HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration [PDF]
Journal of Ovarian Research, 2019 Background The cumulus expansion process is one of the LH mediated ovulatory processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process.
Yuval Yung +5 more
doaj +3 more sources
GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2 [PDF]
BMC Cancer, 2021 Background Endometrial cancer (UCEC) is one of the most common gynecological malignancies. We previously found that overexpression of G protein α subunit 14 (GNA14) promoted UCEC growth.
Jing Wang +5 more
doaj +4 more sources
Impact of Prunus Cerasus on PGR and HAS2 in Cumulus Cells and Fertility Outcome [PDF]
Advanced Pharmaceutical Bulletin, 2016 Purpose: Cumulus cells have a critical role in normal oocyte development and fertilization. Prunus cerasus is an anthocyanin rich berry and performs strong antioxidant activity.
Fatemeh Namvar Vansofla +3 more
doaj +4 more sources
Frontiers in Cell and Developmental Biology, 2021 ObjectiveRecent studies were widely concerned about the role of lncRNAs in hypoxic pulmonary hypertension (HPH). HAS2 was found significantly highly expressed in HPH, but the antisense of HAS2 (HAS2-AS1) has not been explored in HPH, providing a new ...
Xue Yang +4 more
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HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer
Frontiers in Pharmacology, 2022 The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Xiaodan Sun +12 more
doaj +1 more source
A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect. [PDF]
PLoS ONE, 2014 As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Targeted deletion of HAS2 gene in mice led to obvious cardiac and
Xiaomei Zhu +7 more
doaj +1 more source
Zhongguo linchuang yanjiu, 2023 Objective To analyze the diagnostic value of color Doppler ultrasound, serum hyaluronic alkane synthase 2 (HAS2)， a disintegrin and metalloproteinase domain 9 (ADAM9) and the combination in papillary thyroid microcarcinoma (PTMC). Methods Seventy-four
YU Jin, XU Xianzhao, YU Haixia, YANG Tianhuang, WU Aiqiang
doaj +1 more source
FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway
Biomolecules, 2022 Background: Fgf9 mutation was found in cleft palate patients. Our previous study indicated that Fgf9 promotes timely elevation of palate by regulating hyaluronic acid (HA) accumulation at embryonic day 13.5 (E13.5).
Yidan Sun +5 more
doaj +1 more source
Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via Protein O-GlcNAcylation [PDF]
Journal of Biological Chemistry, 2014 Changes in the microenvironment organization within vascular walls are critical events in the pathogenesis of vascular pathologies, including atherosclerosis and restenosis. Hyaluronan (HA) accumulation into artery walls supports vessel thickening and is involved in many cardiocirculatory diseases.
VIGETTI, DAVIDE +15 more
openaire +3 more sources
Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2 [PDF]
Scientific Reports, 2016 AbstractThe hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA synthesis and is the key factor in this pathway. However, the regulation of HAS2 and the HAS2-mediated pathway by microRNAs in GCs is poorly understood.
Jiying Liu +7 more
openaire +2 more sources