Expression of HBsAg and HBsAg in liver tissue, correlation with disease activity
The pattems of Hepatitis B surface antigen (HBsAg) and Hepatitis B core antigen (HBcAg) expression were studied in liver biopsies taken from 41 patients with chronic HBV disease. Immunohistochemical methods were used on deparaffinized sections for the identification of HBsAg and HBcAg in liver tissue. lkenty-one of the 41 cases (5 1.2%) were classified
Nakopoulou, Lydia +4 more
openaire +1 more source
HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi +8 more
wiley +1 more source
Association of week-12 HBsAg Decline with HBsAg Clearance in Patients with Hepatitis B-Related Cirrhosis Receiving Pegylated Interferon Combined with Nucleos(T)ide Analogue Therapy: A Retrospective Cohort Study. [PDF]
Yang WY, Lin Y, Lin C, Pan C, Ye YM.
europepmc +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Predictive value of serum HBcrAg in antiviral therapy for chronic hepatitis B. [PDF]
Wang S +12 more
europepmc +1 more source
This study investigates the impact of switching to long‐acting (LA) injectable cabotegravir and rilpivirine (CAB/RPV‐LA) on immune‐activation and ‐senescence in people with HIV (PWH). Thirty‐seven PWH switching to CAB/RPV‐LA and nine continuing oral ART were analysed over 72 weeks. LA therapy led to significant reductions in activation T and senescence
Mariasilvia Guardiani +16 more
wiley +1 more source
Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis. [PDF]
He M +10 more
europepmc +1 more source
ABSTRACT Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer‐related deaths in Malaysia. Early detection increases the likelihood of curative treatment and improves survival. This consensus document aims to provide evidence‐based, locally relevant recommendations for the prevention and early detection of HCC.
Su Yin Lau +18 more
wiley +1 more source
Long-Term Clinical Outcomes of Kidney Transplantation from Hepatitis B Surface Antigen (HBsAg)-Positive Donors to HBsAg-Negative Recipients: A Systematic Review and Meta-Analysis of Real-World Studies. [PDF]
Liang C, Luo Y, Yin S, Song T, Lin T.
europepmc +1 more source
ABSTRACT As little is known about the disease burden of chronic hepatitis D virus (HDV) infection, this study examined health‐related quality of life (HRQoL) and fatigue at different disease stages. This was a real‐world quantitative cross‐sectional survey of patients in Germany, Italy, Spain and the USA.
P. Lampertico +11 more
wiley +1 more source

