HBV-Integration Studies in the Clinic: Role in the Natural History of Infection
Viruses, 2021 Hepatitis B virus (HBV) infection is a major global health problem causing acute and chronic liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV covalently closed circular DNA (cccDNA) is essential for viral replication
Teresa Pollicino, Giuseppe Caminiti
doaj +1 more source
Clinical, epidemiological and virological features of acute hepatitis B in Italy [PDF]
, 2015 Purpose To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy.
Alessandro Remo Zanetti +10 more
core +1 more source
Characterization of the hepatitis B virus DNA detected in urine of chronic hepatitis B patients
BMC Gastroenterology, 2018 Background Detection of human hepatitis B virus (HBV) DNA in the urine of patients with chronic hepatitis B infection (CHB) has been reported previously, suggesting urine could provide a potential route of horizontal HBV transmission.
Surbhi Jain +10 more
doaj +1 more source
Liver transplantation for viral hepatitis in 2015 [PDF]
, 2016 Liver transplantation (LT) is a life-saving treatment for patients with end-stage liver disease and for patients with liver cell cancer related to liver disease.
Bortoluzzi, Ilaria +8 more
core +1 more source
Baseline HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine. [PDF]
, 2007 Aim: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT).
Chae, Hee Bok, Hann, Hie-Won
core +2 more sources
Revised cutoff values of ALT and HBV DNA level can better differentiate HBeAg (-) chronic inactive HBV patients from active carriers [PDF]
, 2011 ELISA is still used as primary test for diagnosis HBV disease. However, ELISA-positive patients were marked as HBV inactive after confirmation with PCR and vice versa.
Bushra BushraIjaz +5 more
core +1 more source
Maternal transmission risk and antibody levels against hepatitis B virus e antigen in pregnant women
International Journal of Infectious Diseases, 2014 Background: The generation of antibodies (anti-HBe) against hepatitis B virus (HBV) e antigen (HBeAg) often coincides with clinical remission in chronic HBV patients. We aimed to examine the effect of maternal anti-HBe in protection against HBV mother-to-
Ling-Ling Lu +10 more
doaj +1 more source
Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients [PDF]
, 2007 AIM: To evaluate the effect of antiviral agents on intrahepatic HBV DNA in HBeAg-positive chronic hepatitis B patients. METHODS: Seventy-one patients received treatment with lamivudine, interferon alpha (IFN-alpha 2b) or sequential therapy with ...
Chen, Xin-Yue +10 more
core +1 more source
Annals of Hepatology, 2011 Background and Aims. The risk of recurrent hepatitis B virus (HBV) infection and prognosis of liver transplantation in patients with HBV has dramatically changed with the use of prophylaxis including hepatitis B immune globulin (HBIg) and antiviral ...
Isabel Campos-Varela +9 more
doaj +1 more source
The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation
Viruses, 2020 The tripartite motif (TRIM) protein family is an E3 ubiquitin ligase family. Recent reports have indicated that some TRIM proteins have antiviral functions, especially against retroviruses.
Ting Mu +4 more
doaj +1 more source