Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Lyophilized rumen fluid from goats fed different roughage-based diets: fermentation characteristics, microbial communities, and post-reconstitution <i>in vitro</i> fermentation performance. [PDF]
Na M +6 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Effects of replacing natural pasture hay with Napier grass on lactation performance and estimated methane emissions in dairy cows. [PDF]
Mekcha E +4 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
(H. M. Rogers) Hortensia to Mrs. Eliza Kortright Monroe Hay., 17 May 1831
Hope grandfather continues to gain strength. He is head of our family, the cornerstone of our building. Educated her. Upset that James Monroe (probably nephew) is coolly calculating on his death. Has gotten Life of Byron.
Rogers, Hortensia Monroe
core
Research on selection of hybrid combination of alfalfa male sterile line for high yield
The experiment aimed to screen for high-yielding hybrid combinations of male-sterile alfalfa lines. A total of 10 hybrid combinations were prepared with one alfalfa male sterile line (MS-GN) as the female parent and 10 excellent alfalfa plants (Alfalfa ...
ZENG Yan-xia +7 more
doaj
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source

