Results 1 to 10 of about 11,321 (127)

Hyaluronic acid synthase 2 dysfunction exacerbates elastase-induced neutrophilic airway inflammation and emphysema in mice [PDF]

Frontiers in Immunology
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder primarily caused by prolonged exposure to harmful substances, such as cigarette smoke. Hyaluronic acid synthase 2 (HAS2) synthesizes high-molecular-weight hyaluronic
Kengo Nishino, Takumi Kiwamoto, Masashi Matsuyama, Zhenting Wei, Sosuke Matsumura, Kenya Kuramoto, Yuki Yabuuchi, Kai Yazaki, Kazufumi Yoshida, Yosuke Matsuno, Yuko Morishima, Nobuyuki Hizawa   +11 more
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Fibroblast Has2 limits acute heart failure following myocardial infarction in male mice [PDF]

Physiological Reports
Changes to the extracellular matrix support acute wound healing following myocardial infarction. Fibroblasts regulate the composition of the extracellular matrix, in part, by secreting hyaluronan. Details surrounding the regulation, source, and impact of
Danielle T. Little, Kenneth R. Brittian, Caitlin Howard, Emma Pendergraft, Casey Colley, Ning Chen, Yu Yamaguchi, Richa Singhal, Joseph B. Moore IV, Marcin Wysoczynski, Yibing Nong, Steven P. Jones   +11 more
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Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway [PDF]

Neural Regeneration Research
Peripheral nerve defect repair is a complex process that involves multiple cell types; perineurial cells play a pivotal role. Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling; however ...
Yiming Huo, Bing Xiao, Haojie Yu, Yang Xu, Jiachen Zheng, Chao Huang, Ling Wang, Haiyan Lin, Jiajun Xu, Pengfei Yang, Fang Liu   +10 more
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Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]

Biomedicines
Hyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny S. K. Chan, Kevin W.-H. Lo   +10 more
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Prognostic value of a combination of cardiac biomarkers and risk indices for major adverse cardiovascular events following non-cardiac surgery in geriatric patients: a prospective cohort study [PDF]

Scientific Reports
Major adverse cardiovascular events (MACEs) in geriatric patients are an important cause of increased mortality and morbidity. The results of current studies regarding the predictive value of the NT-proBNP, H-FABP, and AUB-HAS2 scales for cardiovascular ...
Xialian Hu, Yi Zhao, Mengchan Ou, Tao Zhu, Xuechao Hao   +4 more
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Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing [PDF]

Frontiers in Molecular Neuroscience
IntroductionIntervertebral disc degeneration (IVDD) and non-alcoholic fatty liver disease (NAFLD) represent major global health burdens. Although recent evidence points to a potential association between these two conditions, the underlying molecular ...
Jiasen Wei, Jiasen Wei, Chenglong Ji, Lina Liu, Chen Yan, Linhui Han, Wenbo Lin, Ximing Xu, Kaiqiang Sun, Kaiqiang Sun   +9 more
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Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice [PDF]

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
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Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy [PDF]

Natural Products and Bioprospecting
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional Chinese medicine theory suggests the possibility of combining the two, however, the specific mechanisms involved have not been ...
Songtao Wu, Yingying Wang, Denghui Deng, Guohua Zheng, Hanxiang Mei, Cong Wang, Xiang Zheng, Chun Gui, Fei Liao, Meixian Xiang   +9 more
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LncRNA HAS2-AS1 Promotes Glioblastoma Proliferation by Sponging miR-137

Frontiers in Oncology, 2021
GBM (Glioblastoma multiform) is the most malignant tumor type of the central nervous system and has poor diagnostic and clinical outcomes. LncRNAs (Long non-coding RNAs) have been reported to participate in multiple biological and pathological processes,
Yalin Lu, Yalin Lu, Yalin Lu, Gaochao Guo, Rujun Hong, Rujun Hong, Rujun Hong, Xingjie Chen, Xingjie Chen, Xingjie Chen, Yan Sun, Yan Sun, Yan Sun, Fang Liu, Zhimeng Zhang, Xun Jin, Xun Jin, Xun Jin, Xun Jin, Jun Dong, Kai Yu, Kai Yu, Kai Yu, Xuejun Yang, Xuejun Yang, Xuejun Yang, Yang Nan, Yang Nan, Yang Nan, Yang Nan, Qiang Huang, Qiang Huang, Qiang Huang, Qiang Huang   +33 more
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Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice

Frontiers in Immunology, 2022
HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Mingma Thsering Sherpa, Takumi Kiwamoto, Masashi Matsuyama, Yoshiya Tsunoda, Kai Yazaki, Kazufumi Yoshida, Masayuki Nakajima, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa   +10 more
doaj   +1 more source