Results 131 to 140 of about 1,470,445 (304)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
par les ordres De M. De Ferriol et gravees en 1712 et 1713 par les soins de M. Le Hay [PDF]
Sultan nezdinde büyükelçi bay D. Ferriol'un emirleri üzerine 1707 ve 1708 tarihlerinde orjinal olarak yapılan tablolardan sayın le Haye tarafından 1712-1713 tarihlerinde kopya edilen çeşitli Şark milletlerini temsil eden 100 adet basma resim külliyatı ...
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
(H. M. Rogers) Hortensia to Mrs. Eliza Kortright Monroe Hay., 17 May 1831 [PDF]
Hope grandfather continues to gain strength. He is head of our family, the cornerstone of our building. Educated her. Upset that James Monroe (probably nephew) is coolly calculating on his death. Has gotten Life of Byron.
Rogers, Hortensia Monroe
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Interview with Graeme Turner, November 2012. Interview conducted by James Hay. Interview edited by James Hay [PDF]
, 2013 Hay, James, Turner, Graeme
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Genet Jeanne Louise Henriette Campan to Mrs. Eliza Kortright Monroe Hay., 30 October 1821 [PDF]
I am exceedingly anxious about everything concerning you and your respected parents. The loss of my dear husband. A painful gland in my breast gives me just fears, concerning the duration of my existence.
Campan, Mme (Jeanne-Louise-Henriette), 1752-1822
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source