Results 111 to 120 of about 73,125 (286)

Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening [PDF]

, 2015
Background: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei.
Bernard A. M. Fang, FengDi Li, GangDe Zhao, HaiQing Wu, Hui Wang, KeHui Liu, LanYi Lin, Qing Xie, Shisan Bao, WeiLiang Tang, XiaoGang Xiang   +10 more
core   +3 more sources

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Occult Hepatitis B Infection in Patients With Cryptogenic Liver Cirrhosis in Southwest of Iran [PDF]

, 2015
Background: Chronic hepatitis B virus (HBV) infection has a broad spectrum of manifestation, ranging from silent carrier state to advanced cirrhosis and hepatocellular carcinoma.
Ackerman Z, Agarwal N, Alavian SM, Berasain C, Blackberg J, Carman WF, Chemin I, He J, Honarkar Z, Kaviani MJ, Lavanchy D, Loriot MA, Merat S, Ramezani A, Torbenson M   +14 more
core   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Artificial neural network accurately predicts hepatitis B surface antigen seroclearance [PDF]

, 2014
BACKGROUND & AIMS: Hepatitis B surface antigen (HBsAg) seroclearance and seroconversion are regarded as favorable outcomes of chronic hepatitis B (CHB).
Fong, DYT, Fung, JYY, Hung, IFN, Lai, CL, Seto, WKW, Shi, KQ, Tong, T, Wong, DKH, Yuen, JCH, Yuen, RMF, Zheng, MH   +10 more
core   +1 more source

Very Early‐Stage Detection Is Associated With Improved Survival in Patients With Unifocal Hepatocellular Carcinoma

Alimentary Pharmacology &Therapeutics, EarlyView.
In a multicentre cohort of patients with unifocal HCC, patients with very early stage disease had a survival advantage over patients diagnosed at an early stage. Factors associated with mortality included worse liver function, larger tumour size and higher AFP levels.
Thomas Hunold, Karim Seif El Dahan, Suraj Pai, Amit G. Singal, Neehar D. Parikh   +4 more
wiley   +1 more source

The hepatitis B virus reactivation after transarterial chemoembolization in Chinese hepatocellular carcinoma patients with low serum hepatitis B virus DNA level

Therapeutics and Clinical Risk Management, 2015
Wenbo Shao, Fengjuan Zhang, Ning Cong, Jinpeng Li, Jinlong SongDepartment of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People’s Republic of ChinaObjective ...
Shao W, Zhang F, Cong N, Li J, Song J
doaj  

Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease‐Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute‐on‐Chronic Liver Failure and Death

Alimentary Pharmacology &Therapeutics, EarlyView.
Indocyanine green clearance by pulse dye densitometry correlates with portal hypertension, systemic inflammation and circulatory dysfunction in advanced chronic liver disease. While diagnostic accuracy for CSPH was limited, ICG‐R15 independently predicted decompensation and ACLF/liver‐related mortality, highlighting its prognostic value across disease ...
Mathias Jachs, Tânia Carvalho, Benedikt Simbrunner, Georg Semmler, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Paul Thöne, Nina Dominik, Georg Kramer, Christian Sebesta, Michael Schwarz, David Bauer, Albert F. Stättermayer, Matthias Pinter, Michael Trauner, Thomas Reiberger, Mattias Mandorfer   +17 more
wiley   +1 more source

HBV RNA at 6 months after nucleos(t)ide analogues treatment can predict antiviral efficacy in chronic hepatitis B patients

BMC Gastroenterology
Background This multicenter study evaluated serum HBV RNA as a prognostic biomarker for nucleos(t)ide analogue (NA) therapy in chronic hepatitis B (CHB), focusing on correlations with HBV DNA/HBsAg and predictive value for virological response (VR) and ...
Yandi Xie, Xiaojing Zhang, Xiaozhou Yang, Sujun Zheng, Shuyun Zhang, Xiaoying Zhang, Haiyan Kang, Xuefei Duan, Wenpin Cai, Peng Yin, Xinghuan Ma, Juan liu, Fengmin Lu, Lizhong Dai, Bo Feng   +14 more
doaj   +1 more source

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source