Results 91 to 100 of about 1,553,868 (271)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver [PDF]

, 2005
The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period.
J A Ross, Wheelhouse, Nicholas M, D J Harrison, Wigmore, S J, Lai, P B S, P B S Lai, Wheelhouse, N M, Ross, J A, Harrison, D J, N M Wheelhouse, S J Wigmore   +10 more
core   +1 more source

Occult HBV infection among Egyptian hepatocellular carcinoma patients

Virology Journal, 2011
Background Occult HBV infection accelerates the progression of liver fibrosis, cirrhosis, and finally leading to hepatocellular carcinoma (HCC). This study analyzed the occult HBV-genotypes in HCC patients. Methods To achieve our objective, matched serum
Mansor Tarek M, Hafez Mohamed M, Hassan Zeinab K, Zekri Abdel   +3 more
doaj   +1 more source

Association of IFN‐γ +874 T/A Polymorphism With COVID‐19 Susceptibility, Severity, and Inflammatory Response: A Case–Control Study From Southern Iran

Journal of Clinical Laboratory Analysis, EarlyView.
Graphical abstract illustrating the association between IFN‐γ +874 T/A polymorphism and COVID‐19 outcomes. TA and AA genotypes are linked to increased susceptibility, higher inflammatory markers (notably IL‐6), greater disease severity, and longer hospitalization.
Nasir Arefinia, Bahman Aghcheli, Seyed Mohammad Ali Hashemi, Zohreh‐al‐sadat Ghoreshi, Emad Behboudi   +4 more
wiley   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Aflatoxin contamination in dried fruits and nuts in Bangladesh: Occurrence, dietary exposure, and health risk assessment

JSFA reports, EarlyView.
Abstract Background Dried fruits and nuts are widely consumed for their desirable sensory qualities and high nutritional value, providing essential nutrients such as proteins, healthy fatty acids, potassium, dietary fiber, and bioactive compounds. However, they are highly susceptible to aflatoxin contamination, particularly in humid tropical regions ...
Tasniya Akter, Mohammad Tariqul Hassan, Abira Nowar, Farhana Rinky, Sharmin Rumi Alim   +4 more
wiley   +1 more source

产妇血清HBV DNA含量对乳汁和新生儿血清HBV DNA浓度的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2010
【目的】 探讨乙型肝炎病毒携带产妇血清HBV DNA含量对乳汁和新生儿血清中HBV DNA含量的影响,以指导孕期处理和母乳喂养。【方法】 选择乙型肝炎病毒携带产妇145例,采用荧光定量聚合酶链反应(FQ-PCR)技术对产妇血清，母乳和新生儿血清HBV DNA进行检测,并将产妇血清HBV DNA浓度分3级,分析产妇血清不同HBV DNA浓度级对乳汁及新生儿血清HBV DNA浓度的影响。【结果】 血清HBV DNA < 500 copies/mL的产妇74例,乳汁中检出HBV DNA阳性为零 ...
doaj  

Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication

, 2008
Recent studies have demonstrated that the effect of inhibition of HBV replication can be achieved by RNA interference (RNAi) at both the cellular and organismal levels. However, HBV replication cannot be completely inhibited by this method. To completely
Tang, Kai-Fu, Ren, Hong, Huang, Ai-Long, Zhou, Xi-Yuan, Liu, Qi, Wang, Yan, Zeng, Weiqun, Xie, Jing, K. F. Tang, H. Ren, Zuo, Guo-qing, Chen, Min, Xiang, Rong   +12 more
core   +1 more source

HBV DNA quantification.

, 2013
Serum HBV DNA levels were quantified in 72 consecutive samples with the Abbott Real Time HBV PCR (threshold at 1.7 log IU/mL). HBV target was not detected in 21 patients; viral load was detected in 51 patients, 16 of whom had a viral load greater than 7 ...
Pierre Abgueguen (483490), Amélie Rameau (483496), Alexandra Ducancelle (483489), Jacques Birguel (483491), Jean-Jacques Sobnangou (483495), Françoise Lunel-Fabiani (483498), Hélène Le Guillou-Guillemette (483494), Jean-Marie Huraux (483497), Wael Mansour (483492), Adeline Pivert (483493)   +9 more
core   +1 more source