Results 51 to 60 of about 37,698 (205)

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +1 more source

A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs

Frontiers in Neuroscience, 2021
Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini, Basile Tarchini, Basile Tarchini   +2 more
doaj   +1 more source

Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]

, 2013
Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G., Avallone, B., Di Bonito, M., Franze, A. M., Mancuso, M., Narita, Y., Puelles, L., Rijli, F. M., Sequino, L., Studer, M.   +9 more
core   +5 more sources

Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

Frontiers in Cellular Neuroscience, 2018
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus, Jean-Charles Ceccato, Gaston Sendin, Jérôme Bourien, Jean-Luc Puel, Régis Nouvian   +5 more
doaj   +1 more source

Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice

Frontiers in Cellular Neuroscience, 2021
Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their cellular and physiological pathology in cochlea has rarely been investigated in vivo.
Pengcheng Xu, Pengcheng Xu, Pengcheng Xu, Longhao Wang, Longhao Wang, Longhao Wang, Hu Peng, Huihui Liu, Huihui Liu, Huihui Liu, Hongchao Liu, Hongchao Liu, Hongchao Liu, Qingyue Yuan, Qingyue Yuan, Qingyue Yuan, Yun Lin, Yun Lin, Yun Lin, Jun Xu, Jun Xu, Jun Xu, Xiuhong Pang, Hao Wu, Hao Wu, Hao Wu, Tao Yang, Tao Yang, Tao Yang   +28 more
doaj   +1 more source

Mammalian cochlea as a physics guided evolution-optimized hearing sensor [PDF]

, 2014
Nonlinear physics plays an essential role in hearing, from sound signal generation to sound sensing to the processing of complex sound environments. We demonstrate that the evolution of the biological hearing sensors demonstrates a dramatic reduction in ...
Gomez, Florian, Lorimer, Tom, Stoop, Ruedi   +2 more
core   +2 more sources

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. [PDF]

, 2015
The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear.
Cederholm, Jennie ME, Froud, Kristina E, Housley, Gary D, Julien, Jean-Pierre, Klugmann, Matthias, Ryan, Allen F, Sandow, Shaun L, Wong, Ann Chi Yan   +7 more
core   +2 more sources

Behavioral auditory thresholds and loss of ribbon synapses at inner hair cells in aged gerbils

Experimental Gerontology, 2016
The potential contribution of auditory synaptopathy to age dependent hearing loss was studied in groups of young and old gerbils. The analysis of the number of inner hair cell ribbon synapses in aged gerbils (37.9±3.3months of age) revealed only a relatively small (11-17%) loss in the basal two thirds of the cochlea, while a more pronounced reduction ...
Otto, Gleich, Philipp, Semmler, Jürgen, Strutz   +2 more
openaire   +2 more sources

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

Neural Plasticity, 2018
Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced ...
Muhammad Waqas, Song Gao, Iram-us-Salam, Muhammad Kazim Ali, Yongming Ma, Wenyan Li   +5 more
doaj   +1 more source

A novel ENU-induced mutation in Myo6 causes vestibular dysfunction and deafness [PDF]

, 2016
Mouse N-ethyl-N-nitrosourea (ENU) mutagenesis has generated many useful animal models for human diseases. Here we describe the identification of a novel ENU-induced mouse mutant strain Turner (Tur) that displays circling and headtossing behavior and ...
Brahmachary, M, Wong, YME, Xu, CY, Xu, PX   +3 more
core   +1 more source