Results 31 to 40 of about 11,390 (192)
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion
Journal of Experimental & Clinical Cancer Research, 2016 Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang +8 more
doaj +1 more source
Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]
, 2012 Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Djafarzadeh, Roghieh +5 more
core +2 more sources
HAS2 (hyaluronan synthase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Journal of Cancer Research and Clinical Oncology, 2022 Purpose Hyaluronan modulates tumour progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis.
Jette Riecks +6 more
doaj +1 more source
Heliyon, 2023 Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1,
Xunxia Bao +9 more
doaj +1 more source
Hyaluronan: Biosynthesis and signaling [PDF]
, 2014 Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G. +5 more
core +1 more source
Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2 [PDF]
Oncogene, 2012 Epithelial-mesenchymal transition (EMT) is a developmental program, which can be adopted by cancer cells to increase their migration and ability to form metastases. Transforming growth factor β (TGFβ) is a well-studied inducer of EMT. We demonstrate that TGFβ potently stimulates hyaluronan synthesis via upregulation of hyaluronan synthase 2 (HAS2) in ...
Porsch H +5 more
openaire +3 more sources
Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance [PDF]
, 2015 The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle.
Christopher G. Faulkes +5 more
core +2 more sources
Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish [PDF]
Development, 2011 The extracellular matrix is crucial for organogenesis. It is a complex and dynamic component that regulates cell behavior by modulating the activity, bioavailability and presentation of growth factors to cell surface receptors. Here, we determined the role of the extracellular matrix protein Nephronectin (Npnt) in heart development using the zebrafish ...
Patra, Chinmoy +8 more
openaire +4 more sources
Metabolic control of hyaluronan synthases [PDF]
, 2014 Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology ...
De Luca G. +4 more
core +1 more source