Results 51 to 60 of about 37,354 (236)

Evaluation of inner hair cell and nerve fiber loss as sufficient pathologies underlying auditory neuropathy [PDF]

Hearing Research, 2009
Auditory neuropathy is a hearing disorder characterized by normal function of outer hair cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions (OAEs), with absent or severely dys-synchronized auditory brainstem responses (ABRs).
Mohamed M, El-Badry, Sandra L, McFadden
openaire   +2 more sources

Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

Frontiers in Cellular Neuroscience, 2018
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus, Jean-Charles Ceccato, Gaston Sendin, Jérôme Bourien, Jean-Luc Puel, Régis Nouvian   +5 more
doaj   +1 more source

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature Communications, 2018
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti   +12 more
doaj   +1 more source

Behavioral auditory thresholds and loss of ribbon synapses at inner hair cells in aged gerbils

Experimental Gerontology, 2016
The potential contribution of auditory synaptopathy to age dependent hearing loss was studied in groups of young and old gerbils. The analysis of the number of inner hair cell ribbon synapses in aged gerbils (37.9±3.3months of age) revealed only a relatively small (11-17%) loss in the basal two thirds of the cochlea, while a more pronounced reduction ...
Otto, Gleich, Philipp, Semmler, Jürgen, Strutz   +2 more
openaire   +2 more sources

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

Neural Plasticity, 2018
Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced ...
Muhammad Waqas, Song Gao, Iram-us-Salam, Muhammad Kazim Ali, Yongming Ma, Wenyan Li   +5 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice

Frontiers in Cellular Neuroscience, 2021
Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their cellular and physiological pathology in cochlea has rarely been investigated in vivo.
Pengcheng Xu, Pengcheng Xu, Pengcheng Xu, Longhao Wang, Longhao Wang, Longhao Wang, Hu Peng, Huihui Liu, Huihui Liu, Huihui Liu, Hongchao Liu, Hongchao Liu, Hongchao Liu, Qingyue Yuan, Qingyue Yuan, Qingyue Yuan, Yun Lin, Yun Lin, Yun Lin, Jun Xu, Jun Xu, Jun Xu, Xiuhong Pang, Hao Wu, Hao Wu, Hao Wu, Tao Yang, Tao Yang, Tao Yang   +28 more
doaj   +1 more source

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]

, 2017
We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo, Chiorini, John A., Crispino, Giulia, Di Pasquale, Giovanni, Galindo Ramirez, Fabian, Mammano, Fabio, Praetorius, Mark, Zorzi, Veronica   +7 more
core   +1 more source

PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

Neural Regeneration Research, 2023
Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.
Bei Fan, Fei Lu, Wei-Jia Du, Jun Chen, Xiao-Gang An, Ren-Feng Wang, Wei Li, Yong-Li Song, Ding-Jun Zha, Fu-Quan Chen   +9 more
doaj   +1 more source

Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays

Advanced Science, EarlyView.
This study introduces a behavioral paradigm for memory updating and reveals underlying hippocampal mechanisms. Replays of place cells predict future behavioral choices during behavior and show a bias toward high‐reward locations during non‐rapid eye movement (NREM) sleep, specifically within the memory updating process.
Jifu Tong, Yuanwei Xing, Yawen Zheng, Linshu Wang, Shan Shao, Jiao Wu, Longyu Ma, Shuting Liu, Naizheng Liu, Xuetao Qi, Ting Wang, Kun Cui, Shuang Cui, You Wan, Ming Yi   +14 more
wiley   +1 more source