Results 71 to 80 of about 11,390 (192)

ヒアルロン酸合成障害に伴う気管支喘息発症、増悪メカニズムの解明 [PDF]

, 2018
筑波大学 (University of Tsukuba ...
角田 義弥
core   +1 more source

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]

, 2017
An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A, Ghafari, F, Marei, W F A, Mohey-Elsaeed, O, Raheem, K A, Wathes, D C   +5 more
core   +3 more sources

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, EarlyView.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

High level of RNA HAS2-AS1 in the buffy coat of a patient blood sample is a more informative prognostic marker of COVID-19 clinical course compared to the level of hyaluronic acid in plasma [PDF]

The Ukrainian Biochemical Journal
Numerous studies have confirmed the association of COVID-19 clinical course with the blood levels of hyaluronic acid and long non-coding RNA HAS2-AS1 as a positive regulator of hyaluronan synthase.
E. Dubrovskyi, T. Drevytska, V. Dosenko, D. Stroy   +3 more
doaj   +1 more source

Randomised, Double‐Blinded, Placebo‐Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions

Veterinary Dermatology, EarlyView.
ABSTRACT Background Identification of offending foods in dogs with adverse food reactions is usually based on “deterioration” during open food challenges. Objectives To examine the placebo effect during double‐blinded, placebo‐controlled food challenges using a predefined set of criteria for relapse.
Evi I. Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N. Saridomichelakis   +4 more
wiley   +1 more source

A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer

Oncotarget, 2017
Cancer metastasis is the main reason for poor patient survival. Tumor cells delaminate from the primary tumor by induction of epithelial-mesenchymal transition (EMT). EMT is mediated by key transcription factors, including ZEB1, activated by tumor cell interactions with stromal cells and the extracellular matrix (ECM). ZEB1-mediated EMT and motility is
Preca, Bogdan-Tiberius, Bajdak, Karolina, Mock, Kerstin, Lehmann, Waltraut, Sundararajan, Vignesh, Bronsert, Peter, Matzge-Ogi, Alexandra, Orian-Rousseau, Véronique, Brabletz, Simone, Brabletz, Thomas, Maurer, Jochen, Stemmler, Marc   +11 more
openaire   +6 more sources

Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3* [PDF]

Journal of Biological Chemistry, 2013
Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an identical polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid. To compare the properties of these isoenzymes, COS-1 cells, with minor endogenous hyaluronan synthesis, were transfected with human Has1-3 isoenzymes.
Hyttinen Juha, Rilla Kirsi, Tammi Markku, Tammi Raija, Kärnä Riikka, Oikari Sanna, Jokela Tiina   +6 more
openaire   +2 more sources

Major adverse cardiovascular events following partial nephrectomy: a procedure-specific risk index

Therapeutic Advances in Urology, 2022
Introduction: Partial nephrectomy (PN) is associated with a non-negligible risk of postoperative cardiovascular morbidity and mortality. Identification of high-risk patients may enable optimization of perioperative management and consideration of ...
Ali A. Nasrallah, Habib A. Dakik, Nassib F. Abou Heidar, Jad A. Najdi, Oussama G. Nasrallah, Mazen Mansour, Hani Tamim, Albert El Hajj   +7 more
doaj   +1 more source

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis [PDF]

, 2017
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms
Anemone, Lucia, Bongiorno-Borbone, Lucilla, Compagnone, Mirco, Fierro, Claudia, Gatti, Veronica, Markert, Elke Katrin, Mauriello, Alessandro, Melino, Gerry, Peschiaroli, Angelo, Presutti, Dario, Ruberti, Giovina, Vousden, Karen H, Zhou, Huiqing   +12 more
core   +2 more sources

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source