltage activation of L-type Cav1.3 calcium channels. At these synapses, the fast and indefatigable release of synaptic vesicles by
Margot Tertrais, Yohan Bouleau, Alice Emptoz, S. Belleudy, R B Sutton, C. Petit, S. Safieddine, D. Dulon   +7 more
semanticscholar   +1 more source

A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs

Frontiers in Neuroscience, 2021
Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini, Basile Tarchini, Basile Tarchini   +2 more
doaj   +1 more source

Effects of sound-induced hearing loss and hearing AIDS on the perception of music [PDF]

, 2016
This is the final version of the article. It first appeared from the Audio Engineering Society via https://doi.org/10.17743/jaes.2015.0081Exposure to high-level music produces several physiological changes in the auditory system that lead to a variety of
Moore, BCJ
core   +1 more source

LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Hair cells of the cochlea transduce mechanical energy into electrical signals. Acoustic stimulation of mechanotransduction channels generates a graded receptor potential that elicits glutamate release from hair cells onto postsynaptic ...
C. Lingle, P. L. Martinez-Espinosa, Aizhen Yang-Hood, Luis E. Boero, Shelby Payne, Dora Persic, Babak V-Ghaffari, Maolei Xiao, Yu Zhou, X. Xia, S. Pyott, M. Rutherford   +11 more
semanticscholar   +1 more source

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea

Journal of Physiology, 2019
The physiological maturation of auditory hair cells and their innervation requires precise temporal and spatial control of cell differentiation. The transcription factor gata3 is essential for the earliest stages of auditory system development and for ...
Tanaya Bardhan, J. Jeng, Marco Waldmann, F. Ceriani, Stuart L. Johnson, J. Olt, L. Rüttiger, W. Marcotti, M. Holley   +8 more
semanticscholar   +1 more source

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +1 more source