Results 81 to 90 of about 463,740 (300)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity [PDF]

, 2019
Aminoglycoside (AG) antibiotics are widely used to prevent life-threatening infections, and cisplatin is used in the treatment of various cancers, but both are ototoxic and result in loss of sensory hair cells from the inner ear.
Camci, Esra D, Gibson, Robin M, Kirkwood, Nerissa K, Kitcher, Siân R, Kros, Corné J, Ogelman, Roberto, Raible, David W, Redila, Van A, Richardson, Guy P, Rubel, Edwin W, Simon, Julian A, Wu, Patricia   +11 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids

Cell Reports
Summary: Human pluripotent stem cell-derived cochlear organoids are promising tools for studying human cochlear development and disease. However, the maturation of hair cells in these organoids is slow, requiring 200 days to express the mature outer hair
Tsubasa Saeki, Yoshitomo Ueda, Isabel Aristizábal-Ramírez, Stephen T. Moore, Rick F. Nelson, Gregory I. Frolenkov, Eri Hashino   +6 more
doaj   +1 more source

scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

eLife, 2019
Loss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized support cells.
Mark E Lush, Daniel C Diaz, Nina Koenecke, Sungmin Baek, Helena Boldt, Madeleine K St Peter, Tatiana Gaitan-Escudero, Andres Romero-Carvajal, Elisabeth M Busch-Nentwich, Anoja G Perera, Kathryn E Hall, Allison Peak, Jeffrey S Haug, Tatjana Piotrowski   +13 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Approaches of auditory hair cells induction from stem cells

Otorhinolaryngology and Facial Plastic Surgery, 2017
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat, Navid Ahmady Roozbahany, Somayeh Niknazar   +2 more
doaj   +1 more source

Neural Potential of a Stem Cell Population in the Hair Follicle [PDF]

, 2007
The bulge region of the hair follicle serves as a repository for epithelial stem cells that can regenerate the follicle in each hair growth cycle and contribute to epidermis regeneration upon injury.
Enikolopov, G. N., Fedtsova, N., Gleiberman, A., Keyes, W. M., Maletic-Savatic, M., Manganas, L. N., Mignone, J. L., Mills, A. A., Roig-Lopez, J. L., Schones, D. E., Zhang, M. Q.   +10 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea

Biology Open, 2016
Loss of sensory hair cells of the inner ear due to aminoglycoside exposure is a major cause of hearing loss. Using an immortalized multipotent otic progenitor (iMOP) cell line, specific signaling pathways that promote otic cell survival were identified ...
Azadeh Jadali, Kelvin Y. Kwan
doaj   +1 more source