Results 51 to 60 of about 50,821 (291)

Differences in auditory nerve fiber responses in regard to inner and outer hair cells [PDF]

The Journal of the Acoustical Society of America, 1978
Single unit recordings were made from auditory nerve fibers in the monkey to pure tone stimuli. Extensive studies of frequency response areas suggested the existence of two types of auditory nerve fibers. One type showed a flat-bottomed response area and the other showed a conventional sharp one.
M. Nomoto, M. Maekawa
openaire   +2 more sources

Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

Frontiers in Cell and Developmental Biology, 2020
Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in
Prathamesh T. Nadar-Ponniah, Prathamesh T. Nadar-Ponniah, Shahar Taiber, Michal Caspi, Tal Koffler-Brill, Amiel A. Dror, Amiel A. Dror, Ronen Siman-Tov, Moran Rubinstein, Moran Rubinstein, Krishnanand Padmanabhan, Chen Luxenburg, Richard A. Lang, Karen B. Avraham, Rina Rosin-Arbesfeld   +14 more
doaj   +1 more source

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]

, 2017
We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo, Chiorini, John A., Crispino, Giulia, Di Pasquale, Giovanni, Galindo Ramirez, Fabian, Mammano, Fabio, Praetorius, Mark, Zorzi, Veronica   +7 more
core   +1 more source

Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. [PDF]

, 2017
In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic structure-the synaptic ribbon-that organizes both synaptic vesicles ...
Beirl, A., He, X.J., Kindt, K.S., Marcotti, W., Nicolson, T., Olt, J., Petralia, R.S., Schreck, M., Sheets, L., Trapani, J.G., Wang, Y-X., Zhang, Q.   +11 more
core   +1 more source

LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Hair cells of the cochlea transduce mechanical energy into electrical signals. Acoustic stimulation of mechanotransduction channels generates a graded receptor potential that elicits glutamate release from hair cells onto postsynaptic ...
C. Lingle, P. L. Martinez-Espinosa, Aizhen Yang-Hood, Luis E. Boero, Shelby Payne, Dora Persic, Babak V-Ghaffari, Maolei Xiao, Yu Zhou, X. Xia, S. Pyott, M. Rutherford   +11 more
semanticscholar   +1 more source

A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs

Frontiers in Neuroscience, 2021
Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini, Basile Tarchini, Basile Tarchini   +2 more
doaj   +1 more source

A novel ENU-induced mutation in Myo6 causes vestibular dysfunction and deafness [PDF]

, 2016
Mouse N-ethyl-N-nitrosourea (ENU) mutagenesis has generated many useful animal models for human diseases. Here we describe the identification of a novel ENU-induced mouse mutant strain Turner (Tur) that displays circling and headtossing behavior and ...
Brahmachary, M, Wong, YME, Xu, CY, Xu, PX   +3 more
core   +1 more source

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea

Journal of Physiology, 2019
The physiological maturation of auditory hair cells and their innervation requires precise temporal and spatial control of cell differentiation. The transcription factor gata3 is essential for the earliest stages of auditory system development and for ...
Tanaya Bardhan, J. Jeng, Marco Waldmann, F. Ceriani, Stuart L. Johnson, J. Olt, L. Rüttiger, W. Marcotti, M. Holley   +8 more
semanticscholar   +1 more source

The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles [PDF]

, 2006
Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links.
Birch, David G, Goodyear, Richard J, Holt, Jeffrey R, Legan, P Kevin, Locke, Kirsten G, McGee, JoAnn, McMillan, D Randy, Richardson, Guy P, Stauffer, Eric A, Walsh, Edward J, White, Perrin C   +10 more
core   +1 more source

Localization of TMC1 and LHFPL5 in auditory hair cells in neonatal and adult mice

The FASEB Journal, 2019
The channel that governs mechanotransduction (MT) by hair cells in the inner ear has been investigated intensively for 4 decades, but its precise molecular composition remains enigmatic. Transmembrane channel‐like protein 1 (TMC1) was recently identified
Xiaofen Li, Xiaojie Yu, Xibing Chen, Zhengzhao Liu, Guangqin Wang, Chao Li, E. Wong, M. Sham, Jie Tang, Jufang He, Wei Xiong, Zhiyong Liu, Pingbo Huang   +12 more
semanticscholar   +1 more source